Fentanyl News and Research

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Fentanyl is a powerful synthetic opiate analgesic similar to but more potent than morphine. It is typically used to treat patients with severe pain, or to manage pain after surgery. It is also sometimes used to treat people with chronic pain who are physically tolerant to opiates. It is a schedule II prescription drug.

Apparent drug overdose spike in 2025 driven by flawed modeling

Last June, several mainstream media outlets reported a surge in U.S. drug overdose deaths in early 2025 that was based on data from the U.S. Centers for Disease Control and Prevention (CDC).

8 Apr 2026

Highly potent opioid shows potential as therapy for pain and opioid use disorder

Researchers at the National Institutes of Health (NIH) have identified a novel, highly potent opioid that shows potential as a therapy for both pain and opioid use disorder.

1 Apr 2026

Maker of device to treat addiction withdrawal seeks counties’ opioid settlement cash

In the early 2000s, Michelle Warfield worked at a factory, hauling heavy seats for Ford trucks on and off an assembly line. To suppress daily aches in her back and hips, her doctor prescribed opioid painkillers.

18 Mar 2026

Study links smokable drug use to heightened incidence of severe burns

A new analysis in Oregon reveals a heightened incidence of severe burns requiring hospital-level care as illicit drug use has shifted nationwide from injection to smoking.

16 Mar 2026

New release Wiley's Mass Spectra of Designer Drugs 2026 expands coverage of emerging novel psychoactive substances

Wiley, a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation and learning, today announced the 2026 release of Mass Spectra of Designer Drugs, the essential GC‑MS spectral database used by forensic laboratories worldwide for the rapid identification of illicit substances.

From John Wiley and Sons - Scientific Publishers 16 Mar 2026

Tropical cyclones linked to rise in drug-related deaths months after landfall

Tropical cyclones, including hurricanes and tropical storms, are linked to increased rates of drug-related deaths up to three months after the storm passes-particularly in higher-income, White communities and among younger populations.

20 Feb 2026

Addiction consults improve care for drug-related eye infections

Eric Gaier, MD, PhD, and Dean Eliott, MD, of the Department of Ophthalmology at Mass Eye and Ear, a member of the Mass General Brigham healthcare system, are co-authors of a paper published in Ophthalmology Retina, "Substance Use Disorder Interventions and Ophthalmic Outcomes for Injection Drug Use-Associated Endogenous Endophthalmitis."

10 Feb 2026

Foreign legislation strongly influences domestic novel psychoactive substance deaths

Ric Treble is a retired forensic chemist, who has studied the development of novel drugs for over thirty years.

30 Jan 2026

Bradycardia emerges as key clinical sign of xylazine-opioid overdose

Researchers have identified bradycardia-an abnormally low heart rate–as a symptom of xylazine-opioid overdose.

14 Jan 2026

Thrift store. Clinic. Roller rink. Center becomes ‘radical’ lifeline amid homelessness, drug crises.

From the outside, the abandoned Family Dollar store in the Lower 9th Ward looks intimidating. It's covered in graffiti, with aluminum cans and trash dotting the parking lot.

9 Jan 2026

Inside the battle for the future of addiction medicine

Elyse Stevens had a reputation for taking on complex medical cases. People who'd been battling addiction for decades. Chronic-pain patients on high doses of opioids. Sex workers and people living on the street.

7 Jan 2026

Washington’s homeless hide in plain sight, growing sicker and costing taxpayers more

Every night, Abdullah Ibrahim retreats from the streets into a wooded stretch along the Potomac River.

18 Dec 2025

Flow chemistry, AI, and NMR: A next-gen approach to scalable API production

Discover how AI, flow chemistry, and NMR come together in the PiPAC project to revolutionize scalable and autonomous API production.

From Bruker BioSpin Division 17 Dec 2025

Most Medicaid patients do not receive life-saving drugs for opioid use disorder

A US study of more than a million Medicaid enrollees, newly diagnosed with opioid use disorder (OUD), finds most – nearly seven in 10 – are not receiving access to potentially life-saving drugs within six months.

24 Nov 2025

Take-home methadone provides a lifesaving bridge to recovery after hospitalization

For patients recovering from opioid use disorder, particularly from drugs like fentanyl or heroin, the days immediately following a hospital stay are among the most dangerous.

22 Nov 2025

Year-long adherence to buprenorphine sharply reduces overdose risk in young people

New research from Mass General Brigham finds that adolescents and young adults who stayed on the medication buprenorphine for at least a year had markedly lower risks of opioid overdose and hospitalization compared with peers who discontinued medication early or took it inconsistently.

18 Nov 2025

Opioid receptors caught in motion offering clues for safer painkillers

Scientists have known for decades that opioids relieve pain by binding to molecular switches in the brain called mu-opioid (pronounced "mew-opioid") receptors. What they didn't know - until now - was exactly what happens next.

5 Nov 2025

Study highlights need to establish clinical practice guidelines for surgical patients receiving MOUDs

In an effort to stem the death toll from opioid overdose, United States public health officials have promoted the prescription and use of medications like buprenorphine that blunt the effects of illicit opioids such as fentanyl.

27 Oct 2025

Intraoperative music therapy reduces anesthetic use and physiological stress

A groundbreaking study published in the peer-reviewed journal Music and Medicine demonstrates that intraoperative music therapy significantly reduces the amount of propofol and fentanyl required during laparoscopic cholecystectomy performed under general anesthesia.