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Queen's University leads world's first trial of new combination treatment for advanced prostate cancer

Queen's University Belfast, in partnership with the Belfast Trust, is leading the world's first ever trial of a new combination of cancer therapies for patients with advanced prostate cancer, with the hope of prolonging their lives.

26 Feb 2016

Researchers unravel biochemical action of antimalarial drug

Malaria is a worldwide menace. According to the Centers for Disease Control and Prevention, over 500,000 individuals died from malaria in 2013 alone. While treatments for the disease exist, cures can also take a hefty physical toll.

26 Feb 2016

Major breakthrough opens door to better understanding of molecular mechanisms of pancreatic cancer

Pancreatic cancer carries a very bleak prognosis for patients. However, a recent breakthrough by two research teams, including one at the Hôpital Maisonneuve-Rosemont (CIUSSS-EST, Montreal) and University of Montreal, has opened the door to a better understanding of the molecular mechanisms that cause this cancer to develop.

26 Feb 2016

Researchers map cellular pathway that may lead to treatments for obesity, diabetes

Control over obesity and diabetes may be one step closer thanks to a Hiroshima University study in fat tissue.

26 Feb 2016

New analytical tool may help diagnose cancer faster than conventional methods

Researchers have developed a new analytical tool for medical applications and biological research that might be used to diagnose cancer more rapidly than conventional methods.

26 Feb 2016

Protein p62 acts as molecular brake to keep inflammation in check, avoid collateral damage

Inflammation is a Catch-22: the body needs it to eliminate invasive organisms and foreign irritants, but excessive inflammation can harm healthy cells, contributing to aging and sometimes leading to organ failure and death. Researchers at University of California, San Diego School of Medicine have discovered that a protein known as p62 acts as a molecular brake to keep inflammation in check and avoid collateral damage.

26 Feb 2016

Over-expression of heme oxygenase-1 enzyme protects the heart from doxorubicin damage

Life-threatening heart damage is an adverse side effect of the cancer drug doxorubicin, damage that also limits the use of newer chemotherapeutic agents such as trastuzumab and imatinib. The ability to protect the heart from these side effects would benefit patients, including cancer survivors who are at risk of developing heart damage years later, and it also could allow safer use of these drugs at higher doses.

26 Feb 2016

Research finding could lay foundation for more accurate diagnosis for rare childhood brain tumor

An international research team has identified four likely new subtypes of a rare brain tumor using molecular techniques that lay the foundation for more accurate diagnosis and tailored therapies for the hard-to-treat cancer. Scientists at St. Jude Children's Research Hospital and the German Cancer Research Center led the study, results of which appear today in the scientific journal Cell.

26 Feb 2016

Aggregated forms of transthyretin can trigger JIA development

Juvenile idiopathic arthritis (JIA) is a the most common form of arthritis in children and affects approximately 50,000 individuals in the United States alone. Previous research suggested that autoimmune responses cause JIA, but the specific antigens that are responsible for driving autoimmunity have not been identified.

26 Feb 2016

Allergan receives FDA approval to market ACZONE (dapsone) Gel, 7.5% for acne treatment

Allergan plc, a leading global pharmaceutical company, today announced that the Company has received approval from the U.S. Food and Drug Administration to market ACZONE (dapsone) Gel, 7.5%, a new prescription topical treatment for acne in patients 12 years of age and older.

26 Feb 2016

Clinical validation study on MaterniT GENOME test published in American Journal of Obstetrics and Gynecology

Sequenom, Inc., a life sciences company committed to enabling healthier lives through the development of innovative products and services, today announced the publication of a clinical validation study on the MaterniT GENOME laboratory-developed test in the American Journal of Obstetrics and Gynecology.

26 Feb 2016

Moffitt researchers develop novel therapeutic strategy to keep resistant cells in check

Despite numerous advances in oncology since the War on Cancer began, many patients develop resistance to standard therapies and eventually relapse. Moffitt Cancer Center researchers hope to improve treatment outcomes with development of a novel therapeutic strategy, called adaptive therapy, which is based on evolutionary principals and aims to keep resistant cells in check by maintaining a population of chemo-sensitive cells.

25 Feb 2016

UNC-Chapel Hill pharmacy researchers use skin cells to destroy brain tumors

In a first for medical science, University of North Carolina at Chapel Hill pharmacy researchers turn skin cells into cancer-hunting stem cells that destroy brain tumors known as glioblastoma - a discovery that can offer, for the first time in more than 30 years, a new and more effective treatment for the disease.

25 Feb 2016

Study provides pathways to understand complex neurological disorders

Scientists have now described the engineering of a bright red fluorescent protein-based voltage indicator, providing pathways to understanding complex neurological disorders. Designated as FlicR1 (fluorescent indicator for voltage imaging red), these indicators enable imaging of the electrical activity of many genetically targeted neurons with high spatial and temporal resolution.

25 Feb 2016

Maraviroc drug safe, well-tolerated when taken as PrEP to prevent HIV infection

Maraviroc, an oral drug used to treat HIV infection, is safe and well-tolerated when taken daily as pre-exposure prophylaxis (PrEP) to prevent HIV infection by HIV-uninfected men who have sex with men (MSM) at increased risk for acquiring HIV.

25 Feb 2016

New anti-ageing therapy may be effective against aplastic anaemia

Aplastic anaemia is a rare, and potentially fatal, disease of the blood, by which the bone marrow is unable to generate blood cells at the appropriate pace. Many forms of aplastic anaemia share an important link with the ageing process: the shortening of telomeres, structures that protect the ends of chromosomes.

25 Feb 2016

Researchers explore effects of attention bias modification in adolescents with MDD

A study to be published in the March 2016 issue of the Journal of the American Academy of Child and Adolescent Psychiatry reports that adolescents with major depression who performed a computer-based task designed to shift attention from sad to neutral to positive word associations showed reductions in negative attention biases and clinician-rated depressive symptoms.

25 Feb 2016

Researchers reveal how stress conditions favor lytic reactivation of herpesviruses

Hiding their DNA genome inside the nucleus of the infected cells, the herpesviruses establish a lifelong infection in humans. Not well defined stress conditions are known to wake up these parasites from their dormancy - the latent phase - and reactivate the production of new viral progeny, eventually causing cell death by lysis - the lytic phase.

25 Feb 2016

Scientists reveal underlying mechanism for formation and growth of epithelial tubes

A team of scientists from Singapore and France has revealed the underlying mechanism for the formation and growth of a fundamental type of tissue - epithelial tubes. Defects in the architecture of epithelial tubes lead to diseases such as cholestasis, atherosclerosis and polycystic kidney disease.

25 Feb 2016

Ground-breaking discovery could lead to new treatments for diabetes

Why would a bacteria-killing protein be present in an area of the body that is not normally exposed to bacteria, like the pancreas? Researchers at The Ottawa Hospital and the University of Ottawa puzzled over this question for some time, until they eventually discovered that the protein in question was doing something entirely unexpected - it was actually helping the pancreas regenerate and produce insulin.

25 Feb 2016

Cell News and Research

Queen's University leads world's first trial of new combination treatment for advanced prostate cancer

Researchers unravel biochemical action of antimalarial drug

Major breakthrough opens door to better understanding of molecular mechanisms of pancreatic cancer

Researchers map cellular pathway that may lead to treatments for obesity, diabetes

New analytical tool may help diagnose cancer faster than conventional methods

Protein p62 acts as molecular brake to keep inflammation in check, avoid collateral damage

Over-expression of heme oxygenase-1 enzyme protects the heart from doxorubicin damage

Research finding could lay foundation for more accurate diagnosis for rare childhood brain tumor

Aggregated forms of transthyretin can trigger JIA development

Allergan receives FDA approval to market ACZONE (dapsone) Gel, 7.5% for acne treatment

Clinical validation study on MaterniT GENOME test published in American Journal of Obstetrics and Gynecology

Moffitt researchers develop novel therapeutic strategy to keep resistant cells in check

UNC-Chapel Hill pharmacy researchers use skin cells to destroy brain tumors

Study provides pathways to understand complex neurological disorders

Maraviroc drug safe, well-tolerated when taken as PrEP to prevent HIV infection

New anti-ageing therapy may be effective against aplastic anaemia

Researchers explore effects of attention bias modification in adolescents with MDD

Researchers reveal how stress conditions favor lytic reactivation of herpesviruses

Scientists reveal underlying mechanism for formation and growth of epithelial tubes

Ground-breaking discovery could lead to new treatments for diabetes

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