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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Researchers define structure of Cdc13 protein in yeast

Chromosomes - long, linear DNA molecules - are capped at their ends with special DNA structures called telomeres and an assortment of proteins, which together act as a protective sheath. Telomeres are maintained through the interactions between an enzyme, telomerase, and several accessory proteins. Researchers at The Wistar Institute have defined the structure of one of these critical proteins in yeast.

22 Nov 2012

Medgenics’ EPODURE Biopump technology for EPO delivery receives U.S. patent

Medgenics, Inc., the developer of BiopumpTM a novel technology for the sustained production and delivery of therapeutic proteins in patients using their own tissue, today announced a patent granted by the U.S. Patent and Trademark Office (USPTO) protecting the use of Medgenics' EPODURE Biopump technology for delivery of erythropoietin (EPO).

22 Nov 2012

Obesity and oxidative stress: an interview with Dr Elizabeth New

Even though oxygen is essential for us to live, it can react with other compounds in the body to produce molecules called free radicals, which are highly reactive and damaging.

22 Nov 2012

New approach could help orthopaedic surgeons better deal with battlefield injuries

Bones are resilient and heal well after most fractures. But in cases of traumatic injury, in which big pieces of bone are missing, healing is much more difficult, if not impossible. These so-called "large segmental defects" are a major clinical problem, and orthopaedic surgeons struggle to treat them, especially among the military in places like Afghanistan.

22 Nov 2012

IRCM researchers discover a nerve cell's internal clock

A team of IRCM researchers, led by Dr. Fr-d-ric Charron, recently uncovered a nerve cell's internal clock, used during embryonic development.

22 Nov 2012

Crucial link between protein synthesis and autism spectrum disorders

Researchers from McGill University and the University of Montreal have identified a crucial link between protein synthesis and autism spectrum disorders (ASD), which can bolster new therapeutic avenues.

22 Nov 2012

Heidelberg researchers uncover function of specific molecular chaperones

Clumped proteins can be dissolved with the aid of cellular repair systems - a process of critical importance for cell survival especially under conditions of stress. Heidelberg researchers have now decrypted the fundamental mechanism for dissolving protein aggregates that involves specific molecular chaperones.

22 Nov 2012

Homing beacon drugs can kill cancer cells

A medical researcher with the University of Alberta and his team just published their findings about their work on developing 'homing beacon drugs' that kill only cancer cells, not healthy ones, thanks to nano-technology.

22 Nov 2012

UPR pathway helps tumor cells escape apoptosis during development of lymphoma

A pathway called the "Unfolded Protein Response," or UPR, a cell's way of responding to unfolded and misfolded proteins, helps tumor cells escape programmed cell death during the development of lymphoma.

21 Nov 2012

No differences between computer-navigated and traditional TKA related to knee function, pain

For many years, the use of computer-assisted navigation has been touted as improving the positioning, sizing and alignment of replacement knee joints, resulting in greater durability of joints and overall improvement in patient movement. However, new research published in the Journal of Bone and Joint Surgery (JBJS) found no difference in knee function, alignment or durability/survivorship between joints positioned and completed with the help of computer navigation, and those replaced with conventional total knee arthroplasty (TKA) procedures.

21 Nov 2012

Scientists uncover new role for TLR4 in development of tissue fibrosis or scarring

An international multi-disciplinary research team led by Northwestern Medicine scientists has uncovered a new role for the protein toll-like receptor 4 (TLR4) in the development of tissue fibrosis, or scarring.

21 Nov 2012

Acetylon's ective histone deacetylase inhibitors to be showcased at 54th ASH annual meeting

Acetylon Pharmaceuticals Inc., a leader in targeted epigenetic drug discovery and development for enhanced therapeutic outcomes, today announced that its selective histone deacetylase (HDAC) inhibitors will be featured in five posters and one oral presentation at the 54th Annual Meeting of the American Society of Hematology (ASH), taking place December 8-11, 2012, in Atlanta, Georgia.

21 Nov 2012

Scientists extract recent drug trials to tackle Alzheimer's earlier than ever before

Alzheimer's therapeutic trials have gotten bad press lately, but it is not all gloom and doom. As evident at the 5th Clinical Trials in Alzheimer's Disease (CTAD) conference, held 29-31 October in the Principality of Monaco, scientists keep extracting new data from recent drug trials to gear up for a round of new ones that aim to tackle Alzheimer's earlier than ever before.

21 Nov 2012

Novel test reveals rate of progression of amyotrophic lateral sclerosis in patients

A novel test that measures proteins from nerve damage that are deposited in blood and spinal fluid reveals the rate of progression of amyotrophic lateral sclerosis (ALS) in patients, according to researchers from Mayo Clinic's campus in Florida, Emory University and the University of Florida.

21 Nov 2012

Study: 2-PMPA improves cognition in mice with MS

Johns Hopkins researchers report the successful use of a form of MRI to identify what appears to be a key biochemical marker for cognitive impairment in the brains of people with multiple sclerosis (MS). In follow-up experiments on mice with a rodent form of MS, researchers were able to use an experimental compound to manipulate that same marker and dramatically improve learning and memory.

21 Nov 2012

Novel technology can lead to more efficient and cheaper therapy for Pompe disease

VIB researchers from UGent and Vrije Universiteit Brussel , together with a team of the firm Oxyrane have developed a new technology that can lead to a more efficient and possibly also cheaper therapy for diseases such as Pompe disease. Oxyrane will now start developing a clinical program for this therapy in Pompe disease.

21 Nov 2012

Small non-coding RNA715 plays an important role in regulating myelin formation in the CNS

Scientists at the Mainz University Medical Center have discovered another molecule that plays an important role in regulating myelin formation in the central nervous system.

21 Nov 2012

Synthetic membrane channels can be constructed through DNA nanotechnology

As reported in the journal Science, physicists at the Technische Universitaet Muenchen (TUM) and the University of Michigan have shown that synthetic membrane channels can be constructed through "DNA nanotechnology."

21 Nov 2012

Pfizer, Bristol-Myers Squibb receive EC approval for ELIQUIS to prevent NVAF-related stroke

Bristol-Myers Squibb and Pfizer announced today that the European Commission has approved ELIQUIS (apixaban) for prevention of stroke and systemic embolism in adult patients with nonvalvular atrial fibrillation (NVAF) with one or more risk factors.

21 Nov 2012

New insights into what causes uncontrollable bleeding in hemophilia patients

New insights into what causes uncontrollable bleeding in hemophilia patients are provided in a study published by Cell Press on November 20th in the Biophysical Journal. By revealing that blood clots spread in traveling waves through vessels, the study offers new strategies that could lead to the development of more effective treatments for hemophilia as well as common cardiovascular disorders.

20 Nov 2012

Protein News and Research

Further Reading

Researchers define structure of Cdc13 protein in yeast

Medgenics’ EPODURE Biopump technology for EPO delivery receives U.S. patent

Obesity and oxidative stress: an interview with Dr Elizabeth New

New approach could help orthopaedic surgeons better deal with battlefield injuries

IRCM researchers discover a nerve cell's internal clock

Crucial link between protein synthesis and autism spectrum disorders

Heidelberg researchers uncover function of specific molecular chaperones

Homing beacon drugs can kill cancer cells

UPR pathway helps tumor cells escape apoptosis during development of lymphoma

No differences between computer-navigated and traditional TKA related to knee function, pain

Scientists uncover new role for TLR4 in development of tissue fibrosis or scarring

Acetylon's ective histone deacetylase inhibitors to be showcased at 54th ASH annual meeting

Scientists extract recent drug trials to tackle Alzheimer's earlier than ever before

Novel test reveals rate of progression of amyotrophic lateral sclerosis in patients

Study: 2-PMPA improves cognition in mice with MS

Novel technology can lead to more efficient and cheaper therapy for Pompe disease

Small non-coding RNA715 plays an important role in regulating myelin formation in the CNS

Synthetic membrane channels can be constructed through DNA nanotechnology

Pfizer, Bristol-Myers Squibb receive EC approval for ELIQUIS to prevent NVAF-related stroke

New insights into what causes uncontrollable bleeding in hemophilia patients

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