Immune Response News and Research

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Novel spike NTD mutations in SARS-CoV-2 Delta variant associated with increased viral loads and immune evasion

Researchers from the University of Southern California investigated mutations in the N-terminal and RBD domains of the spike protein.

20 Sep 2021

First dose of COVID-19 mRNA vaccine (BNT162b2) reduced platelet polyP levels in young females

In a recent study, scientists have tested the hypothesis that indicates the role of polyP in the COVID-19 mRNA vaccine-induced immune responses.

20 Sep 2021

COVID-19 vaccine-related allergies are rare, typically mild and treatable, finds study

Allergic reactions to the new mRNA-based COVID-19 vaccines are rare, typically mild and treatable, and they should not deter people from becoming vaccinated, according to research from the Stanford University School of Medicine.

20 Sep 2021

New discovery reveals how immune 'sentinel' cells are maintained

WEHI researchers have made a surprise discovery about how immune 'sentinel' cells are maintained, which could have implications for drugs in development for treating cancer.

20 Sep 2021

Research on SARS-CoV-2 and dendritic cells may explain why virus is so virulent

In a recent study released on the bioRxiv* preprint server, the researchers suggest that an aberrant inflammatory reaction associated with COVID-19 could be a result of escape from direct sensing by toll-like receptors (TLRs). Moreover, the researchers indicate that this phenomenon might underlie the lack of efficient immunity to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) early during infection.

20 Sep 2021

The influence of prior seasonal coronavirus infection on disease severity in COVID-19

A new study posted to the bioRxiv* server attempted to explore anti-spike IgG responses, Fc-gamma receptor (FcγR) activation, IgG targeting of immunodominant regions, and recall responses due to seasonal hCoV infections in non-hospitalized COVID-19 patients.

20 Sep 2021

A new synthetic multiantigen MVA vaccine COH04S1 effective against SARS-CoV-2

A new study utilized MVA to develop vaccine candidates that were subsequently evaluated in animal models of congenital cytomegalovirus disease.

19 Sep 2021

Study shows efficacy of mRNA vaccines against SARS-CoV-2 in individuals with obesity

A new study evaluated the antibody response against SARS-CoV-2 between individuals who were affected by abdominal obesity (AO) and those who were not,

19 Sep 2021

Specially designed lipid nanoparticles overcome resistance to anti-tumor immunotherapy

A specially designed lipid nanoparticle could deliver immune-signaling molecules into liver macrophage cells to overcome resistance to anti-tumor immunotherapy.

18 Sep 2021

R37 MERIT Award supports innovative ovarian cancer research

One of the most impactful advancements during the past decade in treating ovarian cancer is the use of PARP inhibitors (short for poly adenosine diphosphate-ribose polymerase). PARP inhibitors are a type of cancer drug that blocks the PARP enzyme from helping to repair DNA damage in cancer cells.

18 Sep 2021

Third dose of Pfizer-BioNTech vaccine increases neutralizing antibody levels against SARS-CoV-2

A third dose of the Pfizer-BioNTech vaccine significantly increased neutralizing antibody levels against SARS-CoV-2, the virus that causes COVID-19, according to new research published in the New England Journal of Medicine.

18 Sep 2021

A 100% French nasal vaccine against SARS-CoV-2 to move into the clinical phase in 2022

In contrast to intramuscular vaccines, only nasal vaccines are able to block the virus in the nose by inducing local immunity in the nasal mucosa, i.e. the portal of entry and multiplication of the virus.

18 Sep 2021

UW Medicine enrolls volunteers for COVID-19 booster vaccine trial

Researchers at the University of Washington School of Medicine are enrolling volunteers for a COVID-19 booster vaccine trial.

18 Sep 2021

Scientists identify new approach to overcome resistance to cancer immunotherapy

Hokkaido University scientists and colleagues in Japan have found a way that could help some patients overcome resistance to immunotherapy treatment for cancer. The approach, proven in mice experiments, was reported in the Journal for Immunotherapy of Cancer.

17 Sep 2021

Scientists examine kids’ unique immune systems as more fall victim to covid

Eighteen months into the covid-19 pandemic, with the delta variant fueling a massive resurgence of disease, many hospitals are hitting a heartbreaking new low. They're now losing babies to the coronavirus.

17 Sep 2021

Adenovirus-based nanoparticle vaccine elicits potent SARS-CoV-2 neutralizing antibody response

In a study available on the preprint server medRxiv*, researchers have created a vaccine designed to overcome issues associated with attenuated-virus vaccines.

17 Sep 2021

Multiple sclerosis patients elicit robust T-cell responses to mRNA COVID-19 vaccines

New research shows that Multiple Sclerosis (MS) patients undergoing anti-CD20 (aCD20) treatment – which depletes the B cells that contribute to the MS attacks – are able to mount robust T-cell responses to the mRNA COVID-19 vaccines, despite having a muted antibody response to the vaccines.

17 Sep 2021

Skin cancer patients could have better prognosis with stronger T cell receptor signal strength

New research led by the University of Birmingham suggests that skin cancer patients could have a better prognosis if their T cells send messages from five specific genes in their immune response to drugs given to treat the disease.

17 Sep 2021

Discovery of biological response platform could provide opportunity to alleviate allergic inflammation

New discoveries about a built-in rapid reaction system that triggers inflammatory responses when people are exposed to allergens, such as insects, mites, and fungi, also may hold the keys to helping more people manage their allergies in years to come.

17 Sep 2021

Three doses of inactivated BBIBP-CorV SARS-CoV-2 vaccine induce robust B and T cell responses

To investigate the immune memory sustainability of SARS-CoV-2-specific B cells and T cells, stimulated by the inactivated vaccine, and the potential need for a third booster dose in healthcare workers (HCWs), a non-randomized trial was undertaken by researchers at Sun Yat-sen University in Guangzhou, China. the research is posted online on the medRxiv* preprint server.

17 Sep 2021

Immune Response News and Research

Novel spike NTD mutations in SARS-CoV-2 Delta variant associated with increased viral loads and immune evasion

First dose of COVID-19 mRNA vaccine (BNT162b2) reduced platelet polyP levels in young females

COVID-19 vaccine-related allergies are rare, typically mild and treatable, finds study

New discovery reveals how immune 'sentinel' cells are maintained

Research on SARS-CoV-2 and dendritic cells may explain why virus is so virulent

The influence of prior seasonal coronavirus infection on disease severity in COVID-19

A new synthetic multiantigen MVA vaccine COH04S1 effective against SARS-CoV-2

Study shows efficacy of mRNA vaccines against SARS-CoV-2 in individuals with obesity

Specially designed lipid nanoparticles overcome resistance to anti-tumor immunotherapy

R37 MERIT Award supports innovative ovarian cancer research

Third dose of Pfizer-BioNTech vaccine increases neutralizing antibody levels against SARS-CoV-2

A 100% French nasal vaccine against SARS-CoV-2 to move into the clinical phase in 2022

UW Medicine enrolls volunteers for COVID-19 booster vaccine trial

Scientists identify new approach to overcome resistance to cancer immunotherapy

Scientists examine kids’ unique immune systems as more fall victim to covid

Adenovirus-based nanoparticle vaccine elicits potent SARS-CoV-2 neutralizing antibody response

Multiple sclerosis patients elicit robust T-cell responses to mRNA COVID-19 vaccines

Skin cancer patients could have better prognosis with stronger T cell receptor signal strength

Discovery of biological response platform could provide opportunity to alleviate allergic inflammation

Three doses of inactivated BBIBP-CorV SARS-CoV-2 vaccine induce robust B and T cell responses

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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