Angiotensin Converting Enzyme 2 News and Research

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Chronic liver disease in COVID-19 patients

A recent study summarizes the clinical outcomes of COVID-19 patients with chronic liver disease.

10 Oct 2022

Silver nanoparticle and polyurethane composite provides potential coating options to limit fomite transmission of SARS-CoV-2

In a new study, researchers synthesized and evaluated a silver and polyurethane nanocomposite surface coating material that exhibits antiviral activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

7 Oct 2022

Histone mimicry by SARS-CoV-2 protein disrupts epigenetic regulation of host cells

Researchers demonstrated that the SARS-CoV-2 protein functions as a histone mimic to disrupt the epigenetic regulation of host cells.

7 Oct 2022

Study evaluates efficacy of a candidate SARS-CoV-2 subunit vaccine to protect endangered black-footed-ferrets

In a new study, researchers assessed the safety, efficacy, and immunogenicity of a candidate SARS-CoV-2 subunit vaccine in black-footed ferrets (BFF), and investigated the susceptibility of these endangered North American mammals to the virus.

7 Oct 2022

Neonatal mice-based model established that allows for the transmission of clinical SARS-CoV-2 isolates

Researchers established a neonatal mice model that enabled SARS-CoV-2 transmission.

7 Oct 2022

Study using human and animal-derived cell lines suggests human origin of SARS-CoV-2 Omicron variant

Researchers examined the replicative capacity of seven SARS-CoV-2 isolates in 17 cell lines to understand their phenotypic variations and host range.

7 Oct 2022

Study suggests an immunological benefit of combining previous natural infection with vaccination against COVID-19 using a combination of different vaccine platforms

Researchers explored SARS-CoV-2-targeted immune responses among COVAC1 participants who received a novel saRNA vaccine followed by the mRNA BNT162b2 vaccine BNT162b2 vaccine, with or without prior COVID-19 history.

7 Oct 2022

Three-dimensional in vitro model to reproduce COVID-19-induced endothelial dysfunction

In a new study, researchers developed a three-dimensional (3D) in vitro tissue model to assess the effects of SARS-CoV-2 on the vascular endothelial cells.

5 Oct 2022

Yeast display used to generate SARS-CoV-2 RBD-specific nanobodies

Researchers engineered biparatopic nanobodies against SARS-CoV-2.

5 Oct 2022

Novel protein vaccine NVX-CoV2373 triggered functional T cell responses to SARS-CoV-2

Researchers determined the T cell response to the NVX-CoV2373, an adjuvanted recombinant full-length SARS-CoV-2 spike (S) trimer protein vaccine.

5 Oct 2022

Study shows SARS-CoV-2 infects human adipose tissue and undergoes productive infection in fat cells

Researchers demonstrated infection of human adipose tissue by SARS-CoV-2.

5 Oct 2022

Omicron reduces host antibody response by lower B-cell antigenicity

A new study explores the functional relevance of some Omicron mutations in terms of their ability to escape neutralizing antibody responses.

4 Oct 2022

What are the challenges of COVID-19 vaccination and herd immunity?

A new study reviewed the challenges of coronavirus disease 2019 (COVID-19) vaccination and herd immunity.

4 Oct 2022

How COVID-19 affects the female reproductive system

A new review in the Biology of Reproduction journal analyzed the relationship between the immune system and the female reproductive system while focusing on the effects of COVID-19-associated immune responses on the reproductive system. The study searched PubMed to identify peer-reviewed literature in English up to May 2022 and finally included 83 studies.

3 Oct 2022

Researchers report aminoadamantanes that block SARS-CoV-2 infection by S-nitrosylation of the host ACE2 protein

Researchers investigated the use of aminoadamantane nitrate compounds as anti-SARS-CoV-2 drugs.

3 Oct 2022

Novel linear DNA SARS-CoV-2 vaccine using electroporation-aided vaccine delivery reveals lower viral shedding in ferrets

Researchers evaluated the efficacy, immunogenicity, and safety of a novel SARS-CoV-2 linear deoxyribonucleic acid vaccine in ferret models delivered using intramuscular injection and electroporation.

3 Oct 2022

Broadly neutralizing antibodies are the blueprint for variant-proof, pansarbecovirus vaccines

A recent Nature Reviews Immunology study has summarized the efficacy of neutralizing antibodies that target four main regions of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), namely, the receptor-binding domain (RBD) in the S1 subunit, the fusion peptide region in the S2 subunit, the stem helix region, and the N-terminal domain.

2 Oct 2022

SARS-CoV-2 spike protein and messenger ribonucleic acid found to translocate into the nucleus

In a new study, researchers reported severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) spike (S) protein and S messenger ribonucleic acid (mRNA) nuclear co-translocation as a novel feature of SARS-CoV-2 pathogenesis.

30 Sep 2022

Effectiveness of anti-SARS-CoV-2 immunoadhesin against omicron and other emerging variants

A new study demonstrated the efficacy of a newly engineered angiotensin-converting enzyme 2 (ACE2) based immunoadhesin against Omicron and other SARS-CoV-2 VOCs.

30 Sep 2022

Bioactive compounds derived from Ganoderma lucidum exhibit anti-SARS-CoV-2 activity

Scientists have identified lucidenic acid A, one of the bioactive compounds of Ganoderma lucidum, as a potential inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) host cell entry. The study has recently been published in the journal Food and Chemical Toxicology.

29 Sep 2022

Angiotensin Converting Enzyme 2 News and Research

Chronic liver disease in COVID-19 patients

Silver nanoparticle and polyurethane composite provides potential coating options to limit fomite transmission of SARS-CoV-2

Histone mimicry by SARS-CoV-2 protein disrupts epigenetic regulation of host cells

Study evaluates efficacy of a candidate SARS-CoV-2 subunit vaccine to protect endangered black-footed-ferrets

Neonatal mice-based model established that allows for the transmission of clinical SARS-CoV-2 isolates

Study using human and animal-derived cell lines suggests human origin of SARS-CoV-2 Omicron variant

Study suggests an immunological benefit of combining previous natural infection with vaccination against COVID-19 using a combination of different vaccine platforms

Three-dimensional in vitro model to reproduce COVID-19-induced endothelial dysfunction

Yeast display used to generate SARS-CoV-2 RBD-specific nanobodies

Novel protein vaccine NVX-CoV2373 triggered functional T cell responses to SARS-CoV-2

Study shows SARS-CoV-2 infects human adipose tissue and undergoes productive infection in fat cells

Omicron reduces host antibody response by lower B-cell antigenicity

What are the challenges of COVID-19 vaccination and herd immunity?

How COVID-19 affects the female reproductive system

Researchers report aminoadamantanes that block SARS-CoV-2 infection by S-nitrosylation of the host ACE2 protein

Novel linear DNA SARS-CoV-2 vaccine using electroporation-aided vaccine delivery reveals lower viral shedding in ferrets

Broadly neutralizing antibodies are the blueprint for variant-proof, pansarbecovirus vaccines

SARS-CoV-2 spike protein and messenger ribonucleic acid found to translocate into the nucleus

Effectiveness of anti-SARS-CoV-2 immunoadhesin against omicron and other emerging variants

Bioactive compounds derived from Ganoderma lucidum exhibit anti-SARS-CoV-2 activity

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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