Programmed Cell Death News and Research

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Non-coding RNAs play key role in maintaining proper balance between fighting infection and inflammation

Special RNA molecules called long non-coding RNAs (lncRNAs) are key controllers for maintaining immune health when fighting infection or preventing inflammatory disorders, according to research led by Jorge Henao-Mejia, MD, PhD, an assistant professor of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of Pennsylvania.

25 Aug 2016

Novel marine natural product appears to reduce pancreatic tumor size

Scientists at Florida Atlantic University's Harbor Branch Oceanographic Institute found that a deep-water marine sponge collected off of Fort Lauderdale's coast contains leiodermatolide, a natural product that has the ability to inhibit the growth of cancer cells as well as block cancer cells from dividing using extremely low concentrations of the compound.

18 Aug 2016

Could nanotechnology turn the cancer cell suicide switch back on? An interview with Professor Dipanjan Pan

Before I explain the discovery, I would take a step back and explain an interesting event that takes place in the cancer cells. Normal cells follow a rapid and irreversible process to efficiently eradicate dysfunctional cells. This is a natural process by which damaged cells commit ‘suicide’. This process is known as apoptosis or programmed cell death.

15 Aug 2016

SBP board member donates $1M for researchers to study pancreatic and prostate cancer

Sanford Burnham Prebys Medical Discovery Institute (SBP) has received a $1M donation from The Epstein Family Foundation for scientists to study pancreatic and prostate cancer.

10 Aug 2016

TUM scientists discover molecular signaling pathway for self-destruction in leukemia cells

When adults develop blood cancer, they are frequently diagnosed with what is referred to as acute myeloid leukemia.

15 Jul 2016

Scientists detect first cell from which tumour grows in skin cancers

Scientists have identified for the first time the 'cell of origin' - in other words, the first cell from which the cancer grows - in basal cell carcinoma, the most common form of skin cancer, and followed the chain of events that lead to the growth of these invasive tumours.

11 Jul 2016

Researchers identify potential biomarkers predictive of TKIs response in metastatic renal cancer

A team of CNIO researchers, in collaboration with the Spanish Oncology Genitourinary Group and the University Hospitals Leuven, has discovered various potential biomarkers predictive of tyrosine kinase inhibitors (TKIs) response in metastatic renal cancer.

8 Jul 2016

Already-approved drugs can fight apoptosis evasion in cancer

Cancer cells don't die when they're supposed to. Animal and human bodies follow an orderly process of birthing new cells and killing old ones. But cancer cells escape programmed cell death, called apoptosis, and multiply uncontrollably.

15 Jun 2016

Study underscores importance of developing PRMT5 inhibitors as promising treatment for GB patients

A new study suggests that blocking an enzyme called PRMT5 in tumor cells could be a promising new strategy for the treatment of glioblastoma (GB), the most aggressive and lethal form of brain cancer.

14 Jun 2016

Researchers design ProAgio protein that may potentially treat cancer, other illnesses

A protein designed by researchers at Georgia State University can effectively target a cell surface receptor linked to a number of diseases, showing potential as a therapeutic treatment for an array of illnesses, including cancer, according to the research team.

1 Jun 2016

Novel way of directly activating Bak protein can trigger cell death

Melbourne researchers have discovered a new way of triggering cell death, in a finding that could lead to drugs to treat cancer and autoimmune disease.

27 May 2016

TSRI study shows how specific gene mutation promotes growth of aggressive tumors

Scientists at The Scripps Research Institute have caught a cancer-causing mutation in the act. A new study shows how a gene mutation found in several human cancers, including leukemia, gliomas and melanoma, promotes the growth of aggressive tumors.

27 May 2016

RBFOX2 dysregulation may cause heart damage in diabetic patients

Cardiac complications are the number one cause of death among diabetics. Now a team of scientists has uncovered a molecular mechanism involved in a common form of heart damage found in people with diabetes.

27 May 2016

Researchers identify potential ways in which cancer cells may develop resistance to BET inhibitors

A team of Walter and Eliza Hall Institute researchers has worked out how a new class of anti-cancer drugs kills cancer cells, a finding that helps explain how cancer cells may become resistant to treatment.

23 May 2016

Scientists visualize apoptosis in live zebrafish using FLIM OPT method

A promising approach for watching cell signaling processes in their physiological context: Scientists visualize apoptosis in live zebrafish using fluorescence lifetime imaging with optical projection tomography to map FRET biosensor activity in space and time.

11 May 2016

TSRI scientists design potential drug candidate to treat triple negative breast cancer

In a development that could lead to a new generation of drugs to precisely treat a range of diseases, scientists from the Florida campus of The Scripps Research Institute have for the first time designed a drug candidate that decreases the growth of tumor cells in animal models in one of the hardest to treat cancers—triple negative breast cancer.

10 May 2016

Biomedical researcher wins 2016 Gutenberg Research Award for work on programmed cell death

The Gutenberg Research College of Johannes Gutenberg University Mainz has chosen to give the 2016 Gutenberg Research Award to American biomedical researcher Dr. Vishva Dixit for his groundbreaking work in the field of programmed cell death.

4 May 2016

KEYNOTE-001 findings add support to pembrolizumab for advanced melanoma

A third of patients with advanced or metastatic melanoma will achieve an objective response to treatment with the programmed cell death protein inhibitor pembrolizumab, suggest KEYNOTE-001 findings, regardless of whether they have previously been treated with ipilimumab.

21 Apr 2016

Distribution of c-Myc protein during asymmetric cell division influences fate, roles of activated T cells

The fates of immune cells can be decided at the initial division of a cell. Researchers at St. Jude Children's Research Hospital have discovered that the production of daughter cells with different roles in the immune system is driven by the lopsided distribution of the signaling protein c-Myc. Nudging c-Myc in one direction or the other could make vaccines more effective or advance immunotherapies for cancer treatment. The research appears online today in the scientific journal Nature.

12 Apr 2016

Rockefeller scientists study molecular mechanism that causes linker cell death in worms

Some cells are meant to live, and some are meant to die. The linker cell of Caenorhabditis elegans, a tiny worm that is a favored model organism for biologists, is among those destined for termination.

11 Apr 2016

Programmed Cell Death News and Research

Non-coding RNAs play key role in maintaining proper balance between fighting infection and inflammation

Novel marine natural product appears to reduce pancreatic tumor size

Could nanotechnology turn the cancer cell suicide switch back on? An interview with Professor Dipanjan Pan

SBP board member donates $1M for researchers to study pancreatic and prostate cancer

TUM scientists discover molecular signaling pathway for self-destruction in leukemia cells

Scientists detect first cell from which tumour grows in skin cancers

Researchers identify potential biomarkers predictive of TKIs response in metastatic renal cancer

Already-approved drugs can fight apoptosis evasion in cancer

Study underscores importance of developing PRMT5 inhibitors as promising treatment for GB patients

Researchers design ProAgio protein that may potentially treat cancer, other illnesses

Novel way of directly activating Bak protein can trigger cell death

TSRI study shows how specific gene mutation promotes growth of aggressive tumors

RBFOX2 dysregulation may cause heart damage in diabetic patients

Researchers identify potential ways in which cancer cells may develop resistance to BET inhibitors

Scientists visualize apoptosis in live zebrafish using FLIM OPT method

TSRI scientists design potential drug candidate to treat triple negative breast cancer

Biomedical researcher wins 2016 Gutenberg Research Award for work on programmed cell death

KEYNOTE-001 findings add support to pembrolizumab for advanced melanoma

Distribution of c-Myc protein during asymmetric cell division influences fate, roles of activated T cells

Rockefeller scientists study molecular mechanism that causes linker cell death in worms

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