Laboratory News and Research

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Estrogen protects male rats from aortic aneurysms

When it comes to abdominal aortic aneurysms – life-threatening bulges or weak areas in the main artery feeding blood to the lower half of the body – new U-M research shows that it is definitely better to be female.

12 Oct 2004

Dietary iron imbalances increase the odds of developing Parkinson's disease

You might want to toss those iron-fortified vitamins, because absent a diagnosed deficiency too much of a good thing can be bad.

12 Oct 2004

New research points to potential new treatments for sickle cell disease

New research from the University of North Carolina at Chapel Hill reveals why red blood cells from people with sickle cell disease are stickier than healthy red cells, pointing the way to potential new treatments for sickle cell disease.

12 Oct 2004

New study offers rare glimpse of how the smallpox virus attacks its victims

Results of a new study in monkeys offer scientists a rare glimpse of how, on a molecular level, the smallpox virus attacks its victims. The findings shed light on how the virus caused mass death and suffering, and will help point the way to new diagnostics, vaccines and drugs that would be needed in the event of a smallpox bioterror incident.

12 Oct 2004

A change in the national polio vaccination policy has led to the elimination of vaccine-associated paralytic poliomyelitis

The researchers found that from 1990 through 1999, 61 cases of paralytic polio were reported; 59 (97 percent) of these were VAPP (1 case per 2.9 million OPV doses distributed), 1 case was imported, and 1 case was indeterminate.

12 Oct 2004

A unique new non-invasive technique for high resolution optical imaging of the eye

The technique, pioneered by the University of Kent, is funded by the Toronto-based company, Ophthalmic Technology Inc (OTI). The University’s Applied Optics Group is currently working with university hospitals in New York (USA), Osaka (Japan), Asahikawa (Japan), Amsterdam (Netherlands) and Milan (Italy) to carry out preliminary clinical trials.

12 Oct 2004

Researchers identify common mutation in T-cell acute lymphocytic leukemia

Researchers at Brigham and Women’s Hospital (BWH) and Dana-Farber Cancer Institute (DFCI) have made a breakthrough discovery, identifying a common mutation in T-cell acute lymphocytic leukemia (T-ALL), an important form of cancer in children and adolescents.

11 Oct 2004

Desert knowledge identifies plants with market potential

Indigenous Australian's from desert communities are being encouraged to use their traditional knowledge of native plants to identify, grow and market plants for use as food, medicine and other products for their long-term livelihood.

11 Oct 2004

Study sheds light on events orchestrating the changes when mammalian eggs are fertilized and become embryos

A new study sheds light on events orchestrating the changes when mammalian eggs are fertilized and become embryos. Researchers have discovered that expression of genes in mouse eggs and very early embryos is activated in part by regions of DNA called retrotransposons, which may have originated from retroviruses.

11 Oct 2004

Signaling pathway could be a valuable target for future drug therapies against systemic lupus erythematosus

Medical investigators at the Hospital for Special Surgery have identified an important new signaling pathway they believe could be a valuable target for scientists to aim at with future drug therapies that might one day reverse diseases such as systemic lupus erythematosus, according to a recent article published in “Nature Immunology.”

11 Oct 2004

Black women are three times more likely than white women to die during pregnancy

Black women are three times more likely than white women to die during pregnancy, and twice as many black babies as white babies die in infancy. Yet researchers know little about why pregnancy and infant health differ by race, despite massive efforts to address this persistent problem.

10 Oct 2004

Studies reveal complex molecular choreography with implications for human health and disease

As interactions of cellular proteins increasingly take center stage in basic biomedical research, studies are revealing a complex molecular choreography with implications for human health and disease.

10 Oct 2004

Repeated re-testing of women with a history of chlamydia is a cost-effective strategy for preserving reproductive health

Researchers from the Harvard School of Public Health assessed the cost-effectiveness and clinical benefits of currently existing guidelines and new, proposed guidelines for screening women for chlamydia.

8 Oct 2004

New targets for combating infections in medical implants

Navarre researcher, Jaione Valle Turrillas, has identified two genes that could help as targets for pharmaceutical drugs that fight the Staphylococcus aureus bacteria - one of the bacteria which causes most infections in medical implants.

8 Oct 2004

First use of technology called ubiquitin-mediated fluorescence complementation to study a cell-signaling mechanism called ubiquitination

Researchers at the University of Michigan Medical School and Howard Hughes Medical Institute have found a way to see proteins in cells that have been tagged by a molecular “sticky note” called ubiquitin.

8 Oct 2004

Researchers discover mechanism that may help to explain how angiogenesis inhibitors work on normal, blood vessel-forming endothelial cells

Northwestern University researchers have discovered a mechanism that may help to explain how angiogenesis inhibitors work on normal, blood vessel-forming endothelial cells, but not on insidious, aggressive melanoma cells that masquerade as endothelial-like cells by forming their own vascular networks, called "vasculogenic mimicry."

8 Oct 2004

Researchers have created a theoretical model that may shed light on a brain science mystery

A research team based at Brown University has created a theoretical model that may shed light on a brain science mystery: What happens to cells when humans learn and remember?

7 Oct 2004

Britain's Chief Medical Officer has announced new measures to tackle and eliminate tuberculosis in Britain

The Plan, Stopping Tuberculosis in England, provides a strong commitment to tackle the disease by increasing the awareness of the disease amongst health professional and the public, establishing high quality surveillance to monitor the disease concentrating on high risk groups, identifying the infection early, and ensuring excellence in clinical care for patients with TB.

7 Oct 2004

Short-term exercise has a significant impact on insulin action in overweight people

Carefully controlling the amount of food and drink that formerly sedentary, overweight people ingest during and after short-term exercise has a significant impact on insulin action.

7 Oct 2004

In a world first, scientists have successfully grown square bacteria in the lab

In a world first, Australian scientists have successfully grown an unusual square-shaped bacterium found in salt lakes that has mystified scientists for a quarter of a century.

7 Oct 2004

Laboratory News and Research

Estrogen protects male rats from aortic aneurysms

Dietary iron imbalances increase the odds of developing Parkinson's disease

New research points to potential new treatments for sickle cell disease

New study offers rare glimpse of how the smallpox virus attacks its victims

A change in the national polio vaccination policy has led to the elimination of vaccine-associated paralytic poliomyelitis

A unique new non-invasive technique for high resolution optical imaging of the eye

Researchers identify common mutation in T-cell acute lymphocytic leukemia

Desert knowledge identifies plants with market potential

Study sheds light on events orchestrating the changes when mammalian eggs are fertilized and become embryos

Signaling pathway could be a valuable target for future drug therapies against systemic lupus erythematosus

Black women are three times more likely than white women to die during pregnancy

Studies reveal complex molecular choreography with implications for human health and disease

Repeated re-testing of women with a history of chlamydia is a cost-effective strategy for preserving reproductive health

New targets for combating infections in medical implants

First use of technology called ubiquitin-mediated fluorescence complementation to study a cell-signaling mechanism called ubiquitination

Researchers discover mechanism that may help to explain how angiogenesis inhibitors work on normal, blood vessel-forming endothelial cells

Researchers have created a theoretical model that may shed light on a brain science mystery

Britain's Chief Medical Officer has announced new measures to tackle and eliminate tuberculosis in Britain

Short-term exercise has a significant impact on insulin action in overweight people

In a world first, scientists have successfully grown square bacteria in the lab

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