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Phase 2 IMAGO trial of SHP625 fails to meet primary endpoints in pediatric patients with ALGS

Shire plc today announced that the 13-week Phase 2 IMAGO trial of its investigational compound SHP625 (LUM001) did not meet the primary or secondary endpoints in the study of 20 pediatric patients with Alagille syndrome (ALGS), a rare, life-threatening genetic disorder that presents with chronic cholestasis (accumulation of bile acids in the liver) and severe pruritus (itching).

9 Apr 2015

New study describes economic consequences of using T2Candida Panel for detection of candidemia

A new study describes a model that estimates the economic consequences of using the T2Candida Panel (a novel diagnostic product that provides Candida detection) as an adjunct to the current blood culture-based diagnostic strategy in a high-risk hospital patient cohort.

9 Apr 2015

Diet rich in high glucoraphanin broccoli reduces blood LDL-cholesterol levels by around 6%

Including a new broccoli variety in the diet reduces blood LDL-cholesterol levels by around 6%, according to the results of human trials led by the Institute of Food Research.

9 Apr 2015

TABS study: Older people can improve their health by reducing sitting time

"I feel lethargic when I sit all day," said Gerald Alexander, an 82-year-old retired social service worker among the 25 Group Health patients who participated in the Take Active Breaks from Sitting (TABS) pilot study. "I feel much peppier when I stand and take walks."

9 Apr 2015

UTMB scientists develop quick-acting vaccine that is effective against Ebola strain

An interdisciplinary team from The University of Texas Medical Branch at Galveston and Profectus BioSciences, Inc. has developed a quick-acting vaccine that is both safe and effective with a single dose against the Ebola strain that killed thousands of people in West Africa last year.

8 Apr 2015

Study: Standard nursing assessments may help improve outcomes in cirrhosis patients

Patients hospitalized with advanced cirrhosis, a chronic and degenerative disease of the liver, are at increased risk of death. The tools currently used to assess that risk are limited in predicting which patients will need a liver transplant and which will be healthy enough to survive transplantation.

8 Apr 2015

Changes in height can affect risk of coronary heart disease

The shorter you are- the more your risk of coronary heart disease. That's the key finding of a new study led by the University of Leicester which discovered that every 2.5 inches change in your height affected your risk of coronary heart disease by 13.5%. For example, compared to a 5ft 6inch tall person, a 5 foot tall person on average has a 32% higher risk of coronary heart disease because of their relatively shorter stature.

8 Apr 2015

Prolong Pharmaceuticals' SANGUINATE granted FDA Orphan Drug Designation for SCD treatment

Prolong Pharmaceuticals, LLC, a biopharmaceutical company dedicated to developing products for the treatment of anemias, cancers and their debilitating comorbidities, announced today that the U.S. Food and Drug Administration has granted Orphan Drug Designation for its flagship product SANGUINATE for the treatment of Sickle Cell Disease (SCD).

8 Apr 2015

TSRI scientists find molecular trigger of schizophrenia-like behaviors and brain changes

According to the World Health Organization, more than 21 million people worldwide suffer from schizophrenia, a severe psychiatric disorder that can cause delusions and hallucinations and lead to increased risk of suicide...

8 Apr 2015

New simeprevir clinical data to be presented at EASL's International Liver Congress 2015

Janssen Sciences Ireland UC, one of the Janssen Pharmaceutical Companies of Johnson & Johnson, today announced that clinical data for simeprevir, its NS3/4A protease inhibitor for the treatment of hepatitis C virus (HCV) infection, will be presented at The International Liver Congress 2015 of the European Association for the Study of the Liver taking place in Vienna from April 22-26.

8 Apr 2015

Scientists identify brain molecule that triggers schizophrenia-like behaviors, brain changes

Scientists at The Scripps Research Institute have identified a molecule in the brain that triggers schizophrenia-like behaviors, brain changes and global gene expression in an animal model. The research gives scientists new tools for someday preventing or treating psychiatric disorders such as schizophrenia, bipolar disorder and autism.

8 Apr 2015

CUMC researchers identify cellular defect that could lead to potential new treatment for diabetes

A cellular defect that can impair the body's ability to handle high glucose levels and could point the way to a potential new treatment for diabetes has been identified by Columbia University Medical Center researchers.

8 Apr 2015

New study could point to potential ways to address defects in learning, memory

Just as some people seem built to run marathons and have an easier time going for miles without tiring, others are born with a knack for memorizing things, from times tables to trivia facts. These two skills—running and memorizing—are not so different as it turns out.

8 Apr 2015

Two case studies provide potential new avenue for treatment of kidney cancer

UT Southwestern Medical Center Kidney Cancer Program investigators have published what is believed to be the first reported successful use of stereotactic body radiation therapy for an often deadly complication of kidney cancer.

8 Apr 2015

Study identifies gut immune system as new, effective target for diabetes

A commonly-used drug to treat inflammatory bowel disease, such as Crohn's disease, has been shown to lower blood sugar levels in obese mice, potentially identifying the gut immune system as a new and effective target in treating diabetes in humans.

8 Apr 2015

Research finding may lead to new potential therapeutic targets for lung cancer

Lung cancer is the second most common type of cancer and the number one cause of cancer-related mortality. It is estimated that more than 158,000 people will die from lung cancer in the United States this year. Many scientists believe that targeting a type of cell called a cancer stem cell may be necessary to completely cure lung cancer.

8 Apr 2015

Researchers assess how chronic stress and relationship quality influence individual's blood pressure

While other studies have shown that stress and negative marital quality can influence mortality and blood pressure, there has not been research that discussed how it might affect married couples over time. Using systolic blood pressure as a gauge, researchers assessed whether an individual's blood pressure is influenced by their own as well as their partner's reports of chronic stress and whether there are gender differences in these patterns.

8 Apr 2015

TOAST classification remains effective, easy-to-use system to classify strokes

In 1993, neurologists Harold P. Adams Jr., MD, and Jose Biller, MD, and colleagues proposed a new way to classify strokes. It became known as the TOAST classification. Twenty-two years later, the TOAST classification remains an effective and easy-to-use system that is routinely employed in stroke studies around the world, Drs. Adams and Biller report in the journal Stroke, published online ahead of print.

8 Apr 2015

Northwestern University researchers find safer way to improve surgery outcomes

A Northwestern University research team potentially has found a safer way to keep blood vessels healthy during and after surgery.

7 Apr 2015

New blood test may more accurately identify biomarkers for Parkinson's disease

A new blood test may more accurately identify blood signatures, or biomarkers, for Parkinson's disease (PD), according to a new study published in the journal Movement Disorders.

7 Apr 2015

Blood News and Research

Phase 2 IMAGO trial of SHP625 fails to meet primary endpoints in pediatric patients with ALGS

New study describes economic consequences of using T2Candida Panel for detection of candidemia

Diet rich in high glucoraphanin broccoli reduces blood LDL-cholesterol levels by around 6%

TABS study: Older people can improve their health by reducing sitting time

UTMB scientists develop quick-acting vaccine that is effective against Ebola strain

Study: Standard nursing assessments may help improve outcomes in cirrhosis patients

Changes in height can affect risk of coronary heart disease

Prolong Pharmaceuticals' SANGUINATE granted FDA Orphan Drug Designation for SCD treatment

TSRI scientists find molecular trigger of schizophrenia-like behaviors and brain changes

New simeprevir clinical data to be presented at EASL's International Liver Congress 2015

Scientists identify brain molecule that triggers schizophrenia-like behaviors, brain changes

CUMC researchers identify cellular defect that could lead to potential new treatment for diabetes

New study could point to potential ways to address defects in learning, memory

Two case studies provide potential new avenue for treatment of kidney cancer

Study identifies gut immune system as new, effective target for diabetes

Research finding may lead to new potential therapeutic targets for lung cancer

Researchers assess how chronic stress and relationship quality influence individual's blood pressure

TOAST classification remains effective, easy-to-use system to classify strokes

Northwestern University researchers find safer way to improve surgery outcomes

New blood test may more accurately identify biomarkers for Parkinson's disease

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

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