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A dimensional reduction strategy for enhanced cryopreservation of red blood cells

Small amounts of nanometer-thin metal-organic layers efficiently protect red blood cells during freezing and thawing, as a team of researchers writing in the journal Angewandte Chemie has discovered. The nanolayers, made from metal-organic frameworks based on the metal hafnium, prevent ice crystal formation at very low concentrations. This effective novel cryoprotection mode could be used to develop new and more efficient cryoprotectants for the biosciences.

29 Apr 2023

Revolutionizing drug discovery: Giga-scale screening unleashes power of AI and virtual libraries

Research discusses recent advances in computer-aided drug discovery, including the use of virtual screening and deep learning methods and their potential to revolutionize the drug discovery process by identifying diverse, potent, and drug-like ligands to protein targets.

28 Apr 2023

Groundbreaking discovery could pave the way for safer and more effective blood thinners

Safer and more effective blood thinners could be on the way following a groundbreaking discovery by researchers at UBC and the University of Michigan, published today in Nature Communications.

26 Apr 2023

New approach to CAR T-cell therapy shows promise against small cell lung cancer in preclinical study

A new approach to chimeric antigen receptor T-cell (CAR T) therapy has shown great promise against small cell lung cancer (SCLC) in a preclinical study.

25 Apr 2023

The potential anti-cancer and antioxidant properties of walnuts

Researchers reviewed current literature to examine walnuts' potential antioxidant and anti-cancer properties.

25 Apr 2023

Researchers develop novel molecular nanocages for siRNA delivery

Small interfering RNAs (siRNAs) are novel therapeutics that can be used to treat a wide range of diseases.

19 Apr 2023

Lipid molecules enable uptake of therapies into the brain after a stroke

To get therapies into the brain after a stroke, researchers are increasingly making use of the blood–brain barrier, which allows only certain molecules to pass from the blood into the brain.

17 Apr 2023

VUMC-led trial demonstrates the inefficacy of two investigational drugs for treating severe COVID-19

Despite the success of vaccines for preventing COVID-19, and of drugs for treating the disease, outcomes for severely ill patients admitted to the hospital remains poor.

11 Apr 2023

Study finds human surfactant protein A can inhibit SARS-CoV-2 infectivity

Researchers assess the efficacy of the human surfactant protein A against SARS-CoV-2 infectivity.

10 Apr 2023

Immune checkpoint inhibitor treatment is facilitated by dietary tryptophan metabolite synthesized by Lactobacillus reuteri

Researchers highlight how dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment.

10 Apr 2023

Researchers construct super-sized nanocage for delivering larger drug cargoes

Think about how frustrating it is to try to fit a gift into a box that is too small. Sometimes you just need a bigger box.

6 Apr 2023

Exploring the gut microbiome's role in rheumatoid arthritis pathogenesis

Researchers analyzed data on the association between intestinal microbiome dysbiosis and rheumatoid arthritis.

6 Apr 2023

New treatment for fibrous dysplasia shows promising results in NIH clinical trial

A clinical trial at the National Institutes of Health found that a medication, denosumab, significantly reduced abnormal bone turnover in adults with fibrous dysplasia, a rare disease marked by weak and misshapen bones.

4 Apr 2023

Researchers develop a biosensor for real time detection of the G-protein molecular switch

DGIST (President: Kook Yang) announced on March 16th that the research team led by Professor Byung-Chang Suh has investigated for the first time the real-time effect of the G-protein cycle, which acts as a switch in our body, on the structural changes in G protein-coupled receptors (GPCRs).

31 Mar 2023

Ligand News and Research

A dimensional reduction strategy for enhanced cryopreservation of red blood cells

Revolutionizing drug discovery: Giga-scale screening unleashes power of AI and virtual libraries

Groundbreaking discovery could pave the way for safer and more effective blood thinners

New approach to CAR T-cell therapy shows promise against small cell lung cancer in preclinical study

The potential anti-cancer and antioxidant properties of walnuts

Researchers develop novel molecular nanocages for siRNA delivery

Lipid molecules enable uptake of therapies into the brain after a stroke

VUMC-led trial demonstrates the inefficacy of two investigational drugs for treating severe COVID-19

Study finds human surfactant protein A can inhibit SARS-CoV-2 infectivity

Immune checkpoint inhibitor treatment is facilitated by dietary tryptophan metabolite synthesized by Lactobacillus reuteri

Researchers construct super-sized nanocage for delivering larger drug cargoes

Exploring the gut microbiome's role in rheumatoid arthritis pathogenesis

New treatment for fibrous dysplasia shows promising results in NIH clinical trial

Researchers develop a biosensor for real time detection of the G-protein molecular switch

Study indicates interleukin-6-dependant pathway dysregulation as a key druggable feature of COVID-19

Synthetic hydrogel-based lymphoma tumor model paves way for personalized cancer therapies

Study may pave way for a more nuanced understanding of taste perception

Elevated mucosal immune response expedites COVID-19 recovery

Hyperinflammation triggers long COVID headaches

Bitter taste receptors are a potential target for treating asthma or COPD

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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