Immune Response News and Research

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Study points to a novel strategy for developing broad-spectrum vaccines against coronaviruses

Scientists from Duke-NUS Medical School and the National Centre for Infectious Diseases (NCID) found that 2003 SARS survivors who have been vaccinated with the Pfizer-BioNTech mRNA vaccine produced highly potent functional antibodies that are capable of neutralizing not only all known SARS-CoV-2 variants of concerns (VOCs) but also other animal coronaviruses that have the potential to cause human infection.

20 Aug 2021

Scientists develop a new way to deliver molecular therapies to cells

Researchers from MIT, the McGovern Institute for Brain Research at MIT, the Howard Hughes Medical Institute, and the Broad Institute of MIT and Harvard have developed a new way to deliver molecular therapies to cells.

19 Aug 2021

Existing drugs block or reduce SARS-CoV2 infection in cells

Since the beginning of the pandemic, researchers worldwide have been looking for ways to treat COVID-19. And while the COVID-19 vaccines represent the best measure to prevent the disease, therapies for those who do get infected remain in short supply.

19 Aug 2021

SARS-CoV-2 antibodies found to neutralize bat coronavirus (RaTG13) in new study

A striking new study examines how far antibodies elicited by vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or by natural infection, can neutralize the closely related bat coronavirus (CoV) RaTG13.

19 Aug 2021

How does the SARS-CoV-2 Delta variant’s spike drive membrane fusion and immunity evasion?

A fascinating and timely new study shows how the Delta variant of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) achieved higher transmissibility and resistance to neutralization.

19 Aug 2021

Durable highly protective T cell response to AAV-spike vaccine against COVID-19 pneumonia in mice

New research, available as a preprint on the bioRxiv* server, has focused on the role played by T cell immunity, particularly CD8+ cytotoxic T cells, on preventing lethal infection with SARS-CoV-2 in mice infused with peptide-loaded antigen-presenting dendritic cells (DCs).

19 Aug 2021

Did particulate matter from wildfires cause excess COVID-19 deaths in the US?

New research published in Science Advances investigates the relationship between wildfire smoke and COVID-19 mortality using pollution and COVID-19 incidence and mortality data.

19 Aug 2021

Early clinical trial data in for whole virus COVID-19 vaccine candidate

In a study uploaded to the preprint server medRxiv*, the efficacy of a whole virion Coronavirus vaccine was determined by giving the vaccine to healthy adult volunteers, which generated a robust immune response with evidence of T-cell activation.

19 Aug 2021

SARS-CoV-2 vaccine efficacy is strongly correlated with antibody neutralization levels

All COVID-19 vaccines appear less effective when faced with variants such as Delta, according to a new medRxiv* study. However, the researchers suggest that booster shots may help improve immunity and protect against symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

18 Aug 2021

Severe COVID-19 characterized by phosphorylation of STAT1

A new study reports an enhanced expression of STAT1 in mild and severely infected COVID-19 patients as compared to controls

18 Aug 2021

The White House says boosters for all. Here’s what you need to know.

The Biden administration announced plans Wednesday to offer boosters to all U.S. adults as soon as next month, saying that recent data, including some made available only in the past few days, played a role in that decision.

18 Aug 2021

Rush to boosters sparks confusion, differing recommendations

When the Food and Drug Administration announced last week that a third dose of Moderna or Pfizer-BioNTech covid-19 vaccine may boost the immunity of some people who are immunocompromised, officials repeated their stance that fully vaccinated, healthy people do not need another dose.

18 Aug 2021

Naive B cells could be useful for predicting vaccination response in immunocompromised

A recent study conducted at the Medical University of Graz, Austria, has revealed that the number of naïve B cells in the blood could independently predict the magnitude of immune response induced by coronavirus disease 2019 (COVID-19) vaccines in immunocompromised patients. The study is currently available on the medRxiv* preprint server.

17 Aug 2021

Delta variant unable to evade antibodies elicited by COVID-19 vaccination, finds study

Despite causing a surge in infections this summer that has resulted in thousands of hospitalizations and deaths, the delta variant of the virus that causes COVID-19 is not particularly good at evading the antibodies generated by vaccination, according to a study by researchers at Washington University School of Medicine in St. Louis.

17 Aug 2021

Immune Response News and Research

Study points to a novel strategy for developing broad-spectrum vaccines against coronaviruses

Scientists develop a new way to deliver molecular therapies to cells

Existing drugs block or reduce SARS-CoV2 infection in cells

SARS-CoV-2 antibodies found to neutralize bat coronavirus (RaTG13) in new study

How does the SARS-CoV-2 Delta variant’s spike drive membrane fusion and immunity evasion?

Durable highly protective T cell response to AAV-spike vaccine against COVID-19 pneumonia in mice

Did particulate matter from wildfires cause excess COVID-19 deaths in the US?

Early clinical trial data in for whole virus COVID-19 vaccine candidate

SARS-CoV-2 vaccine efficacy is strongly correlated with antibody neutralization levels

Severe COVID-19 characterized by phosphorylation of STAT1

The White House says boosters for all. Here’s what you need to know.

Rush to boosters sparks confusion, differing recommendations

Naive B cells could be useful for predicting vaccination response in immunocompromised

Delta variant unable to evade antibodies elicited by COVID-19 vaccination, finds study

UC Davis Health offers third dose COVID-19 'booster' shots to immunocompromised patients

Research shines light on histamine as a potential key player in depression

Study explores the role of nasal bacteria and provides clues to developing better flu, COVID-19 vaccines

New clinical trial investigates aspirin as part of new treatment for triple negative breast cancer

In Southeast Asia, robust immunity found up to 9 months after SARS-CoV-2 infection

Hedgehog-signaling inhibitor may shift tumor-associated macrophages back to cancer fighters

Exploring Strategies for Targeting Kinases in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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