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Johns Hopkins researchers develop new way to deliver sight-saving gene therapy to the retina

In experiments with rats, pigs and monkeys, Johns Hopkins Medicine researchers have developed a way to deliver sight-saving gene therapy to the retina.

From Johns Hopkins Medicine 30 Sep 2019

High-risk surgical patients with severe aortic stenosis can benefit from new TAVR system

The Portico IDE study found that 30-day safety and one-year effectiveness outcomes of a novel self-expanding transcatheter aortic valve replacement (TAVR) system for patients with severe aortic stenosis (AS) at high or extreme-risk for surgery was noninferior to contemporary FDA-approved TAVR systems available in the United States.

30 Sep 2019

Antibiotic-resistant bacteria could be transmitted via the washing machine

Hygienists of the University of Bonn prove a transmission to newborns. Consequences for the domestic environment?

30 Sep 2019

Study: Revascularization with PCI or CABG prolongs survival in patients with left main disease

Patients with left main coronary artery disease (LMCAD) typically have a poor prognosis due to the large amount of myocardium at risk.

30 Sep 2019

Polymer drug-eluting and polymer-free drug-coated stents safe and effective for patients with high bleeding risk

The first randomized trial to compare a durable polymer drug-eluting stent to a polymer-free drug-coated stent in patients at high risk of bleeding and treated with one-month dual antiplatelet therapy (DAPT) found that both are clinically safe and effective.

27 Sep 2019

IDEAL LM study: Biodegradable polymer everolimus-eluting stent safe and effective for patients undergoing PCI

New data from the IDEAL-LM trial found that a biodegradable polymer everolimus-eluting stent (BP-EES) followed by four months of dual antiplatelet therapy (DAPT) was safe and effective compared to a conventional durable polymer everolimus-eluting stent (DP-EES) followed by 12 months of DAPT in patients undergoing PCI for unprotected left main coronary artery (uLMCA) disease.

27 Sep 2019

Ticagrelor monotherapy reduces bleeding while preserving ischemic benefit in high-risk PCI patients

New data from the randomized, placebo-controlled TWILIGHT trial found that compared to ticagrelor plus aspirin, ticagrelor monotherapy reduces bleeding events without increasing the risk of death, myocardial infarction, or stroke in high-risk patients who have undergone successful percutaneous coronary intervention and completed three months of dual antiplatelet therapy.

27 Sep 2019

Shorter duration DAPT after PCI did not increase adverse events in high-bleeding risk patients, finds study

Data from the EVOLVE Short DAPT study found that shortened three-month dual antiplatelet therapy did not increase myocardial infarction or stent thrombosis in high bleeding risk patients treated with a contemporary drug-eluting stent.

27 Sep 2019

High-risk heart patients may not require long-term aspirin use after stent placement

High-risk patients undergoing coronary stent procedures may not require long-term aspirin use after stent placement, Mount Sinai researchers report in a groundbreaking study

26 Sep 2019

Physiologists, researchers to discuss factors underlying cardiovascular disease at APS conference

International physiologists and researchers studying the kidney, high blood pressure and related medical conditions will convene next week at the American Physiological Society (APS) Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference in Estes Park, Colo.

25 Sep 2019

Mummies show atherosclerosis was prevalent in ancient times

A new study published in the American Heart Journal used spectroscopic imaging techniques to ‘see’ fatty plaques in the arteries of ancient mummies. This shows that the people of ancient times also had a high incidence of clogged arteries, showing that heart disease is of very old lineage.

24 Sep 2019

New microcapsules provide safe and effective delivery of drugs, biomolecules

Cracking an egg to release its yolk requires applying external force (like being smacked against the edge of a bowl) to overcome the strength of the eggshell.

24 Sep 2019

Heart disease was bigger issue for human ancestors than originally thought, study reveals

A new imaging study of the mummified arteries of people who lived thousands of years ago revealed that their arteries were more clogged than originally thought, according to a proof-of-concept study led by a researcher with The University of Texas Health Science Center at Houston.

23 Sep 2019

Study finds no clear link between cancer incidence and local food in glassworks areas

There is no clear link between cancer incidence and locally produced food from an area with a history of glass manufacture with contaminated soil, according to a new study from, among others, Linköping University in Sweden.

23 Sep 2019

Electric baseball cap may help to reverse male pattern balding

Researchers have developed an electric patch that stimulates hair growth to help reverse male balding. The patch has now been embedded in a baseball cap.

23 Sep 2019

New study identifies potential enzyme target for diabetic retinopathy

A new study shows that diabetic retinopathy (DR), or retinal disease caused by the high blood glucose levels in diabetes mellitus, is due to the death of retinal cells because of the high levels of a pro-enzyme called lysyl oxidase propeptide (LOX-PP). This could help researchers develop specific treatments by targeting this molecule.

22 Sep 2019

Vascular News and Research

Johns Hopkins researchers develop new way to deliver sight-saving gene therapy to the retina

High-risk surgical patients with severe aortic stenosis can benefit from new TAVR system

Antibiotic-resistant bacteria could be transmitted via the washing machine

Study: Revascularization with PCI or CABG prolongs survival in patients with left main disease

Polymer drug-eluting and polymer-free drug-coated stents safe and effective for patients with high bleeding risk

IDEAL LM study: Biodegradable polymer everolimus-eluting stent safe and effective for patients undergoing PCI

Ticagrelor monotherapy reduces bleeding while preserving ischemic benefit in high-risk PCI patients

Shorter duration DAPT after PCI did not increase adverse events in high-bleeding risk patients, finds study

High-risk heart patients may not require long-term aspirin use after stent placement

Physiologists, researchers to discuss factors underlying cardiovascular disease at APS conference

Mummies show atherosclerosis was prevalent in ancient times

New microcapsules provide safe and effective delivery of drugs, biomolecules

Heart disease was bigger issue for human ancestors than originally thought, study reveals

Study finds no clear link between cancer incidence and local food in glassworks areas

Electric baseball cap may help to reverse male pattern balding

New study identifies potential enzyme target for diabetic retinopathy

Researchers discover potential approach to treating diabetic retinopathy

Sponge-like action of circular RNA aids tissue repair after heart attack

Researchers find potential new treatment for diabetic retinopathy

BUSM researchers develop advanced protocol to improve gene therapy tool production

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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