Ligand News and Research

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Breaking barriers: hydrogel reservoir unleashes the potential of HSV-1 virotherapy in cancer

Researchers evaluated the therapeutic efficacy of Navoximod.

13 Jun 2023

Bamboo's hidden treasures: unveiling the possible health-boosting powers of leaf and sheath extracts

Researchers explored the antioxidant and anti-inflammatory properties of bamboo leaves and sheaths.

13 Jun 2023

Revolution in neuroscience: 2D nanomaterials propel advances in brain repair, treatment, and diagnosis

Review discusses the increasing importance of two-dimensional nanomaterials like graphene in neuroscience, highlighting their potential in nerve repair, creating brain-mimicking synaptic devices, and treating neurological disorders. It also considers the challenges and future prospects of these materials in this complex field.

11 Jun 2023

New process can help to design drugs with fewer or no side effects

Have you ever wondered how drugs reach their targets and achieve their function within our bodies? If a drug molecule or a ligand is a message, an inbox is typically a receptor in the cell membrane.

7 Jun 2023

New folate-targeting magnetic microrobot system shows great potential in cancer treatment

The limited ability of microrobots to assist drugs in entering cells hinders their therapeutic efficacy. To address this, the cancer-targeting molecule folic acid (FA) was introduced to microrobots to promote drug uptake by cancer cells via receptor-ligand-mediated endocytosis.

6 Jun 2023

A SARS-CoV-2 spike-targeting bispecific T-cell engager strategy for controlling SARS-CoV-2 infection

Researchers described a novel strategy for controlling severe acute respiratory syndrome coronavirus 2.

5 Jun 2023

Multiple sclerosis: Immune cell invasion enabled by blood-brain barrier breakdown

Blood-brain barrier breakdown in multiple sclerosis leads to immune cell infiltration into the central nervous system. Antigen presentation at the barrier promotes CD8+ T cell entry, triggering focal breakdown and hindering their invasion.

4 Jun 2023

How does a riboswitch regulate its own synthesis?

To prevent a global health crisis, scientists around the world are searching for ways to fight bacteria that can evade the current arsenal of antibiotics.

2 Jun 2023

Lipid-degrading enzyme, fatty acid amide hydrolase is a predictor of long-term survival in patients with breast cancer

Scientists have identified a lipid-degrading enzyme as a prognostic biomarker for luminal breast cancer.

31 May 2023

T-cell-inducing mRNA COVID-19 vaccine improves effectiveness

Researchers develop a lipid nanoparticle-formulated mRNA-based antigen encoding three SARS-CoV-2 peptides derived from non-structural proteins.

25 May 2023

COVID-19 'bites the apple': Abdominal obesity ignites cytokine storm

Abdominal obesity increases the risk of severe COVID-19 and mortality due to heightened inflammatory responses, according to a study on Japanese patients and a murine COVID-19 model. Blocking inflammatory cytokines and preventing obesity may improve survival rates.

24 May 2023

National-level comprehensive mapping of high-fatality SARS-CoV-2 outbreaks in nursing homes

Researchers analyzed data from three SARS-CoV-2 outbreaks among nursing homes in Belgium.

24 May 2023

Looking at cancer drugs to help put the brakes on classic indicators of aging

Antiretroviral cocktails can make human immunodeficiency virus, or HIV, undetectable and untransmittable, but both the virus and its treatment can also accelerate aging of bone and muscle.

24 May 2023

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

Researchers derived peptides from the SARS-CoV-2 spike protein to assess COVID-19-associated inflammatory changes using zebrafish models.

19 May 2023

Researchers report the role of RNA-binding protein Msi 1 to maintain breast cancer stem cells

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 9, entitled, "Increased expression of musashi 1 on breast cancer cells has implication to understand dormancy and survival in bone marrow."

16 May 2023

Boosting gut health with short-chain fatty acids

Research paper provides an overview of short-chain fatty acids (SCFAs) and their role in regulating gut homeostasis. It also discusses SCFA-producing bacteria and potential therapeutic approaches to boost SCFA levels in the gut to treat related diseases.

9 May 2023

Ligand News and Research

Breaking barriers: hydrogel reservoir unleashes the potential of HSV-1 virotherapy in cancer

Bamboo's hidden treasures: unveiling the possible health-boosting powers of leaf and sheath extracts

Revolution in neuroscience: 2D nanomaterials propel advances in brain repair, treatment, and diagnosis

New process can help to design drugs with fewer or no side effects

New folate-targeting magnetic microrobot system shows great potential in cancer treatment

A SARS-CoV-2 spike-targeting bispecific T-cell engager strategy for controlling SARS-CoV-2 infection

Multiple sclerosis: Immune cell invasion enabled by blood-brain barrier breakdown

How does a riboswitch regulate its own synthesis?

Lipid-degrading enzyme, fatty acid amide hydrolase is a predictor of long-term survival in patients with breast cancer

T-cell-inducing mRNA COVID-19 vaccine improves effectiveness

COVID-19 'bites the apple': Abdominal obesity ignites cytokine storm

National-level comprehensive mapping of high-fatality SARS-CoV-2 outbreaks in nursing homes

Looking at cancer drugs to help put the brakes on classic indicators of aging

A novel role for macrophage-activation signaling in orchestrating the recruitment process in response to the SARS-CoV-2 spike protein

Researchers report the role of RNA-binding protein Msi 1 to maintain breast cancer stem cells

Boosting gut health with short-chain fatty acids

Cancer-fighting immune cells can fuel their ability to attack tumors

Researchers identify a potential safer route to pain relief

Can smoking cigarettes alter your bone structure?

Study identifies immune signature to predict severe COVID-19 in cardiovascular patients

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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