Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Dual-functional Qx-D scaffolds hold immense promise for treating infected bone defects

In the realm of orthopedic medicine, the challenge of managing infected bone defects (IBDs) has persisted as a significant hurdle.

24 Dec 2024

Solving a decades-long puzzle in leishmaniasis drug development

A breakthrough in understanding how a single-cell parasite makes ergosterol (its version of cholesterol) could lead to more effective drugs for human leishmaniasis, a parasitic disease that afflicts about 1 million people and kills about 30,000 people around the world every year.

20 Dec 2024

Kaempferol boosts immune tolerance and fights allergies

Kaempferol's role in Treg development is linked to Aldh1a2 activation in dendritic cells, highlighting its potential in suppressing inflammation and allergies.

19 Dec 2024

Huntsman Cancer Institute joins innovative clinical trials program for blood cancers

Huntsman Cancer Institute at the University of Utah (the U) has joined other institutions in an innovative clinical trials program designed to match patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) with a clinical trial specifically designed for the genetic signature of their disease.

17 Dec 2024

WashU Medicine receives $10.8 million grant to advance blood cancer research

Continuing its role as a leader in leukemia research, Washington University School of Medicine in St. Louis has been awarded a five-year, $10.8 million grant to further its exceptional programs in leukemia and other blood cancers.

16 Dec 2024

Gene variant in Andean populations could help predict blood cancer treatment outcomes

Two researchers from Huntsman Cancer Institute at the University of Utah (the U) have discovered a gene variant found in high-altitude Andean populations that they believe could be a new biomarker for predicting the severity of diseases and treatment responses for certain types of blood cancer.

14 Dec 2024

Skin as an immune hero: Fighting infections with self-made antibodies

Researchers uncover how the skin autonomously produces antibodies through specialized immune structures, maintaining microbial balance and preventing infections.

12 Dec 2024

High-dose chemotherapy followed by autologous stem cell transplant ineffective for patients with mantle cell lymphoma

Late-breaking research reveals there is no benefit from high-dose chemotherapy followed by autologous stem cell transplant (ASCT) for patients with mantle cell lymphoma (MCL) in remission following their initial treatment.

11 Dec 2024

Daratumumab treatment shows promise for high-risk smoldering multiple myeloma in phase 3 trial

A new treatment is showing promise for people with high-risk smoldering multiple myeloma (SMM).

10 Dec 2024

Researchers find brain-body immune link in the dural sinuses and skull marrow

New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London provides valuable insights into the brain-body immune connection identifying key communication hubs in the dural sinuses and skull bone marrow at the back of the head.

10 Dec 2024

New triplet therapies show promise for relapsed and newly diagnosed leukemias

Three clinical trials led by researchers from The University of Texas MD Anderson Cancer Center demonstrated significant positive results from novel triplet therapies in the treatment of relapsed or refractory and newly diagnosed leukemias.

9 Dec 2024

Smoking linked to increased genetic mutations in myelodysplastic syndromes

Smokers with myelodysplastic syndromes (MDS) or a precursor condition had elevated levels of genetic mutations linked to the disease, a new study shows.

9 Dec 2024

New advances offer hope for patients with systemic mastocytosis

Dana-Farber Cancer Institute researchers are breaking new ground in the fight against systemic mastocytosis, a rare and heterogeneous condition that is often challenging for clinicians to accurately diagnose and treat.

9 Dec 2024

New insights into survival of breast cancer cells in the bone marrow

A study from researchers at the University of Michigan and the University of California San Diego has shed light on a previously poorly understood aspect of breast cancer recurrence: how cancer cells survive in bone marrow despite targeted therapies.

4 Dec 2024

SARS-CoV-2 spike protein found lingering in brain regions

Researchers find that SARS-CoV-2 spike protein persists in the skull-meninges-brain axis, driving neuroinflammation, neurodegeneration, and heightened vulnerability to brain injuries.

3 Dec 2024

New study explores obecabtagene autoleucel for adults with hard-to-treat leukemia

FELIX study results reveal obe-cel's potential in relapsed B-cell ALL, achieving 77% remission with low severe toxicity, enhancing CAR T-cell therapy outcomes.

2 Dec 2024

Scientists identify drug-resistant bone marrow cells linked to poor outcomes in fast-growing leukemia

Researchers explore treatment resistance and relapse in T-cell acute lymphoblastic leukemia.

29 Nov 2024

Obe-cel demonstrates strong efficacy and safety in treating leukemia

Patients with relapsed or refractory CD19-positive B-cell acute lymphoblastic leukemia (ALL) who were treated with the novel anti-CD19 chimeric antigen receptor (CAR) T cell therapy, obecabtagene autoleucel (obe-cel), experienced high response rates and most did not need a subsequent stem cell transplant (SCT), according to results from the Phase Ib/II FELIX trial co-led by researchers at The University of Texas MD Anderson Cancer Center.

27 Nov 2024

Epigenetic profiles of blood cancer cells could aid in diagnosis and treatment

Research in biomedical laboratories has been changing significantly in recent years, to the point that test tubes have given way to computers on many occasions.

27 Nov 2024