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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Study: Heart rate turbulence is linked with increased risk of death from cardiovascular disease

Abnormal heart rate turbulence is associated with an increased risk of heart disease death in otherwise low-risk older individuals, according to a study funded by the National Heart, Lung, and Blood Institute, part of the National Institutes of Health.

15 Feb 2011

The Lancet publishes Baxter's PREFLUCEL phase III trial results against seasonal influenza

Baxter International Inc. announced today results of a study published in this week's issue of The Lancet that demonstrate effectiveness and tolerability of Baxter's PREFLUCEL in protecting against seasonal influenza.

From Baxter International Inc. 15 Feb 2011

RPCI offers first FDA-approved cancer treatment vaccine

The nation's first FDA-approved cancer treatment vaccine, Provenge, is being offered for the first time in Western New York at Roswell Park Cancer Institute.

15 Feb 2011

Raptor reopens enrollment in DR Cysteamine Phase 3 trial to treat patients with nephropathic cystinosis

Raptor Pharmaceutical Corp., today announced it has reopened enrollment in its Phase 3 clinical trial of its proprietary delayed-release oral formulation of cysteamine bitartrate in patients with nephropathic cystinosis.

15 Feb 2011

Research: MEF2D protein in mitochondria appears to contribute early steps in Parkinson's disease

For the last several years, neurologists have been probing a connection between Parkinson's disease and problems with mitochondria, the miniature power plants of the cell.

15 Feb 2011

Idera: IMO-3100 in lupus preclinical model suppressed several key disease progression parameters

Idera Pharmaceuticals, Inc. announced today that it is presenting data on IMO-3100, an antagonist of TLR7 and TLR9, in a preclinical model of lupus showing that treatment with IMO-3100 suppressed several key disease progression parameters.

15 Feb 2011

Scientists suggest combinational therapy can improve treatment of solid tumors

Most, if not all, solid tumors contain regions that are not well oxygenated. Tumor cells in these regions, which are known as hypoxic regions, are usually resistant to the death-inducing effects of chemotherapeutics. But now, Caroline Dive and colleagues, at Manchester University, United Kingdom, have identified a compound that induces human cancer cells exposed to hypoxic conditions in vitro to undergo a form of cell death known as apoptosis.

15 Feb 2011

New research finds differences in cell fate commitment during embryonic development in mammals

New research shows that all not mammals are created equal. In fact, this work shows that the animals most commonly used by scientists to study mammalian genetics -- mice -- develop unusually quickly and may not always be representative of embryonic development in other mammals.

15 Feb 2011

Scientists find molecular pathway that offers novel targets for diabetes therapies

Once people develop type 2 diabetes, high blood glucose levels alter their metabolism so much that it becomes difficult to sift through all the clues to find what might enable the disease.

15 Feb 2011

Researchers use computers to capture chemical signal structure that triggers metastatic cancer

In cancer and other pathological diseases, researchers are discovering that packaging is important: specifically, how DNA - about two meters long when unwound and stretched - coils up and compacts neatly inside the nucleus of a cell.

15 Feb 2011

Hunk protein inhibition might provide new approach to treat HER2-positive breast cancer

Among women with breast cancer, approximately 25% have a subtype that is characterized by high levels of expression of the protein HER2. HER2-positive breast cancer tends to be more aggressive than other breast cancer subtypes.

15 Feb 2011

Researcher discovers mechanism how p53 human genome gets inactivated in cancerous cells

One of the most important genes in the human genome is called p53 and its function is to suppress tumours, according to Roger Leng, a researcher in the Faculty of Medicine & Dentistry. Leng has discovered the mechanism by which p53 is inactivated in cancerous cells, allowing tumours to grow.

15 Feb 2011

Molecular helper Spy aids designer bacteria to produce large quantities of stable, functional proteins

Scientists have discovered a molecular assistant called Spy that helps bacteria excel at producing proteins for medical and industrial purposes.

15 Feb 2011

State court jury rules in favor of Merck in FOSAMAX trial

Merck & Co., Inc. today said a state court jury in New Jersey found in its favor in the Rosenberg v. Merck case, rejecting the claims of a woman who blamed her dental and jaw related problems on her FOSAMAX use.

15 Feb 2011

Affymetrix introduces NG Class Detergents to advance study of integral membrane proteins

Affymetrix, Inc. today launched its Anatrace® brand Neopentyl Glycol (NG) Class™ Detergents, the next generation of detergents to significantly advance the study of integral membrane proteins (IMPs), the most important proteins found in the human genome.

14 Feb 2011

PROLOR reports positive DSMB review of long-acting human growth hormone clinical trial

PROLOR Biotech, Inc., a company developing next generation biobetter therapeutic proteins, today reported that patient enrollment and dosing in the Phase II trial of its long-acting version of human growth hormone (hGH-CTP) are proceeding according to plan, with study completion targeted for mid-year 2011.

14 Feb 2011

Independent Safety Monitoring Board recommends Vical's Allovectin-7 Phase 3 trial to continue as per protocol

Vical Incorporated today announced that an independent Safety Monitoring Board (SMB) for the company's Phase 3 trial of Allovectin-7® in patients with metastatic melanoma has completed the trial's fifth scheduled safety analysis and recommended that the trial continue per the protocol.

14 Feb 2011

Study shows beneficial anti-fibrotic effects of Pentraxin-2 in idiopathic pulmonary fibrosis

Promedior, Inc., a clinical stage biotechnology company developing novel therapies to treat fibrotic and inflammatory diseases, announced today the publication of collaborative research in the International Journal of Biochemistry and Cell Biology entitled, "TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P."

14 Feb 2011

Novel technology to diagnose Alzheimer's disease before symptoms appear

UT Southwestern Medical Center scientists have helped develop a novel technology to diagnose Alzheimer's disease from blood samples long before symptoms appear.

14 Feb 2011

Rising number of livestock diseases threatens public health, food security in developing countries, report says

"A growing number of livestock, such as cows and pigs, are fuelling new animal epidemics worldwide and posing more severe problems in developing countries as it threatens their food security, according to a report [.pdf] released on Friday" during an international conference in New Delhi, India, on Leveraging Agriculture for Improving Nutrition & Health, Reuters reports (Lyn, 2/11).

14 Feb 2011

Protein News and Research

Further Reading

Study: Heart rate turbulence is linked with increased risk of death from cardiovascular disease

The Lancet publishes Baxter's PREFLUCEL phase III trial results against seasonal influenza

RPCI offers first FDA-approved cancer treatment vaccine

Raptor reopens enrollment in DR Cysteamine Phase 3 trial to treat patients with nephropathic cystinosis

Research: MEF2D protein in mitochondria appears to contribute early steps in Parkinson's disease

Idera: IMO-3100 in lupus preclinical model suppressed several key disease progression parameters

Scientists suggest combinational therapy can improve treatment of solid tumors

New research finds differences in cell fate commitment during embryonic development in mammals

Scientists find molecular pathway that offers novel targets for diabetes therapies

Researchers use computers to capture chemical signal structure that triggers metastatic cancer

Hunk protein inhibition might provide new approach to treat HER2-positive breast cancer

Researcher discovers mechanism how p53 human genome gets inactivated in cancerous cells

Molecular helper Spy aids designer bacteria to produce large quantities of stable, functional proteins

State court jury rules in favor of Merck in FOSAMAX trial

Affymetrix introduces NG Class Detergents to advance study of integral membrane proteins

PROLOR reports positive DSMB review of long-acting human growth hormone clinical trial

Independent Safety Monitoring Board recommends Vical's Allovectin-7 Phase 3 trial to continue as per protocol

Study shows beneficial anti-fibrotic effects of Pentraxin-2 in idiopathic pulmonary fibrosis

Novel technology to diagnose Alzheimer's disease before symptoms appear

Rising number of livestock diseases threatens public health, food security in developing countries, report says

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Why use light scattering to analyze proteins and viral vectors?

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