Heart Failure News and Research

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Heart failure (HF) is a condition in which a problem with the structure or function of the heart impairs its ability to supply sufficient blood flow to meet the body's needs. It should not be confused with cardiac arrest or myocardial infarction.

Blocking a naturally occurring molecule reverses deadly lung disease in preclinical models

Researchers blocked a naturally occurring molecule to reverse pulmonary arterial hypertension in preclinical models, a finding that could point to a new treatment approach for people with a rare and often fatal lung disease.

2 Sep 2026

Scientists develop lab-grown heart tissue model for heart failure

Scientists study the underlying causes of a disease or test new potential drugs in animal models or cells obtained from human biopsy specimens before clinical trials.

2 Sep 2026

Mizzou researchers explore first drug treatment for aortic valve calcification

University of Missouri researchers are advancing a promising new approach to treating a serious heart condition that affects millions of older adults worldwide.

1 Sep 2026

Semaglutide did more than cut weight in this analysis of 6,239 adults

A systematic review and meta-analysis of nine randomized controlled trials involving 6,239 adults with overweight or obesity without diabetes found that subcutaneous semaglutide produced substantially greater reductions in body weight, waist circumference, and C-reactive protein than placebo. The higher dose of 7.2 mg semaglutide showed potential for greater weight loss, although the evidence is largely based on a single trial and requires confirmation.

31 Aug 2026

Routine referral of prostate cancer patients to a cardiovascular specialist fails to cut cardiac events

Men with prostate cancer have a high risk of heart disease, especially when treated with hormone therapy.

31 Aug 2026

New tool predicts heart failure treatment effects on blood pressure, kidney function and serum potassium

A new heart failure (HF) treatment effect calculator could help overcome one of the largest barriers to effective heart failure care by predicting the expected effects of treatment on blood pressure, kidney function and potassium levels.

31 Aug 2026

Targeted lead placement fails to improve cardiac resynchronization outcomes

Targeted placement of the left ventricular lead did not improve outcomes in patients with heart failure undergoing cardiac resynchronization therapy, according to results presented in a Hot Line session today at ESC Congress 2026 and published simultaneously in The Lancet.

31 Aug 2026

Transcatheter tricuspid valve repair lowers mortality and hospitalizations in high-risk patients

Transcatheter tricuspid valve repair significantly improved clinical outcomes in high-risk patients with severe tricuspid regurgitation, according to results presented in a Hot Line session today at ESC Congress 2026 and published simultaneously in the New England Journal of Medicine.

31 Aug 2026

Nurse-led collaborative care significantly improves heart failure patient outcomes

Days alive and out of hospital were significantly increased in patients with heart failure when a nurse-coordinated collaborative care model was introduced, according to results presented in a Hot Line session today at ESC Congress 2026 and published simultaneously in Circulation.

31 Aug 2026

TAVI-first strategy proves noninferior to PCI-first approach in new trial

A TAVI-first strategy was noninferior to a PCI-first strategy after one years' follow-up, according to results presented in a Hot Line session today at ESC Congress 2026 and published simultaneously in the New England Journal of Medicine.

30 Aug 2026

Oral relaxin agonist AZD5462 improves cardiac function in heart failure patients

The oral relaxin agonist, AZD5462, improved cardiac function in patients with chronic heart failure, according to results presented in a Hot Line session today at ESC Congress 2026 and published simultaneously in Circulation.

30 Aug 2026

Met-HeFT trial finds no cardiovascular benefit from metformin

Metformin did not significantly affect the risk of cardiovascular outcomes in patients with heart failure with reduced ejection fraction and diabetes or at risk of diabetes.

30 Aug 2026

H-ISDN shows no significant benefit in broader heart failure population

In patients with heart failure, hydralazine with isosorbide dinitrate did not significantly improve the incidence of death or heart failure events and treatment discontinuation rates were high.

30 Aug 2026

Breast cancer survivors could avoid lifelong heart medication, research suggests

Many breast cancer survivors whose treatment caused them to develop problems with their heart function can safely stop their medication after their heart recovers and most won't need to continue treatment long-term, according to a study funded by the British Heart Foundation and presented at the European Society of Cardiology Congress in Munich.

30 Aug 2026

Digital registry strategy doubles heart failure treatment uptake

A registry-based digital strategy that identified untreated patients and invited them to a telephone consultation more than doubled implementation of an effective type of heart failure treatment.

29 Aug 2026

Trial shows antiplatelet therapy needs personalization after stent implantation

Antiplatelet monotherapy reduced bleeding but dual therapy provided greater cardiovascular event protection in patients at high ischemic risk who had undergone stent implantation 12 months earlier.

29 Aug 2026

Younger heart patients benefit from implantable cardioverter-defibrillators in CMR GUIDE trial

An implantable cardioverter-defibrillator did not improve the primary endpoint overall in the CMR GUIDE trial but younger patients appeared to benefit, according to results presented in a Hot Line session today at ESC Congress 2026 and published simultaneously in JAMA.

28 Aug 2026

Heart Failure News and Research

Further Reading

Blocking a naturally occurring molecule reverses deadly lung disease in preclinical models

Scientists develop lab-grown heart tissue model for heart failure

Mizzou researchers explore first drug treatment for aortic valve calcification

Semaglutide did more than cut weight in this analysis of 6,239 adults

Routine referral of prostate cancer patients to a cardiovascular specialist fails to cut cardiac events

New tool predicts heart failure treatment effects on blood pressure, kidney function and serum potassium

Targeted lead placement fails to improve cardiac resynchronization outcomes

Transcatheter tricuspid valve repair lowers mortality and hospitalizations in high-risk patients

Nurse-led collaborative care significantly improves heart failure patient outcomes

TAVI-first strategy proves noninferior to PCI-first approach in new trial

Oral relaxin agonist AZD5462 improves cardiac function in heart failure patients

Met-HeFT trial finds no cardiovascular benefit from metformin

H-ISDN shows no significant benefit in broader heart failure population

Breast cancer survivors could avoid lifelong heart medication, research suggests

Digital registry strategy doubles heart failure treatment uptake

Trial shows antiplatelet therapy needs personalization after stent implantation

Younger heart patients benefit from implantable cardioverter-defibrillators in CMR GUIDE trial

CARDIO-TTRansform trial investigating eplontersen fails to meet primary efficacy endpoint

New guidelines simplify heart failure phenotypes into two groups

New international guidelines highlight the extensive benefits of cardiac rehabilitation

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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