Genetic Engineering News and Research

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OMT announces new human antibody platform using genetically engineered rats expressing human antibodies

Open Monoclonal Technology, Inc. (OMT) today announced its new human antibody platform using the first genetically engineered rats expressing a human antibody repertoire. The company, which also created the first targeted knockout rats in 2009, is now cross-breeding the knockout animals with the rats expressing human antibodies to finalize its platform.

9 Dec 2010

Expert panel explores how to engage pediatricians, primary care physicians in preventing childhood obesity

As the prevalence of childhood obesity approaches epidemic levels, physicians on the "front line" need to become more involved in obesity prevention and weight management to reverse this dangerous trend among their young patients. But several obstacles discourage pediatricians and other primary care physicians from taking a more active role in managing childhood obesity.

9 Dec 2010

Studies shows that social stress accelerates atherosclerosis development

Studies on genetically engineered mice show that social stress activates the immune system and accelerates the development of atherosclerosis. Commonly used drugs to reduce blood pressure, however, may stop this process. This is the conclusion of a thesis presented at the University of Gothenburg, Sweden.

7 Dec 2010

Seasonal light cycles can affect development of babies' specific brain function: Study

The season in which babies are born can have a dramatic and persistent effect on how their biological clocks function.

6 Dec 2010

Healthy People 2020 targets barriers to breastfeeding

For the first time, the barriers to breastfeeding are being addressed at the highest level of government. With the release today of Healthy People 2020, the U.S. Department of Health and Human Services has targeted the new 10-year goals for our nation's health - and supporting breastfeeding is prominent among them.

4 Dec 2010

Chaperone protein study could lead to effective therapies for Alzheimer's, neurological disorders

Dynamic regulation of the chaperone protein Hsp27 was required to get rid of abnormally accumulating tau in the brains of mice genetically modified to develop the memory-choking tau tangles associated with Alzheimer's disease, a University of South Florida-led study found.

4 Dec 2010

New clues into mechanisms underlying antiphospholipid syndrome

Thanks to findings by UT Southwestern Medical Center researchers, individuals with a potentially life-threatening condition predisposing them to blood clots, or thrombosis, might someday receive therapy to prevent the condition.

4 Dec 2010

Exposure to polluted air leads to accumulation of abdominal fat and insulin resistance

Exposure to polluted air early in life led to an accumulation of abdominal fat and insulin resistance in mice even if they ate a normal diet, according to new research.

3 Dec 2010

Dysfunction in blood vessels plays a role in Alzheimer's disease development

A dysfunction in the lining of blood vessels that is linked to cardiovascular illness also appears to play a role in the development of Alzheimer's disease, according to a study published in Circulation Research: Journal of the American Heart Association.

3 Dec 2010

Lipids react and change to bacterial stimulus, trigger cell's immune response

For the first time, scientists have described not only the identities and quantities of fat species in a living mammalian cell in this case, a mouse macrophage or white blood cell but they also report how these lipids react and change over time to a bacterial stimulus triggering the cell's immune response.

2 Dec 2010

Medical, socioeconomic, and gender-based factors impact global women's health issues

Access to quality reproductive healthcare for women around the globe is a fundamental aspect of a woman's human rights, freedom, equity, and right to control her own body. A Special Section on Global Women's Reproductive Health in the current issue of Journal of Women's Health, a peer-reviewed publication published by Mary Ann Liebert, Inc., explores the compelling medical, socioeconomic, and gender-based factors that impact global women's health issues. The Special Focus articles are available free online.

1 Dec 2010

PhaseBio initiates Glymera Phase 1/2a clinical trial in patients with Type 2 diabetes

PhaseBio Pharmaceuticals, Inc., a privately held, clinical-stage biotechnology company developing drugs to treat diabetes, metabolic disease and cardiovascular disease, announced today that it has begun Phase 1/2a clinical testing with its lead compound, Glymera(PB1023), in patients with Type 2 diabetes.

1 Dec 2010

New strategy to prevent memory deficits in mouse model with AD

Scientists at the Gladstone Institute of Neurological Disease (GIND) in San Francisco have discovered a new strategy to prevent memory deficits in a mouse model of Alzheimer's disease (AD).

28 Nov 2010

Researchers discover cells’ response to sour tastes

This Thanksgiving, when you bite into the cranberry sauce and the tartness smacks your tongue as hard as that snide comment from your sister, consider the power of sour. Neurobiology researchers at the University of Southern California have made a surprising discovery about how some cells respond to sour tastes.

25 Nov 2010

Childhood obesity linked to adult metabolic abnormalities and cardiovascular disease

Mounting evidence linking childhood obesity to an increasing risk of obesity, heart disease, type 2 diabetes, and other cardiovascular and metabolic disorders in adulthood is clearly presented in a comprehensive review article in the current issue of Childhood Obesity, published by Mary Ann Liebert, Inc. The article is available free online.

19 Nov 2010

AVEO announces results from tivozanib Phase 1b clinical trial for advanced gastrointestinal cancers

AVEO Pharmaceuticals, Inc., a biopharmaceutical company focused on discovering, developing and commercializing cancer therapeutics, today announced results from a Phase 1b clinical trial evaluating the company's lead product candidate, tivozanib, a highly potent and selective inhibitor of VEGF receptors 1, 2, and 3, in combination with FOLFOX6, a standard chemotherapy regimen, in patients with advanced gastrointestinal (GI) cancers.

19 Nov 2010

Study finds sfrp2 protein may play a role in accelerating heart muscle repair

Heart tissue and stem cells spring into action to begin repairing muscle damaged in a heart attack, and researchers at Duke University School of Medicine found that a protein naturally produced in the body may potentially play a role in accelerating heart muscle repair.

18 Nov 2010

Researchers reveal mechanism of early-stage anthrax infection

Researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have determined a key mechanism by which Bacillus anthracis bacteria initiate anthrax infection despite being greatly outnumbered by immune system scavenger cells. The finding, made by studying genetically modified mice, adds new detail to the picture of early-stage anthrax infection and supports efforts to develop vaccines and drugs that would block this part of the cycle.

18 Nov 2010

Stratatech receives SBIR grant to develop anti-infective living human skin substitute

Stratatech Corp., a privately-held regenerative medicine company, today announced that it has been awarded a $3.5 million Fast-Track SBIR grant to expand the development of its anti-infective living human skin substitute.

17 Nov 2010

New mathematical method predicts dominant strain of influenza virus

Rice University scientists have found a way to predict rapidly whether a new strain of the influenza virus should be included in the annual seasonal flu vaccine. While it sometimes takes new flu strains up to three years to become dominant worldwide, the new method can predict whether they will become dominant as little as two weeks after the sequence first appears in the GenBank database, the National Institutes of Health's collection of all publicly available DNA sequences.

16 Nov 2010

Genetic Engineering News and Research

OMT announces new human antibody platform using genetically engineered rats expressing human antibodies

Expert panel explores how to engage pediatricians, primary care physicians in preventing childhood obesity

Studies shows that social stress accelerates atherosclerosis development

Seasonal light cycles can affect development of babies' specific brain function: Study

Healthy People 2020 targets barriers to breastfeeding

Chaperone protein study could lead to effective therapies for Alzheimer's, neurological disorders

New clues into mechanisms underlying antiphospholipid syndrome

Exposure to polluted air leads to accumulation of abdominal fat and insulin resistance

Dysfunction in blood vessels plays a role in Alzheimer's disease development

Lipids react and change to bacterial stimulus, trigger cell's immune response

Medical, socioeconomic, and gender-based factors impact global women's health issues

PhaseBio initiates Glymera Phase 1/2a clinical trial in patients with Type 2 diabetes

New strategy to prevent memory deficits in mouse model with AD

Researchers discover cells’ response to sour tastes

Childhood obesity linked to adult metabolic abnormalities and cardiovascular disease

AVEO announces results from tivozanib Phase 1b clinical trial for advanced gastrointestinal cancers

Study finds sfrp2 protein may play a role in accelerating heart muscle repair

Researchers reveal mechanism of early-stage anthrax infection

Stratatech receives SBIR grant to develop anti-infective living human skin substitute

New mathematical method predicts dominant strain of influenza virus

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