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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Researchers find RNA molecule that interferes with lipoprotein production, reduces hyperlipidemia

Hyperlipidemia, a condition with high levels of fats circulating in the bloodstream, is a known risk factor for various cardiovascular and metabolic disorders. While the Western diet often contributes to high levels of lipids such as cholesterol and triglycerides, over-production of the body's own lipoproteins can lead to hyperlipidemia, independent of food intake.

25 Jun 2013

Infinity announces data from IPI-145 Phase 1 study in patients with advanced hematologic malignancies

Infinity Pharmaceuticals, Inc. today announced Phase 1 data from an ongoing study of IPI-145, its potent, oral inhibitor of phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma in patients with advanced hematologic malignancies, or potentially fatal blood cancers.

25 Jun 2013

Advaxis seeks ADXS-HPV Orphan Drug Designation for treatment of HPV-associated anal cancer

Advaxis, Inc., a leader in developing the next generation of immunotherapies for cancer and infectious diseases, announced that it has submitted an Application for Orphan Drug Designation with the U.S. Food and Drug Administration Office of Orphan Products Development for ADXS-HPV, its lead drug candidate, for the treatment of human papillomavirus-associated anal cancer.

25 Jun 2013

Researchers test modified dendritic cells in patients with melanoma

In this issue of the Journal of Clinical Investigation, researchers led by Scott Pruitt at Duke University and Merck Research Laboratories report on a human clinical trial in which modified dendritic cells, a component of the immune system, were tested in patients with melanoma.

25 Jun 2013

Investigators uncover connection between tumor metabolic process and progression of kidney cancer

Investigators in The Cancer Genome Atlas (TCGA) Research Network have uncovered a connection between how tumor cells use energy from metabolic processes and the aggressiveness of the most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC).

24 Jun 2013

Researchers provide new revelations about intricate pathways involved in turning on T cells

A major study from researchers at the La Jolla Institute for Allergy and Immunology provides new revelations about the intricate pathways involved in turning on T cells, the body's most important disease-fighting cells, and was published today in the prestigious scientific journal Nature.

24 Jun 2013

Researchers discover reason behind failed anti-cancer therapy

Researchers at the Hebrew University of Jerusalem and in California have achieved a breakthrough in understanding how and why a promising anti-cancer therapy has failed to achieve hoped-for success in killing tumor cells.

24 Jun 2013

Th17 lymphocyte: The master coordinator of cellular inflammation in vessel wall

Every year, more than 16,000 Americans die as a result of what's known as an "aortic dissection" - a catastrophic rupture of the aorta, the body's largest artery. Once thought to be a simple structural failure, aortic dissection is now understood to be caused by an inflammatory process that weakens the artery's walls.

21 Jun 2013

Alnylam presents new pre-clinical data of ALN-CC5 for treatment of complement-mediated diseases

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it has presented new pre-clinical data with ALN-CC5, an RNAi therapeutic targeting complement component C5.

21 Jun 2013

MPIIB researchers show that Chlamydia infections can cause mutations in host DNA

Chlamydia trachomatis is a human pathogen that is the leading cause of bacterial sexually transmitted disease worldwide with more than 90 million new cases of genital infections occurring each year. About 70 percent of women infected with Chlamydia remain asymptomatic and these bacteria can establish chronic infections for months, or even years. Even when it causes no symptoms, Chlamydia can damage a woman's reproductive organs. In addition, standard antibacterial drugs are proving increasingly ineffective in complete eradication, as Chlamydia goes in to persistent mode, leading to asymptomatic chronic infection.

21 Jun 2013

Researchers report therapeutic strategy that appears to destroy drug-resistant melanomas

An advanced tumor is a complex ecosystem. Though derived from a single cell, it evolves as it grows until it contains several subspecies of cells that vary dramatically in their genetic traits and behaviors.

21 Jun 2013

Research findings suggest potent new therapeutic target for certain types of cancer

Scientists have discovered the survival secret to a genetic mutation that stokes leukemia cells, solving an evolutionary riddle and paving the way to a highly targeted therapy for leukemia.

21 Jun 2013

Scientists use stem-cell technology to create research cell line from PDAC patient

Pancreatic cancer carries a dismal prognosis. According to the National Cancer Institute, the overall five-year relative survival for 2003-2009 was 6 percent.

21 Jun 2013

MIT study shows that SIRT1 gene plays key role in controlling circadian rhythms

Human sleeping and waking patterns are largely governed by an internal circadian clock that corresponds closely with the 24-hour cycle of light and darkness. This circadian clock also controls other body functions, such as metabolism and temperature regulation.

21 Jun 2013

New model developed to predict atrial fibrillation stroke risk factors

A more accurate and reliable stroke prediction model has been developed to help physicians decide whether to start blood-thinning treatment for patients with atrial fibrillation, as described in the current online issue of the Journal of the American Heart Association.

21 Jun 2013

Researchers receive NIH grant to study key proteins linked to cancer and diabetes

Researchers from the Polytechnic Institute of New York University and NYU have received a grant from the National Institutes of Health (NIH) to further a novel approach to understanding the genetic underpinnings of diseases including cancer and diabetes.

21 Jun 2013

Researchers discover key role of RAP1 gene in obesity

The discovery of an unexpected function for a gene that was associated to another process in the organism might be a solution in search of a problem, a clue to unsuspected connections. That is what has happened with RAP1, a gene that protects telomeres- the ends of chromosomes-after researchers from the Spanish National Cancer Research Centre surprisingly discovered its key role in obesity.

21 Jun 2013

PTC Therapeutics announces pricing of its initial public offering

PTC Therapeutics, Inc. (PTC) today announced the pricing of its initial public offering of 8,372,000 shares of common stock at a public offering price of $15.00 per share, before underwriting discounts. All of the shares in the offering are being sold by PTC.

20 Jun 2013

Banyan Biomarkers completes $6 million series A funding for further biomarker research

Banyan Biomarkers, Inc. today announced that it has completed a $6 million series A funding from private investors for further biomarker research and continued development of a traumatic brain injury (TBI) diagnostic test. Currently, the company is enrolling subjects in a 2,000 patient pivotal clinical trial funded by a $26.3 million contract with the United States Department of Defense.

20 Jun 2013

New variety of canary seeds ideal for people with celiac disease

A new variety of canary seeds bred specifically for human consumption qualifies as a gluten-free cereal that would be ideal for people with celiac disease (CD), scientists have confirmed in a study published in ACS' Journal of Agricultural and Food Chemistry.

20 Jun 2013

Protein News and Research

Further Reading

Researchers find RNA molecule that interferes with lipoprotein production, reduces hyperlipidemia

Infinity announces data from IPI-145 Phase 1 study in patients with advanced hematologic malignancies

Advaxis seeks ADXS-HPV Orphan Drug Designation for treatment of HPV-associated anal cancer

Researchers test modified dendritic cells in patients with melanoma

Investigators uncover connection between tumor metabolic process and progression of kidney cancer

Researchers provide new revelations about intricate pathways involved in turning on T cells

Researchers discover reason behind failed anti-cancer therapy

Th17 lymphocyte: The master coordinator of cellular inflammation in vessel wall

Alnylam presents new pre-clinical data of ALN-CC5 for treatment of complement-mediated diseases

MPIIB researchers show that Chlamydia infections can cause mutations in host DNA

Researchers report therapeutic strategy that appears to destroy drug-resistant melanomas

Research findings suggest potent new therapeutic target for certain types of cancer

Scientists use stem-cell technology to create research cell line from PDAC patient

MIT study shows that SIRT1 gene plays key role in controlling circadian rhythms

New model developed to predict atrial fibrillation stroke risk factors

Researchers receive NIH grant to study key proteins linked to cancer and diabetes

Researchers discover key role of RAP1 gene in obesity

PTC Therapeutics announces pricing of its initial public offering

Banyan Biomarkers completes $6 million series A funding for further biomarker research

New variety of canary seeds ideal for people with celiac disease

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