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New generation of CRISPR shows safer path to treating genetic diseases

A new generation of CRISPR technology developed at UNSW Sydney offers a safer path to treating genetic diseases like Sickle Cell, while also proving beyond doubt that chemical tags on DNA - often thought to be little more than genetic cobwebs - actively silence genes.

17 Aug 2025

Trial finds no cardiovascular benefit and higher safety risks with spironolactone in dialysis patients

A large international study has found that spironolactone, a medication for high blood pressure and heart failure, does not reduce the risk of heart-related death or hospitalizations in people with kidney failure receiving dialysis, despite earlier smaller studies suggesting benefit.

17 Aug 2025

Respiratory viruses awaken dormant breast cancer cells and raise relapse risk

Respiratory viruses such as influenza and COVID-19 can reactivate dormant breast cancer cells in the lungs, raising the risk of metastasis. The process is driven by IL-6–induced cell changes and immune suppression, with the highest recurrence risk soon after infection.

14 Aug 2025

GIPR signaling opens brain’s gate for GLP-1 weight-loss therapy

A Cell Metabolism study reveals that GIPR signaling in oligodendrocytes enhances brain access and weight-loss efficacy of GLP-1R agonists by increasing vascular permeability and targeting appetite-regulating neurons. This mechanism may explain why GIPR/GLP-1R co-agonists outperform single-agent therapies.

14 Aug 2025

Reengineered enzyme enables precise detection of cell surface glycans

Sugars known as glycans form dense envelopes around cells. But they're often ignored in biological investigations because, unlike DNA, proteins and other cellular components, tools to study them are lacking.

14 Aug 2025

Engineered telomerase RNA offers temporary boost to telomere length in human stem cells

Much the way the caps on the ends of a shoelace prevent it from fraying, telomeres - regions of repetitive DNA sequences and a protein structure - protect the tips of chromosomes from damage.

14 Aug 2025

Diagnostic mimicry and management of rare pure form of ovarian cancer

A new case report was published in Volume 12 of Oncoscience on July 28, 2025, titled "A rare case of pure non-gestational ovarian choriocarcinoma: Diagnostic mimicry and management strategies."

14 Aug 2025

Systems biology identifies sentinel biomarkers bridging ankylosing spondylitis and myocardial infarction

Ankylosing spondylitis (AS) is increasingly recognized as an independent risk factor for premature myocardial infarction (MI), yet the molecular bridge linking chronic axial inflammation to acute coronary events remains poorly mapped.

14 Aug 2025

New 2025 guidelines focus on early intervention and lifestyle to manage high blood pressure

Preventing and managing high blood pressure with healthy lifestyle behaviors, such as following a heart-healthy diet including reducing salt intake, staying physically active, maintaining a healthy weight and managing stress—combined with early treatment with medication to lower blood pressure if necessary—are recommended to reduce the risk of heart attack, stroke, heart failure, kidney disease, cognitive decline and dementia, according to a new clinical guideline published today in the American Heart Association's peer-reviewed journals Circulation and Hypertension, and in JACC, the flagship journal of the American College of Cardiology.

14 Aug 2025

Dual epigenetic marks found to regulate cell identity

Shedding light on what determines how cells become what they are meant to be-nerves, bone, muscles, etc.-can also help researchers understand how diseases develop when these biological programs break down.

14 Aug 2025

Mayo Clinic identifies cellular 'fountain of youth' in aging immune systems

The immune system is meant to protect the body from infection and disease. But with age, it can become less capable of doing so.

14 Aug 2025

Microbial DNA signature in the blood differentiates primary liver cancer from metastatic colorectal cancer

Determining whether a cancerous tumor originated in a given location or spread there from another tissue or organ in the body is important when assessing the likely course of a patient's disease.

14 Aug 2025

Diabetes drugs linked to higher risk of rare optic nerve damage

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14 Aug 2025

Triglycerides identified as direct cause of abdominal aortic aneurysms

High levels of triglycerides, the most common type of fat in the body and the foods we eat, directly cause abdominal aortic aneurysms, according to a study in mouse models led by Michigan Medicine.

14 Aug 2025

Genicular artery embolization relieves chronic knee pain caused by osteoarthritis

A procedure performed under mild sedation in less than two hours by an interventional radiologist relieves chronic knee pain caused by osteoarthritis, an NYU Langone Health study shows.

14 Aug 2025

PFAS exposure increases risk of weight regain after adolescent bariatric surgery

Adolescents who undergo bariatric surgery face a higher risk of weight regain, which can undermine treatment success and long-term health, if they have elevated blood levels of per- and polyfluoroalkyl substances (PFAS) prior to the procedure, according to new USC research.

14 Aug 2025

‘A fear pandemic’: Immigration raids push patients into telehealth

Jacob Sweidan has seen his patients through the federal immigration raids of the 1990s, a sitting governor's call to abolish birthright citizenship, and the highly publicized workplace crackdowns and family separation policies of President Donald Trump's first term.

14 Aug 2025

HonorHealth taps longevity authority Nicholas J. Schork to lead new research division

Nicholas J. Schork, Ph.D., an international authority on human longevity and health maintenance, has joined HonorHealth Research Institute as Research Director of Longevity, Prevention and Interception.

14 Aug 2025

Early use of risdiplam in newborns with SMA shows improvements in motor development

Spinal muscular atrophy (SMA) is a rare genetic condition that causes progressive muscle weakness, which, when untreated, prevents infants with the most severe form from gaining motor development - never gaining the ability to sit - and typically leads to death before 2 years of age.

13 Aug 2025

Research shows GLP-1 drugs safeguard vision despite small retinopathy risk

A large study of over 185,000 adults with type 2 diabetes found that GLP-1 receptor agonist use was linked to a slight increase in new diabetic retinopathy cases but fewer severe eye complications, including a reduced risk of blindness. Patients with existing retinopathy on these drugs also needed fewer invasive eye treatments over two years.

13 Aug 2025

Blood News and Research

New generation of CRISPR shows safer path to treating genetic diseases

Trial finds no cardiovascular benefit and higher safety risks with spironolactone in dialysis patients

Respiratory viruses awaken dormant breast cancer cells and raise relapse risk

GIPR signaling opens brain’s gate for GLP-1 weight-loss therapy

Reengineered enzyme enables precise detection of cell surface glycans

Engineered telomerase RNA offers temporary boost to telomere length in human stem cells

Diagnostic mimicry and management of rare pure form of ovarian cancer

Systems biology identifies sentinel biomarkers bridging ankylosing spondylitis and myocardial infarction

New 2025 guidelines focus on early intervention and lifestyle to manage high blood pressure

Dual epigenetic marks found to regulate cell identity

Mayo Clinic identifies cellular 'fountain of youth' in aging immune systems

Microbial DNA signature in the blood differentiates primary liver cancer from metastatic colorectal cancer

Diabetes drugs linked to higher risk of rare optic nerve damage

Triglycerides identified as direct cause of abdominal aortic aneurysms

Genicular artery embolization relieves chronic knee pain caused by osteoarthritis

PFAS exposure increases risk of weight regain after adolescent bariatric surgery

‘A fear pandemic’: Immigration raids push patients into telehealth

HonorHealth taps longevity authority Nicholas J. Schork to lead new research division

Early use of risdiplam in newborns with SMA shows improvements in motor development

Research shows GLP-1 drugs safeguard vision despite small retinopathy risk

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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