Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

FibroGen receives FDA Orphan Drug Designation for FG-3019 to treat IPF

FibroGen, Inc., today announced that FG-3019, the Company's human monoclonal antibody against connective tissue growth factor (CTGF), has been granted Orphan Drug Designation by the U.S. Food and Drug Administration (FDA) for the treatment of idiopathic pulmonary fibrosis (IPF).

31 Jul 2012

Latrepirdine appears effective in treating Alzheimer's disease in animals

An international team of scientists led by researchers at Mount Sinai School Medicine have discovered that a drug that had previously yielded conflicting results in clinical trials for Alzheimer's disease effectively stopped the progression of memory deterioration and brain pathology in mouse models of early stage Alzheimer's disease.

31 Jul 2012

Rituximab aids remission in idiopathic membranous nephropathy

Rituximab achieves good rates of remission in patients with persistent idiopathic membranous nephropathy, with few serious adverse events, study results show.

31 Jul 2012

Mapping rhomboid enzymes could eventually lead to drugs to treat malaria

Johns Hopkins scientists have decoded for the first time the "stability blueprint" of an enzyme that resides in a cell's membrane, mapping which parts of the enzyme are important for its shape and function.

31 Jul 2012

JHSPH dean expresses disappointment with USDA's retraction of Meatless Monday endorsement

On Friday, Michael J. Klag, MD, MPH, dean of the Johns Hopkins Bloomberg School of Public Health, wrote to U.S. Secretary of Agriculture Tom Vilsack to express his disappointment with USDA's recent retraction of Meatless Monday endorsement.

31 Jul 2012

Two new targets could enhance the body's defenses against West Nile and hepatitis C

Two new targets have been discovered for antiviral therapies and vaccines strategies that could enhance the body's defenses against such infectious diseases as West Nile and hepatitis C. The targets are within the infection warning system inside living cells.

31 Jul 2012

EPHA3 mutations may be important drivers of lung cancers

Vanderbilt-Ingram Cancer Center researchers have identified how one of the genes most commonly mutated in lung cancer may promote such tumors.

31 Jul 2012

New research indicates molecular signaling from end to end in peripheral nerve cells

When the longest cells in the body are injured at their farthest reaches, coordinating the cells' repair is no easy task. This is in part because these peripheral nerve cells can be extremely long - up to one meter in adult humans - which is a lot of distance for a molecular distress signal to cover in order to reach the "command center" of the cell's nucleus.

30 Jul 2012

Study sheds light on complexities of cancer genetics

30 Jul 2012

Bruker introduces high-resolution microscope for research in biological dynamics

At the Microscopy & Microanalysis (M&M) 2012 Annual Meeting, Bruker today announced the Dimension FastScan Bio™ Atomic Force Microscope (AFM), which enables high-resolution microscopy research in biological dynamics.

From Bruker Nano Surfaces and Metrology 30 Jul 2012

Antioxidants and pancreatic cancer risk: an interview with Dr Andrew Hart

The antioxidants that we mainly looked at were selenium, vitamin C and vitamin E. They are chemicals which inactivate pro-oxidants or free radicals. Smoking and normal metabolism can lead to the production of free radicals.

30 Jul 2012

Positive results from Vermillion OVA500 multi-center study for ovarian cancer

Vermillion, Inc., a leading molecular diagnostics company, today announced positive results from a new prospective, multi-center clinical study of its ovarian cancer diagnostic OVA1.

30 Jul 2012

Advaxis reports continued positive patient survival pattern in ADXS-HPV Phase 2 cervical cancer trial

Advaxis, Inc.,, a leader in developing the next generation of immunotherapies for cancer and infectious diseases, presented updated preliminary data from an ongoing randomized Phase 2 trial of ADXS-HPV being conducted in India in women with recurrent/refractory cervical cancer who have failed previous cytotoxic therapy.

30 Jul 2012

UTMB researchers receives NIH grant to develop engineered lung tissue for biomedical studies

University of Texas Medical Branch at Galveston researchers have been awarded a two-year, $1.25 million National Institutes of Health grant to develop a method of custom-growing human lung tissue to make a three-dimensional model for biomedical studies.

30 Jul 2012

Arena transfers BELVIQ NDA to Eisai

Eisai Inc. and Arena Pharmaceuticals, Inc. announced today that Arena has transferred the BELVIQ (lorcaserin hydrochloride) New Drug Application (NDA) to Eisai.

30 Jul 2012

New compound effective at blocking damage to the retina in diabetic retinopathy

Researchers at the University of Michigan Kellogg Eye Center have identified a compound that could interrupt the chain of events that cause damage to the retina in diabetic retinopathy. The finding is significant because it could lead to a novel therapy that targets two mechanisms at the root of the disease: inflammation and the weakening of the blood barrier that protects the retina.

30 Jul 2012

Fruit flies help pinpoint genetic changes that spell cancer

By studying fruit flies, scientists at A*STAR's Institute of Molecular and Cell Biology (IMCB) have successfully devised a fast and cost-saving way to uncover genetic changes that have a higher potential to cause cancer. With this new approach, researchers will now be able to rapidly distinguish the range of genetic changes that are causally linked to cancer (i.e. "driver" mutations) versus those with limited impact on cancer progression.

30 Jul 2012

OX40 molecule responsible for airway inflammation in the lungs

A research team led by Xian Chang Li, MD, PhD, Brigham and Women's Hospital (BWH) Transplantation Research Center, has shed light on how a population of lymphocytes, called CD4+ T cells, mature into various subsets of adult T helper cells.

30 Jul 2012

Researchers discover gene mutations in patients with alternating hemiplegia of childhood

Alternating hemiplegia of childhood (AHC) is a very rare disorder that causes paralysis that freezes one side of the body and then the other in devastating bouts that arise at unpredictable intervals. Seizures, learning disabilities and difficulty walking are common among patients with this diagnosis.

30 Jul 2012

Researchers isolate elusive human gene that causes NMNAT1-related Leber congenital amaurosis

Researchers from the Massachusetts Eye and Ear Infirmary, The Children's Hospital of Philadelphia, Loyola University Chicago Health Sciences Division and their collaborators have isolated an elusive human gene that causes a common form of Leber congenital amaurosis (LCA), a relatively rare but devastating form of early-onset blindness. The new LCA gene is called NMNAT1.

30 Jul 2012

Protein News and Research

Further Reading

FibroGen receives FDA Orphan Drug Designation for FG-3019 to treat IPF

Latrepirdine appears effective in treating Alzheimer's disease in animals

Rituximab aids remission in idiopathic membranous nephropathy

Mapping rhomboid enzymes could eventually lead to drugs to treat malaria

JHSPH dean expresses disappointment with USDA's retraction of Meatless Monday endorsement

Two new targets could enhance the body's defenses against West Nile and hepatitis C

EPHA3 mutations may be important drivers of lung cancers

New research indicates molecular signaling from end to end in peripheral nerve cells

Study sheds light on complexities of cancer genetics

Bruker introduces high-resolution microscope for research in biological dynamics

Antioxidants and pancreatic cancer risk: an interview with Dr Andrew Hart

Positive results from Vermillion OVA500 multi-center study for ovarian cancer

Advaxis reports continued positive patient survival pattern in ADXS-HPV Phase 2 cervical cancer trial

UTMB researchers receives NIH grant to develop engineered lung tissue for biomedical studies

Arena transfers BELVIQ NDA to Eisai

New compound effective at blocking damage to the retina in diabetic retinopathy

Fruit flies help pinpoint genetic changes that spell cancer

OX40 molecule responsible for airway inflammation in the lungs

Researchers discover gene mutations in patients with alternating hemiplegia of childhood

Researchers isolate elusive human gene that causes NMNAT1-related Leber congenital amaurosis

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