Immune Response News and Research

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Study finds rhinovirus reduces SARS-CoV-2 replication in airway epithelial cells

A recent study has demonstrated that SARS-CoV-2 infection induces a significantly lower interferon response than rhinovirus infection.

24 Nov 2021

Bat coronavirus ecology, evolution, and spillover

In a review published in Nature Reviews Microbiology, the authors collate information about the ecology and evolution of bat coronaviruses.

24 Nov 2021

Vaping linked to dysregulation of mitochondrial genes and immune response genes

Since they hit the market, e-cigarettes have been touted as a safe alternative to tobacco cigarettes for adult smokers.

24 Nov 2021

Limited immune responses three months after Pfizer-BioNTech vaccination among elderly

In this study, published on the medRxiv* preprint server, the humoral response to SARS-CoV-2 was assessed before and after three months of administration of the BNT162b2 mRNA COVID-19 vaccination (Pfizer-BioNTech). In addition, elders' humoral responses were compared to those of a younger group, and a functional neutralization experiment against the Wuhan-Hu-1 (WH1) virus and the Delta variant was carried out.

23 Nov 2021

Vaccine-induced immune responses for SARS-CoV-2 in patients receiving anti-CD20 B-cell depleting therapies

A new study published on the medRxiv* preprint server analyzed the trajectories of anti-SARS-CoV-2 antibodies in patients from the RituxiVac study were compared to healthy volunteers. In addition, they investigated the immunogenicity of a third vaccine dose in previously non-responding patients.

23 Nov 2021

Discovery of a broad-spectrum antiviral activity in self-assembling immunostimulatory duplex RNAs

A new study, published on the bioRxiv* preprint server, has discovered a class of new immunostimulatory RNAs while studying influenza infection-associated host genes in human lung epithelial cells using small interfering RNAs (siRNAs). Scientists revealed that these short duplex RNAs could induce type I and type III interferons (IFN-I/III) in a wide variety of cells.

23 Nov 2021

A novel reverse epitope discovery approach to characterize SARS-CoV-2 public CD4+ αβ T cell clonotypes

A new study, published on the bioRxiv* preprint server, has focused on public clonotypes, i.e., clones found in multiple individuals, for the development of a novel reverse epitope discovery technique. This technique holds greater potential for population-wide applications.

23 Nov 2021

Time of starting antiretroviral therapy can influence tumor development In HIV patients

HIV patients have an increased risk of developing skin and mucosal cancers, even though HIV is no longer detectable in their blood due to antiretroviral therapy.

23 Nov 2021

Strong antibody responses against harmless coronaviruses may protect against SARS-CoV-2

Infections with the novel coronavirus and vaccination lead to strong antibody responses against SARS-CoV-2. Immune responses to other human coronaviruses, which mostly only cause harmless colds, also provide some protection against SARS-CoV-2.

23 Nov 2021

Antigenic cocktail produced in Nicotiana benthamian plant as a potential COVID-19 vaccine candidate

Scientists utilize N. benthamiana for producing the N-protein and an antigenic cocktail containing the N-protein and SARS-CoV-2 S RBD.

23 Nov 2021

Tobacco mosaic virus nanoparticle-based novel COVID-19 vaccine candidate

Scientists generate a VLP type NP platform made of recombinant viral antigens conjugated with TMV virions.

23 Nov 2021

Inactivated virion-based vaccine confers robust cell-mediated immunity against major SARS-CoV-2 variants

Indian researchers determine the magnitude, quality, and persistence of cellular and humoral memory responses after vaccination with BBV152/Covaxin.

23 Nov 2021

WHO’s C-TAP and MPP finalize licensing agreement with CSIC for COVID-19 serological antibody technology

WHO's COVID-19 Technology Access Pool and the Medicines Patent Pool today finalized a licensing agreement with the Spanish National Research Council for a COVID-19 serological antibody technology.

23 Nov 2021

Study shows SARS-CoV-2 can infect and replicate in human iPSC-derived neurons

In a study recently published on the bioRxiv preprint server, researchers attempted to further increase the scope of previous studies in examining SARS-CoV-2 infection of human CNS resident cells.

22 Nov 2021

Characterization of B-cell receptor repertoires in COVID-19 patients

In a new study published in the journal Human Immunology, scientists sought to better understand how B-cell immune repertoire changes over time during SARS-CoV-2 infection by comprehensively characterizing the dynamics of immunoglobin heavy chain (IGH) repertoire in COVID-19 patients.

22 Nov 2021

Novel Lyme disease vaccine may also combat other tick-borne diseases

Yale University researchers have developed a novel vaccine that in guinea pigs offers protection against infection by the bacterium that causes Lyme disease and may also combat other tick-borne diseases, they report Nov. 17 in the journal Science Translational Medicine.

22 Nov 2021

Immune Response News and Research

Study finds rhinovirus reduces SARS-CoV-2 replication in airway epithelial cells

Bat coronavirus ecology, evolution, and spillover

Vaping linked to dysregulation of mitochondrial genes and immune response genes

Limited immune responses three months after Pfizer-BioNTech vaccination among elderly

Vaccine-induced immune responses for SARS-CoV-2 in patients receiving anti-CD20 B-cell depleting therapies

Discovery of a broad-spectrum antiviral activity in self-assembling immunostimulatory duplex RNAs

A novel reverse epitope discovery approach to characterize SARS-CoV-2 public CD4+ αβ T cell clonotypes

Time of starting antiretroviral therapy can influence tumor development In HIV patients

Strong antibody responses against harmless coronaviruses may protect against SARS-CoV-2

Antigenic cocktail produced in Nicotiana benthamian plant as a potential COVID-19 vaccine candidate

Tobacco mosaic virus nanoparticle-based novel COVID-19 vaccine candidate

Inactivated virion-based vaccine confers robust cell-mediated immunity against major SARS-CoV-2 variants

WHO’s C-TAP and MPP finalize licensing agreement with CSIC for COVID-19 serological antibody technology

Study shows SARS-CoV-2 can infect and replicate in human iPSC-derived neurons

Characterization of B-cell receptor repertoires in COVID-19 patients

Novel Lyme disease vaccine may also combat other tick-borne diseases

Paper-based innovations for COVID-19 diagnosis

CoronaVac vaccine booster strengthens protection against SARS-CoV-2

Study explores connections between COVID-19 severity and gene expression in immune cells

U of U Health supports Governor’s decision to authorize COVID-19 booster doses for all adults in Utah

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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