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Research unravels molecular mechanisms of antisense oligonucleotides

Stanley T. Crooke, MD, PhD, CEO of Ionis Pharmaceuticals and recipient of the 2016 Lifetime Achievement Award from the Oligonucleotide Therapeutic Society presents a detailed look at the mechanisms that underlie antisense drug activity in the article entitled "Molecular Mechanisms of Antisense Oligonucleotides," published in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc. publishers.

2 Feb 2017

UW-Madison scientists discover bone marrow proteins that regulate bone-building cells

The prospect of regenerating bone lost to cancer or trauma is a step closer to the clinic as University of Wisconsin-Madison scientists have identified two proteins found in bone marrow as key regulators of the master cells responsible for making new bone.

2 Feb 2017

Virulence of bacterial infections dependent on presence of cytotoxins, study reports

Beginning in the mid-1980s, an epidemic of severe invasive infections caused by Streptococcus pyogenes (S. pyogenes), also known as group A streptococcus (GAS), occurred in the United States, Europe, and elsewhere.

2 Feb 2017

Researchers identify new mechanism that protects from bacterial infections

An international team led by the University if Barcelona has identified a new antibacterial mechanism that protects macrophages - defense cells in the immune system- from the infection of the bacteria Salmonella enterica serovar Typhimurium, a pathogen associated with several gastrointestinal diseases.

2 Feb 2017

Nicotine creates cascade of effects in the brain that get worse over time

The first period of nicotine abstinence proceeded as expected. The surprise came after three months when the lab rats suddenly became fearless and sought out well-lighted areas that prey animals normally avoid. At the same time, signaling in the brain's reward system changed, as shown by a study at Sahlgrenska Academy.

2 Feb 2017

Launch of next-generation Optima AUC advances protein research and macromolecule characterization

Beckman Coulter returns analytical ultracentrifugation to the center of protein research and macromolecule characterization with the next-generation Optima AUC.

From Beckman Coulter Life Sciences - Centrifugation 2 Feb 2017

Blood test that spots tumor DNA predicts survival of advanced breast cancer patients

Results of a multicenter study of 129 women with advanced breast cancer show that a blood test that spots cancer-linked DNA correctly predicted that most of those patients with higher levels of the tumor markers died significantly earlier than those with lower levels.

2 Feb 2017

Autologous hematopoietic cell transplant may induce sustained remission of multiple sclerosis

New clinical trial results provide evidence that high-dose immunosuppressive therapy followed by transplantation of a person's own blood-forming stem cells can induce sustained remission of relapsing-remitting multiple sclerosis (MS), an autoimmune disease in which the immune system attacks the central nervous system.

2 Feb 2017

UNC-Chapel Hill researchers show how human stem cells can hunt and kill brain cancer

In a rapid-fire series of breakthroughs in just under a year, researchers at the University of North Carolina at Chapel Hill have made another stunning advance in the development of an effective treatment for glioblastoma, a common and aggressive brain cancer.

2 Feb 2017

Researchers find chemical link between two problem proteins that cause Parkinson's disease

Researchers report they have discovered how two problem proteins known to cause Parkinson's disease are chemically linked, suggesting that someday, both could be neutralized by a single drug designed to target the link.

2 Feb 2017

Study shows decreased incidence of radiation esophagitis in elderly NSCLC patients

Elderly non-small cell lung cancer (NSCLC) patients undergoing definitive radiation have a lower incidence of esophagitis compared to younger patients and tolerate aggressive standard treatment regimens.

1 Feb 2017

Blocking new genetic marker could alleviate pain from serious burns

The unpleasant sensation sparked by the nervous system when confronted with a harmful stimulus can be alleviated by blocking a genetic marker that switches off the activity of the neurons involved.

1 Feb 2017

Scientists discover way of improving immune system’s memory to recognise and fight cancers

Scientists from the University of Southampton have discovered an important way that the immune system can learn to recognise and fight cancers.

1 Feb 2017

Early predictors of anxiety and depression may be evident in the brain at birth, study suggests

Early predictors of anxiety and depression may be evident in the brain even at birth, suggests a study published in the February 2017 issue of the Journal of the American Academy of Child and Adolescent Psychiatry.

1 Feb 2017

Use of the Quorum Cryo-SEM preparation system in microbial cell biology with electron cryotomography at the Jensen Laboratory

Quorum Technologies, market and technology leaders in electron microscopy coating and cryogenic preparation products, report on how their PP3010T Cryo-SEM preparation system is being used in the preparation of hydrated whole cells to be imaged using electron cryotomography in the Jensen Laboratory located at HHMI Caltech.

1 Feb 2017

Scientists use big data to create map linking breast cancer cell shape and genes

Scientists have created a 'map' linking the shape of breast cancer cells to genes turned on and off, and matched it to real disease outcomes, which could one day help doctors select treatments, according to a study published in Genome Research today (Wednesday).

1 Feb 2017

Defects in key gene spur breast and ovarian cancer growth, study shows

Defects in a key gene - long thought to drive cancer by turning off the protection afforded by the well-known BRCA genes - spur cancer growth on their own, according to a study led by researchers from NYU Langone Medical Center.

31 Jan 2017

Mount Sinai study characterizes genetically modified rat model of autism and intellectual disability

Researchers at The Seaver Autism Center for Research and Treatment at Mount Sinai have generated and characterized a genetically modified rat model of autism and intellectual disability, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published January 31 in the journal eLife.

31 Jan 2017

Long-lived yeast mutants unlock clues to improve health and extend lifespan

Yeast -- it's more than just a fungus. It can also tell us a lot about growing older.

31 Jan 2017

Scientists shed new light on how common painkiller causes liver damage

Scientists have shed new light on how the common painkiller paracetamol causes liver damage.

31 Jan 2017

Cell News and Research

Research unravels molecular mechanisms of antisense oligonucleotides

UW-Madison scientists discover bone marrow proteins that regulate bone-building cells

Virulence of bacterial infections dependent on presence of cytotoxins, study reports

Researchers identify new mechanism that protects from bacterial infections

Nicotine creates cascade of effects in the brain that get worse over time

Launch of next-generation Optima AUC advances protein research and macromolecule characterization

Blood test that spots tumor DNA predicts survival of advanced breast cancer patients

Autologous hematopoietic cell transplant may induce sustained remission of multiple sclerosis

UNC-Chapel Hill researchers show how human stem cells can hunt and kill brain cancer

Researchers find chemical link between two problem proteins that cause Parkinson's disease

Study shows decreased incidence of radiation esophagitis in elderly NSCLC patients

Blocking new genetic marker could alleviate pain from serious burns

Scientists discover way of improving immune system’s memory to recognise and fight cancers

Early predictors of anxiety and depression may be evident in the brain at birth, study suggests

Use of the Quorum Cryo-SEM preparation system in microbial cell biology with electron cryotomography at the Jensen Laboratory

Scientists use big data to create map linking breast cancer cell shape and genes

Defects in key gene spur breast and ovarian cancer growth, study shows

Mount Sinai study characterizes genetically modified rat model of autism and intellectual disability

Long-lived yeast mutants unlock clues to improve health and extend lifespan

Scientists shed new light on how common painkiller causes liver damage

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