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Cancer immunotherapy can use small numbers of ‘stem-like’ immune cells to destroy large tumors in mice

A new approach to stimulating immune cells enhances their anticancer activity, resulting in a powerful anti-tumor response in mice, according to a study by researchers at the National Cancer Institute, a part of the National Institutes of Health. This work represents an important advance in the development of immunotherapy for cancer and appears online June 14, 2009 in Nature Medicine.

15 Jun 2009

A new way to tackle age-related macular degeneration

Researchers at the University of North Carolina at Chapel Hill School of Medicine in collaboration with lead investigators at the University of Kentucky have identified a new target for the diagnosis and treatment of age-related macular degeneration, the most common cause of blindness in older Americans.

15 Jun 2009

Scientists launch Gene Expression Atlas

Today, researchers at the European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI) launch a new database, the Gene Expression Atlas, which allows scientists to search and compare gene expression data at unprecedented detail and scope. Observing how gene expression varies in different cell types, tissues and under disease conditions can help researchers understand gene function and to develop new drugs and therapies.

15 Jun 2009

India to promote drugs in Africa after fake Chinese drugs 'made in India' seized

India launched a project to promote its $10.7 billion pharmaceutical industry in Africa after fake drugs labeled "Made in India," but with actual origins in China were seized on the continent, IANS/Hindu reports.

13 Jun 2009

Study shows promise for new cancer-stopping therapy

Researchers at Nationwide Children's Hospital and Johns Hopkins University have discovered that delivering a small molecule that is highly expressed in normal tissues but lost in diseased cells can result in tumor suppression.

12 Jun 2009

The Lancet to launch series on the state of public health in Southeast Asia

As the global health community confronts the threat of a major new influenza pandemic, The Lancet, in partnership with the Rockefeller Foundation and the China Medical Board, will develop a major Series to assess the state of public health in southeast Asia.

12 Jun 2009

Bioprocess increases vaccine yield

Empa researchers have managed to adapt a process for manufacturing certain vaccines - in particular that against Haemophilus influenzæ bacteria - for use in bioreactors, with the result that the yield is enhanced enormously.

12 Jun 2009

Researchers discover how prion protein damages brain cells

Scientists at the National Institutes of Health have gained a major insight into how the rogue protein responsible for mad cow disease and related neurological illnesses destroys healthy brain tissue.

11 Jun 2009

The 'hijacking mechanism' of HIV-1 pinpointed

Researchers at McGill University and the affiliated Lady Davis Institute for Medical Research at Montreal's Jewish General Hospital - along with colleagues at the University of Manitoba and the University of British Columbia - may have found a chink in the armour of the human immunodeficiency virus type 1 (HIV-1), the microorganism which causes AIDS. They have pinpointed the key cellular machinery co-opted by HIV-1 to hijack the human cell for its own benefit.

10 Jun 2009

Innovative partnership targets cancer-causing 'chaperones'

Cancer Research Technology (CRT) and The Institute of Cancer Research (ICR) today announced a major research collaboration with AstraZeneca. The three partners will combine their expertise to discover and develop potential new anti-cancer drugs to target molecular "chaperones" which support the growth of cancer cells.

10 Jun 2009

Gene variation associated with resistance to chemotherapy drug in women with breast cancer

Researchers have found links between an individual's genetics and their response to treatment with chemotherapy. The findings, by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and colleagues, show how a genetic variant, located in the SOD2 gene, may affect how a person responds to the chemotherapy drug cyclophosphamide. Cyclophosphamide is used in the treatment of breast and other cancers.

9 Jun 2009

Dioxins in food chain linked to breastfeeding problems

Exposure to dioxins during pregnancy harms the cells in rapidly-changing breast tissue, which may explain why some women have trouble breastfeeding or don’t produce enough milk, according to a University of Rochester Medical Center study.

9 Jun 2009

Researchers find early signs of diabetes in healthy children as young as seven

Research conducted under the direction of Melinda Sothern, PhD, Professor and Director of Health Promotion at the LSU Health Sciences Center New Orleans School of Public Health, showing early signs of diabetes in healthy children as young as seven years old will be presented at the American Diabetes Association 2009 Annual Scientific Session Meeting in New Orleans.

9 Jun 2009

Insomnia and sleep duration linked to diabetes

Individuals with insomnia and objective short sleep duration are at increased risk for developing diabetes, according to a research abstract that will be presented on Tuesday, June 9, at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies.

9 Jun 2009

Sleep deprivation a factor in weight gain

The new research by scientists at the University of South Australia has revealed that though their appetites had decreased the study participants gained weight when their sleep was restricted.

8 Jun 2009

Research identifies 3D structure of key nuclear pore building block

The genome of complex organisms is stashed away inside each cell's nucleus, a little like a sovereign shielded from the threatening world outside.

8 Jun 2009

Discovery 'significant step' in understanding leukaemia drug resistance

Scientists have pinpointed an enzyme responsible for breaking down and inactivating a key childhood leukaemia drug, which could help to explain why around 20 per cent of patients do not respond to therapy. Their findings are published in the Journal of Clinical Investigation.

8 Jun 2009

WHO recommends global use of rotavirus vaccines - can protect millions of children from diarrhoeal diseaseas

The World Health Organization (WHO) has recommended that rotavirus vaccination be included in all national immunization programmes to provide protection against a virus that is responsible for more than 500,000 diarrhoeal deaths and 2 million hospitalizations every year among children. More than 85% of these deaths occur in developing countries in Africa and Asia. This new policy will help ensure access to rotavirus vaccines in the world's poorest countries.

5 Jun 2009

Cancer vaccine efficacy enhanced using anti-diabetic drug Metformin

After a vaccination or an infection, the human immune system remembers to keep protecting against invaders it has already encountered, with the aid of specialized B-cells and T-cells. Immunological memory has long been the subject of intense study, but the underlying cellular mechanisms regulating the generation and persistence of long-lived memory T cells remain largely undefined. Now, University of Pennsylvania School of Medicine researchers have found that a common anti-diabetic drug might enhance the effectiveness of vaccines. The findings are described this week in an advanced online publication of Nature.

4 Jun 2009

Discovery of new genetic immune disorder in children

Your immune system plays an important function in your health - it protects you against viruses, bacteria, and other toxins that can cause disease. In autoinflammatory diseases, however, the immune system goes awry, causing unprovoked and dangerous inflammation.

4 Jun 2009