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New research may help develop drug for celiac disease

Celiac disease patients suffer from gluten intolerance and must adjust to a life without gluten from food sources like wheat, rye and barley.

20 Nov 2014

Type 3 interferons and T helper 2 cells: an interview with Grant Gallagher, Managing Director, HUMIGEN

The type 3 interferons - usually called the “lambda” interferons, or “IFNL” - are the most recently identified IFNs. We (myself and Sergei Kotenko) originally identified the receptor and then the three ligands (IFNL1,2,3; very recently a fourth, IFNL4, was discovered); the key paper was published in 2003.

18 Nov 2014

Common antimicrobial in household items causes liver fibrosis, cancer in mice

Triclosan is an antimicrobial commonly found in soaps, shampoos, toothpastes and many other household items. Despite its widespread use, researchers at University of California, San Diego School of Medicine report potentially serious consequences of long-term exposure to the chemical.

18 Nov 2014

UT Southwestern researchers identify new gene mutations involved in certain kidney cancers

Using next generation gene sequencing techniques, cancer researchers at UT Southwestern Medical Center have identified more than 3,000 new mutations involved in certain kidney cancers, findings that help explain the diversity of cancer behaviors.

17 Nov 2014

Preterm birth becomes world's number one killer of young children

For the first time in history, the complications of preterm birth outrank all other causes as the world's number one killer of young children.

17 Nov 2014

Researchers use cutting-edge software to predict aggressive breast cancer tumours

Researchers at Western University are using cutting-edge genetic mutation-analysis software developed in their lab to interpret mutations in tumour genome that may provide insight into determining which breast cancer tumours are more likely spread to other parts of the body and which ones won't.

17 Nov 2014

Cholesterol-fighting statins inhibit uterine fibroid tumors that account for 50% of hysterectomies

Researchers at the University of Texas Medical Branch at Galveston, in collaboration with The University of Texas Health Science Center at Houston (UTHealth), Baylor College of Medicine and the Georgia Regents University, report for the first time that the cholesterol-lowering drug simvastatin inhibits the growth of human uterine fibroid tumors.

16 Nov 2014

Research shows mustard and garlic receptor is linked to cold-induced pain

Some people experience cold not only as feeling cold, but actually as a painful sensation. This applies even to fairly mild temperatures - anything below 20°C.

14 Nov 2014

USC researcher receives first Broad Fellowship to study kidney stem cells

What makes stem cells develop into kidneys? Lori O'Brien, a postdoctoral research associate in the laboratory of Andy McMahon, has received the first Broad Fellowship to help answer this question.

12 Nov 2014

Funding makes next-generation scientific equipment available to CBC research community

The Chicago Biomedical Consortium is announcing a $3 million Infrastructure Initiative to promote investment in high-impact, next-generation scientific equipment at its member universities. The Initiative aims to make modern and powerful tools available to the CBC research community at a time when federal grants for scientific infrastructure are scarce.

12 Nov 2014

New findings could help develop therapeutic options for glycogen storage disease

Glycogen storage disorders, which affect the body's ability to process sugar and store energy, are rare metabolic conditions that frequently manifest in the first years of life. Often accompanied by liver and muscle disease, this inability to process and store glucose can have many different causes, and can be difficult to diagnose.

11 Nov 2014

Stopping the death of synapses: an interview with Dr Soledad Galli

Synapses are the sites that connect neurons – sites where information is passed from one neuron to another. They are highly specialized structures and synaptic function is crucial for normal brain function.

11 Nov 2014

Researchers refine diagnostic tools to predict treatment outcomes for children with neuroblastoma

Oncology researchers studying gene mutations in the childhood cancer neuroblastoma are refining their diagnostic tools to predict which patients are more likely to respond to drugs called ALK inhibitors that target such mutations. Removing some of the guesswork in diagnosis and treatment, the researchers say, may lead to more successful outcomes for children with this often-deadly cancer.

11 Nov 2014

New vaccination approach can reduce tumor burden, suppress formation of lung metastases

In a new study published in the scientific journal Oncotarget researchers from Uppsala University show that a therapeutic vaccine directed against tumor vessels can reduce tumor burden and suppress formation of spontaneous lung metastases in a mouse model for metastatic breast cancer.

9 Nov 2014

Researchers obtain detailed picture of how Gas5 RNA interacts with steroid hormone receptors

It arises from what scientists previously described as "junk DNA" or "the dark matter of the genome," but this gene is definitely not junk.

7 Nov 2014

IU School of Medicine researchers identify new protein that can control diabetes

Indiana University School of Medicine researchers have identified a small protein with a big role in lowering plasma glucose and increasing insulin sensitivity.

6 Nov 2014

Effects of unhealthy lifestyle persist even after atherosclerosis treatment

Almost everyone knows that improving your eating habits will most likely improve your health. What most people may not know, however, is that the effects of poor eating habits persist long after dietary habits are improved. In a new report appearing in the November 2014 issue of the Journal of Leukocyte Biology, scientists use mice to show that even after successful treatment of atherosclerosis (including lowering of blood cholesterol and a change in dietary habits) the effects of an unhealthy lifestyle still affect the way the immune system functions.

6 Nov 2014

3D brain-like tissue: an interview with Professor David Kaplan, Tufts University

In 2D, neurons tend to form limited connectivity reflective of the 3D complexity in the brain and have more limited cultivation time before reduction in functions.

4 Nov 2014

Researchers to develop new tests to evaluate cognitive growth in people with intellectual disability

Leading researchers, funded through a new, five-year, $3.2 million grant from the National Institutes of Health, are collaborating to develop and evaluate tests designed to measure and track changes in the cognitive functioning of people who typically are difficult to assess accurately: those with an intellectual disability, formerly termed mental retardation.

3 Nov 2014

Sleep-wake cycles are genetically connected to the bladder

If you think sleep problems and bladder problems are a fact of life in old age, you may be right. A new report appearing in the November 2014 issue of The FASEB Journal, shows that our sleep-wake cycles are genetically connected to our bladder, and disruptions to one may cause problems with the other.

31 Oct 2014

Biochemistry News and Research

New research may help develop drug for celiac disease

Type 3 interferons and T helper 2 cells: an interview with Grant Gallagher, Managing Director, HUMIGEN

Common antimicrobial in household items causes liver fibrosis, cancer in mice

UT Southwestern researchers identify new gene mutations involved in certain kidney cancers

Preterm birth becomes world's number one killer of young children

Researchers use cutting-edge software to predict aggressive breast cancer tumours

Cholesterol-fighting statins inhibit uterine fibroid tumors that account for 50% of hysterectomies

Research shows mustard and garlic receptor is linked to cold-induced pain

USC researcher receives first Broad Fellowship to study kidney stem cells

Funding makes next-generation scientific equipment available to CBC research community

New findings could help develop therapeutic options for glycogen storage disease

Stopping the death of synapses: an interview with Dr Soledad Galli

Researchers refine diagnostic tools to predict treatment outcomes for children with neuroblastoma

New vaccination approach can reduce tumor burden, suppress formation of lung metastases

Researchers obtain detailed picture of how Gas5 RNA interacts with steroid hormone receptors

IU School of Medicine researchers identify new protein that can control diabetes

Effects of unhealthy lifestyle persist even after atherosclerosis treatment

3D brain-like tissue: an interview with Professor David Kaplan, Tufts University

Researchers to develop new tests to evaluate cognitive growth in people with intellectual disability

Sleep-wake cycles are genetically connected to the bladder

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