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Novel technology could improve diagnosis of peripheral arterial disease

Approximately 8 to 12 million people in the United States alone are suffering from peripheral arterial disease (PAD), a common vascular problem that is caused by narrowing of the arteries as a result of plaque buildup. The plaque accumulation leads to an insufficient blood flow to the body's extremities and increases a person's risk for heart attack and stroke by up to six times. PAD is also one of the most serious complications of diabetes.

26 Feb 2015

Tolero's alvocidib receives EMA orphan drug designation for treatment of AML patients

Tolero Pharmaceuticals, Inc., a clinical-stage company developing treatments for serious hematological diseases, today announced that the European Medicines Agency has granted orphan drug designation for alvocidib for the treatment of patients with acute myeloid leukemia (AML).

26 Feb 2015

Researchers reveal how malaria parasite deploys genetic trickery to escape immune system attack

Up to one million people -- mainly pregnant woman and young children -- are killed each year by the Plasmodium falciparum parasite, which causes the most devastating form of human malaria.

26 Feb 2015

Sanofi announces FDA approval of Toujeo insulin to improve glycemic control in people with diabetes

Sanofi announced today that the U.S. Food and Drug Administration approved Toujeo (insulin glargine [rDNA origin] injection, 300 U/mL), a once-daily long-acting basal insulin, to improve glycemic control in adults living with type 1 and type 2 diabetes. Toujeo is expected to be available in the U.S. at the beginning of Q2 2015.

26 Feb 2015

Beckman Coulter Genomics Introduces a Scalable RNA-seq service line for processing intact and degraded RNA samples

This fully automated sample preparation pipeline delivers consistent results run after run, reducing user variability and bias and allows processing of a large amount of samples with reduced turnaround time relative to manual library construction.

25 Feb 2015

Researchers generate mature, functional skeletal muscles using new approach

A team of researchers from Italy, Israel and the United Kingdom has succeeded in generating mature, functional skeletal muscles in mice using a new approach for tissue engineering. The scientists grew a leg muscle starting from engineered cells cultured in a dish to produce a graft.

25 Feb 2015

Researchers identify previously unknown effect of vitamin A in embryonic development

Researchers at Lund University in Sweden have identified a previously unknown effect of vitamin A in human embryonic development. Their findings show that vitamin A affects the formation of blood cells.

25 Feb 2015

Sotera Wireless announces acquisition of Reflectance Medical

Sotera Wireless, Inc. today announced its acquisition of Reflectance Medical Inc., a privately held company that has developed first-of-its kind technology aimed at detecting potentially life threatening conditions in critically ill patients, including those who have suffered trauma injuries.

25 Feb 2015

AR-V7 status does not affect response to taxane chemotherapy in patients with mCRPC

Findings from a small prospective study suggest that androgen receptor V7 (or AR-V7) status does not significantly affect response to taxane chemotherapy in men with metastatic castration-resistant prostate cancer (mCRPC). Treatment outcomes were largely similar for the 17 patients with AR-V7-positive prostate cancer and the 20 patients with AR-V7-negative disease included in this analysis.

25 Feb 2015

Sorafenib, sunitinib provide no benefit to patients with locally advanced kidney cancer

Findings from a federally funded study suggest that patients with locally advanced kidney cancer should not be treated with either adjuvant (post-surgery) sorafenib or sunitinib. The average period to disease recurrence was similar between those who received sorafenib or sunitinib after surgery (5.6 years) and those treated with placebo (5.7 years).

25 Feb 2015

Scientists detect new molecule that contributes to development of liver fibrosis

Liver fibrosis, which is the progressive formation of scar tissue in the liver, is a massive medical problem. An estimated ten percent of the population is affected by liver fibrosis or its corresponding later stage, liver cirrhosis. A variety of causes can lead to liver fibrosis, the most widely recognized ones being alcohol consumption and virus-induced chronic liver inflammation.

25 Feb 2015

Study finds new approaches to manage anticoagulant-associated intracerebral hemorrhage

Among patients with oral anticoagulation-associated intracerebral hemorrhage (bleeding within the brain), reversal of international normalized ratio (INR; a measure used to determine the clotting tendency of blood while on medication) below a certain level within 4 hours and systolic blood pressure less than 160 mm Hg at 4 hours were associated with lower rates of hematoma (a localized swelling filled with blood) enlargement, and resumption of anticoagulant therapy was associated with a lower risk of ischemic events without increased bleeding complications, according to a study in the February 24 issue of JAMA.

25 Feb 2015

Discovery demonstrates effect of exercise to prevent chronic health conditions

A researcher at the University of Virginia School of Medicine has magnified a benefit of exercise in mice to provide a "profound" protection from diabetic cardiomyopathy, a potentially deadly heart condition that affects many people with diabetes. The discovery demonstrates the power of exercise to prevent chronic health conditions and suggests that one day some benefits of exercise may come in a pill or bottle.

25 Feb 2015

Investigators define prevalence, associated factors for vasospasm in children with brain injuries

Vasospasm, or severe narrowing of blood vessels, is a dangerous complication observed in children with moderate to severe traumatic brain injury. In a paper recently published in Critical Care Medicine, investigators at Nationwide Children's Hospital have further defined the prevalence, associated factors and time course for vasospasm in children with these brain injuries.

25 Feb 2015

Reslizumab drug appears to reduce risk of severe asthma attacks

An investigational drug appears to cut the risk of severe asthma attacks in half for patients who have difficulty controlling the disorder with standard medications, according to results from two multicenter clinical trials.

25 Feb 2015

Simple paper strip test can rapidly diagnose Ebola

When diagnosing a case of Ebola, time is of the essence. However, existing diagnostic tests take at least a day or two to yield results, preventing health care workers from quickly determining whether a patient needs immediate treatment and isolation.

25 Feb 2015

Teen girls from rural areas have undiagnosed asthma, face higher risk of depression

Teen girls who live in rural areas are more likely than their male counterparts to have undiagnosed asthma, and they often are at a higher risk of depression, according to researchers at the Medical College of Georgia at Georgia Regents University.

25 Feb 2015

Hormone therapy safe for transgender individuals, say BUSM researchers

In the most comprehensive review to date addressing the relative safety of hormone therapy for transgender persons, researchers from Boston University School of Medicine have found that hormone therapy in transgender adults is safe. The findings, which appear in the Journal of Clinical and Translational Endocrinology, may help reduce the barriers for transgender individuals to receive medical care.

25 Feb 2015

Study shows how financial incentives can influence some HIV-positive patients in clinical settings

A new study by the HIV Prevention Trials Network shows that some HIV-positive patients were motivated by financial incentives to take their HIV antiretroviral therapy (ART) medication regularly and maintain control of their HIV - enhancing their own health benefits and reducing the chance of passing the virus on to others.

25 Feb 2015

Changes to DNA sequence associated with peanut allergy

Research funded by the National Institutes of Health suggests that changes in a small region of chromosome 6 are risk factors for peanut allergy in U.S. children of European descent. The genetic risk area is located among two tightly linked genes that regulate the presentation of allergens and microbial products to the immune system. This study is the first to use a genome-wide screening approach in patients with well-defined food allergy to identify risks for peanut allergy.

25 Feb 2015

Blood News and Research

Novel technology could improve diagnosis of peripheral arterial disease

Tolero's alvocidib receives EMA orphan drug designation for treatment of AML patients

Researchers reveal how malaria parasite deploys genetic trickery to escape immune system attack

Sanofi announces FDA approval of Toujeo insulin to improve glycemic control in people with diabetes

Beckman Coulter Genomics Introduces a Scalable RNA-seq service line for processing intact and degraded RNA samples

Researchers generate mature, functional skeletal muscles using new approach

Researchers identify previously unknown effect of vitamin A in embryonic development

Sotera Wireless announces acquisition of Reflectance Medical

AR-V7 status does not affect response to taxane chemotherapy in patients with mCRPC

Sorafenib, sunitinib provide no benefit to patients with locally advanced kidney cancer

Scientists detect new molecule that contributes to development of liver fibrosis

Study finds new approaches to manage anticoagulant-associated intracerebral hemorrhage

Discovery demonstrates effect of exercise to prevent chronic health conditions

Investigators define prevalence, associated factors for vasospasm in children with brain injuries

Reslizumab drug appears to reduce risk of severe asthma attacks

Simple paper strip test can rapidly diagnose Ebola

Teen girls from rural areas have undiagnosed asthma, face higher risk of depression

Hormone therapy safe for transgender individuals, say BUSM researchers

Study shows how financial incentives can influence some HIV-positive patients in clinical settings

Changes to DNA sequence associated with peanut allergy

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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