Hypertrophic Cardiomyopathy News and Research

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Hypertrophic cardiomyopathy is a condition that affects the heart’s ability to pump blood effectively due to the thickening (hypertrophy) of the heart muscle which becomes stiff as a result.

American College of Cardiology establishes a digital hypertrophic cardiomyopathy registry

The American College of Cardiology has established a digital hypertrophic cardiomyopathy (HCM) registry to learn more about one of the most common genetic cardiovascular diseases and provide more equitable access to treatment and care.

19 Aug 2025

New gene editing approach targets mutation behind common genetic heart disease

Fourteen million people worldwide suffer from enlarged hearts, or hypertrophic cardiomyopathy (HCM), a genetic disease that thickens the heart's walls, making it harder for the organ to pump blood - but many of them don't know it.

8 Jul 2025

AI model predicts death from sudden cardiac arrest with greater accuracy than doctors

A new AI model is much better than doctors at identifying patients likely to experience cardiac arrest.

2 Jul 2025

New PET/CT imaging technique enables early detection of multiple forms of cardiomyopathy

A new PET/CT imaging technique that visualizes activated fibroblasts in the heart muscle enables early detection of multiple forms of cardiomyopathy, according to research presented at the Society of Nuclear Medicine and Molecular Imaging 2025 Annual Meeting.

24 Jun 2025

Mount Sinai researchers enhance AI tool to better detect heart disease risk

Mount Sinai researchers studying a type of heart disease known as hypertrophic cardiomyopathy (HCM) have calibrated an artificial intelligence (AI) algorithm to quickly and more specifically identify patients with the condition and flag them as high risk for greater attention during doctor's appointments.

22 Apr 2025

Redefining cardiovascular medicine through the lens of sncRNAs

In a transformative review, small noncoding RNAs (sncRNAs) have emerged as pivotal regulators in the complex landscape of cardiovascular diseases.

20 Apr 2025

Defibrillators and CPR cut marathon cardiac deaths in half, study shows

Researchers found that while the rate of cardiac arrests during U.S. marathons and half-marathons remained stable from 2010 to 2023, the likelihood of death from these events dropped by nearly half—thanks to faster emergency response and widespread use of defibrillators.

31 Mar 2025

New guidelines allow select athletes with heart abnormalities to participate in competitive sports

Recent research suggests that select athletes with cardiovascular abnormalities may be able to safely participate in competitive sports after shared decision-making with their clinicians about potential risks, according to a joint scientific statement published today in the American Heart Association's flagship, peer-reviewed journal Circulation and simultaneously in JACC, the flagship journal of the American College of Cardiology.

21 Feb 2025

New study highlights gender differences in diagnosing heart condition

Women may be missing a diagnosis of a potentially deadly heart condition due to guidelines that don't account for natural differences in sex and body size, according to a new study led by UCL (University College London) researchers.

10 Jan 2025

Trametinib shows promise in treating severe hypertrophic cardiomyopathy in children

Trametinib, a mitogen-activated protein kinase (MEK) inhibitor, reduces mortality and morbidity in children with severe hypertrophic cardiomyopathy (HCM) caused by pathogenic variants in the RAS/MAPK pathway, according to a study published today in JACC: Basic to Translational Science.

8 Jan 2025

American Heart Association launches initiative to improve hypertrophic cardiomyopathy care

An estimated 1 in 500 people in the U.S. are living with hypertrophic cardiomyopathy (HCM) - the most common inherited heart disease - and many are unaware.

4 Dec 2024

Benefits of sport and leisure activities outweigh the risks for people with heart disease, cardiologists say

While exercise is generally beneficial for a person's overall health, physical activities may increase the risk of adverse cardiovascular disease events in certain susceptible individuals. However, cardiologists say that the benefits outweigh the risks.

19 Nov 2024

New guidelines for cardiovascular management in noncardiac surgery released

The 2024 guideline for cardiovascular management of adults undergoing noncardiac surgery reflects a decade of updates and new evidence since the guideline's last release in 2014.

24 Sep 2024

Expanding the TTN mutation spectrum for dilated cardiomyopathy diagnosis

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Dilated cardiomyopathy (DCM), a severe heart disease, is the leading cause of heart failure and sudden cardiac death worldwide.

19 Aug 2024

AI transforming cardiovascular care with groundbreaking diagnostic and prognostic innovations

AI tools are revolutionizing cardiovascular healthcare by enhancing diagnostics, prognostics, and biomarker detection, thus improving the precision and efficacy of care. The review also addresses the potential risks and challenges in integrating AI into clinical workflows.

25 Jun 2024

Beyond genes, new research explores mechanics and calcium signaling

Using animals to study heart disease doesn't always translate well to human health outcomes, and human heart cells available for research don't work outside the human body.

25 Jun 2024

Investigational drug shows promise in increasing oxygen uptake for patients with heart condition

People with a common heart condition were able to use significantly more oxygen while exercising after taking an investigational drug in an international clinical trial, according to a study published today in the New England Journal of Medicine.

14 May 2024

Aficamten shows promise in enhancing exercise capacity in patients with hypertrophic cardiomyopathy

Even though mortality and hospitalization rates have improved, the quality of life for those living with hypertrophic cardiomyopathy (HCM) can be compromised with limiting symptoms such as exertional dyspnoea and decreased exercise capacity.

13 May 2024

Semaglutide improves heart failure symptoms and reduces loop diuretic dose

Semaglutide reduces the need for loop diuretic use and dose, and has positive effects on symptoms, physical limitations, and body weight in patients with heart failure with preserved ejection fraction (HFpEF) regardless of diuretic use, according to late breaking research presented today at Heart Failure 2024, a scientific congress of the European Society of Cardiology.