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Researchers discover mechanism of gene silencing in hormone-dependent breast cancer cells

Sometimes, the silencing of a gene is as important as its activation. Nonetheless, up to now, most studies on hormone-mediated gene regulation have focused on researching the factors that influence the activation of certain genes. Little attention has been paid to gene silencing.

8 Jul 2016

Extra-coding RNA modulates neuronal DNA methylation patterns

The creation of memories in the brain involves addition or removal of methyl groups at precise spots on chromosomal DNA. But what controls the careful targeting of these neuronal DNA methylation dynamics?

8 Jul 2016

Scientists use stem cell techniques to unravel biology of autism

The brains of some people with autism spectrum disorder grow faster than usual early on in life, often before diagnosis.

8 Jul 2016

Study proves cells can send ephrins and Ephs out to transmit signals

Eph receptors and their partner proteins, the ephrins, are vital for intercellular communication.

8 Jul 2016

Public urinals can generate electricity with help of bacterial metabolism

Pee can be transformed into electricity with the help of bacterial metabolism, thanks to a device created by researchers at the University of the West of England, where Spanish researchers are working.

8 Jul 2016

Pediatric health educator provides tips for protecting children from heat stroke

Hot temperatures and high humidity can put nearly anyone at risk for dehydration and heat stroke, but children are especially vulnerable.

7 Jul 2016

Study shows twice daily exercise intervention improves bone strength in VLBW pre-term infants

Because of their low weight and premature birth, very low birth weight (VLBW) pre-term infants have lower bone mineral mass and a greater need for bone nutrients compared to most new-born infants.

7 Jul 2016

New genetic test provides rapid diagnosis of mitochondrial disease

Newcastle researchers have developed a genetic test providing a rapid diagnosis of mitochondrial disorders to identify the first patients with inherited mutations in a new disease gene.

7 Jul 2016

Research sheds new light on development of chronic inflammatory diseases

Research from life scientists at The University of Manchester has shone new light on the way cells tune in to different inflammatory signals to understand what is happening in the body.

7 Jul 2016

Innovative nanobubble treatment finds and destroys cancer cells in mice

Innovative technology developed by NIH-funded researchers has been able to find and facilitate the killing of cancer cells in mice without harming the nearby healthy tissue.

7 Jul 2016

Clinical trial to evaluate safety of palbociclib drug in African American women with breast cancer

The first clinical trial to test a newly approved breast cancer drug specifically in African American patients is now enrolling at Georgetown Lombardi Comprehensive Cancer Center and will begin soon at five other institutions in Washington, DC, Maryland, Alabama and New Jersey.

7 Jul 2016

Mitochondrial stress can trigger tumor-related metabolic shifts, study finds

Cancerous tumors must be fed. Their unregulated growth requires a steady stream of blood flow and nutrients. Thus, one way that researchers have tried to wipe out cancer is to target cells undergoing the metabolic shifts that enable a tumor's rapid growth.

7 Jul 2016

New microfluidic device allows scientists to use safe electric fields to treat cancer

Researchers at MIT's research center in Singapore have developed a new microfluidic device that tests the effects of electric fields on cancer cells.

7 Jul 2016

Experts discuss potential of DNA origami

Ten years after its introduction, DNA origami, a fast and simple way to assemble DNA into potentially useful structures, is finally coming into its own.

7 Jul 2016

Buck researchers find new way for possible treatment of AMD

Buck researchers boosted the potency of a broccoli-related compound by ten times and identified it as a possible treatment for age-related macular degeneration (AMD), the leading cause of vision loss affecting more than 10 million older Americans.

7 Jul 2016

Scientists discover key cellular mechanism behind side-effects of antipsychotics

Since their development in the 1950s, antipsychotic drugs have been widely used to treat psychoses and neuropsychiatric disorders like schizophrenia. A debilitating side-effect of these drugs called parkinsonism limits their efficacy.

7 Jul 2016

Review examines role of gut microbes in development, progression of MS

An increasing number of clinical studies are pointing to a link between the autoimmune disease multiple sclerosis (MS) and the composition of microbes in the human gut, sparking new research on the gut microbiome as a potential target for MS treatment and prevention.

7 Jul 2016

Minoryx Therapeutics initiates phase 1 clinical trial of MIN-102

Minoryx Therapeutics, a drug development company specialized in the discovery and development of new drugs for orphan diseases, today announces the initiation of its first-in-man Phase 1 clinical trial for its lead compound MIN-102.

7 Jul 2016

AMPK protein activated during fasting regulates hunger neurons in the brain

Neurons in the brain that control hunger are regulated by AMPK, a protein activated during fasting, report researchers from Tufts University School of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School in Neuron on July 6, 2016.

6 Jul 2016

Existing anti-inflammatory drugs may be effective in treating epilepsy

In epileptic patients, seizures lead to an increased level of inflammation-related proteins called chemokines in the brain, and systemic inflammation likely helps trigger and promote the recurrence of seizures, making inflammation a promising new target for anticonvulsant therapy.

6 Jul 2016