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New discovery on how rheumatoid arthritis destroys bone

Researchers have discovered key details of how rheumatoid arthritis (RA) destroys bone, according to a study published in the Aug. 22 edition of the Journal of Biological Chemistry. The findings are already guiding attempts to design new drugs to reverse RA-related bone loss and may also address more common forms of osteoporosis with a few adjustments.

20 Aug 2008

Addiction drug Vigabatrin proves successful in animal weight loss study

Vigabatrin, a medication proposed as a potential treatment for drug addiction by scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory, also leads to rapid weight loss and reduced food intake according to a new animal study from the same research group.

20 Aug 2008

Newly uncovered cells may be critical in psoriasis

Psoriasis, one of humanity's oldest known diseases, has also been one of its most misunderstood. But in a new study that could change researchers' perspective of the skin disorder and potentially lead to powerful new drug targets, Rockefeller University scientists have found that the source of psoriasis may be a single population of inflammatory cells that act as instigators by priming the body's immune system for self-attack.

20 Aug 2008

Scientists discover how mutation in the copper-regulating protein ATP7B causes Wilson disease

Using a combination of computer simulations and cutting-edge lab experiments, physical biochemists at Rice University have discovered how a small genetic mutation -- which is known to cause Wilson disease -- subtly changes the structure of a large, complex protein that the body uses to keep copper from building up to toxic levels.

19 Aug 2008

Rifamycin antibiotics attack tuberculosis bacteria with walls, not signals

Amid concerns about the rising number of new tuberculosis cases worldwide, researchers led by Rockefeller University's Seth A. Darst have reexamined and disproved a theory that describes how a potent class of antibiotics kills a deadly form of bacteria. The findings, which will appear in this week's online issue of the Proceedings of the National Academy of Sciences, not only bring scientists closer to understanding how these antibiotics work but also how the bacteria become resistant to their effects.

19 Aug 2008

New discovery may lead to new drugs to regulate sleep

A team of scientists from Oxford University in the UK have discovered the reason why people feel drowsier in dim lighting and more alert in bright white light.

19 Aug 2008

Teens with poor sleep habits may have higher blood pressure

In new research, the sleeping habits of teenagers has come under scrutiny and has found that not getting enough sleep may be linked to a rise in their blood pressure.

18 Aug 2008

Antibodies to 1918 flu pandemic may provide means to tackle bird flu threat

Scientists in the United States have discovered that elderly survivors of the original 1918 flu pandemic, still have immunity to the virus.

18 Aug 2008

Moisturisers may increase the risk of skin cancer

In news that will make many women wonder and no doubt make some panic, scientists are now warning that the moisturisers used by millions every day may be increasing their risk of developing skin cancers.

18 Aug 2008

Dual-mode nanoparticles image tumors using MRI and PET

Medical imaging represents one of the most used and useful procedures in the oncologist's diagnostic toolkit, even though each of the most useful techniques-magnetic resonance imaging (MRI), computerized tomography x-ray imaging (CT), and positron emission tomography (PET) scanning-has its own set of limitations.

17 Aug 2008

By amplifying cell death signals, scientists make precancerous cells self-destruct

When a cell begins to multiply in a dangerously abnormal way, a series of death signals trigger it to self-destruct before it turns cancerous. Now, in research to appear in the August 15 issue of Genes & Development, Rockefeller University scientists have figured out a way in mice to amplify the signals that tell these precancerous cells to die. The trick: Inactivating a protein that normally helps cells to avoid self-destruction.

17 Aug 2008

Psychological stress and how it might affect allergy sufferers

A new study here shows that even slight stress and anxiety can substantially worsen a person's allergic reaction to some routine allergens.

14 Aug 2008

Universal gene signaling mechanism identified by UB molecular researchers

A novel gene signaling mechanism that controls whether a stem cell develops into its destined tissue or fails to differentiate and becomes cancer has been identified by researchers in the multi-laboratory Molecular and Structural Neurobiology and Gene Therapy Program based at the University at Buffalo.

14 Aug 2008

Portable test for bird flu promises to save many lives

An easily portable device which tests for bird flu in humans promises to save lives by cutting the time it takes to spot potentially lethal cases down to a few hours.

14 Aug 2008

Researchers show how DNA repairs may reshape the genome

Researchers at Duke University Medical Center and at the National Institute of Environmental Health Sciences (NIEHS) have shown how broken sections of chromosomes can recombine to change genomes and spawn new species.

13 Aug 2008

18 cases of extensively drug-resistant tuberculosis found in California

In the first statewide study of extensively drug-resistant tuberculosis (XDR TB) in the United States, California officials have identified 18 cases of the dangerous and difficult-to-treat disease between 1993 and 2006, and 77 cases that were one step away from XDR TB. The study appears in the August 15 issue of Clinical Infectious Diseases, now available online.

13 Aug 2008

Democrats opposing Supreme Court decision in favor of pre-emption pandering to tort lawyers, editorial says

The U.S. Supreme Court's "sensible" 8-1 ruling in the case of Reigel v. Medtronic, stating that medical devices approved by FDA are exempt from product liability lawsuits in state courts, "makes sense for many reasons" but has "nonetheless sent up yowls" from Democratic members of Congress who have proposed the Medical Device Safety Act (S 3398, HR 6381) to overturn the ruling, a Wall Street Journal editorial states.

13 Aug 2008

A snooze button for the circadian clock

We may use the snooze button to fine-tune our sleep cycles, but our cells have a far more meticulous and refined system. Humans, and most other organisms, have 24-hour rhythms that are regulated by a precise molecular clock that ticks inside every cell.

13 Aug 2008

Venezuelan Indians dying from rabies spread by bats

Scientists from the United States say early investigations into the deaths of a number of tribal Indians in northeastern Venezuela suggest that they may have been infected by a type of rabies carried by bats.

13 Aug 2008

Rare case explains why some infected with HIV remain symptom free without antiretroviral drugs

AIDS experts at Johns Hopkins say they have compelling evidence that some people with HIV who for years and even decades show extremely low levels of the virus in their blood never progress to full-blown AIDS and remain symptom free even without treatment, probably do so because of the strength of their immune systems, not any defects in the strain of HIV that infected them in the first place.

12 Aug 2008