Immune Response News and Research

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Potential transmission for Kawasaki disease unexpectedly uncovered due to COVID-19

Pandemic prevention measures have been associated with lower rates of Kawasaki disease in children across South Korea.

4 Jun 2021

How mass screening efforts have helped identify more cases of celiac disease in children

A new mass screening program of school-aged children in Italy found that the overall prevalence of celiac disease has almost doubled in the past 25 years.

4 Jun 2021

Methotrexate users fail to achieve adequate immune response to mRNA COVID-19 vaccines

Up to a third of patients taking methotrexate – a common treatment for immune mediated inflammatory conditions such as rheumatoid arthritis and psoriasis/psoriatic arthritis – failed to achieve an adequate immune response to mRNA COVID-19 vaccines in a small study accepted for publication in the journal Annals of the Rheumatic Diseases.

4 Jun 2021

Novel insights can open doors to combating clotting-related problems in COVID-19

Researchers scour what is known to come up with a hypothesis of why blood clots can be a major problem in COVID-19

4 Jun 2021

New biomaterial for pancreatic islet transplants does not trigger the body's immune response

A multidisciplinary research team led by Jonathan Lakey, Ph.D., professor of surgery and biomedical engineering at the University of California, Irvine, has developed a biomaterial for pancreatic islet transplants that doesn't trigger the body's immune response.

4 Jun 2021

Secondary infections amplify the brain's immune response and affect memory in Alzheimer's disease

New research into Alzheimer's disease (AD) suggests that secondary infections and new inflammatory events amplify the brain's immune response and affect memory in mice and in humans - even when these secondary events occur outside the brain.

3 Jun 2021

Alzheimer's disease increases a threefold risk of contracting severe COVID-19 and death

Neurodegenerative disorders that cause dementia increase the risk of contracting severe COVID-19 and dying from the disease.

3 Jun 2021

Heterologous AstraZeneca and Pfizer vaccines induce strong immune response and T cell reactivity against multiple SARS-CoV-2 variants

Researchers from Germany recently analyzed a cohort of 26 individuals in the age range of 25 to 46 (median 30.5) years who had received a ChAdOx1 nCoV-19 prime vaccine followed by a BNT162b2 boost vaccine after a 56-day interval due to changing vaccine recommendations in Germany. There were 16 females and 10 males in the cohort, and they were assessed for immune responses, reactogenicity, and T cell reactivity. This study is published on the medRxiv* preprint server.

3 Jun 2021

Study: Some Type 2 diabetes patients can benefit from bone marrow stem cell transplants

Type 2 diabetes patients who are not overweight and who have had the disorder for less than a decade can benefit from stromal stem cells transplanted from their own bone marrow, according to a study published today in STEM CELLS Translational Medicine.

3 Jun 2021

Researchers develop rapid antibody screening method for novel COVID-19 therapeutics development

New research undertaken by researchers in the USA describes two parallel but distinct in vivo approaches for the accelerated discovery of antibodies targeting SARS-CoV-2 spike protein.

3 Jun 2021

Study compares Pfizer and Moderna mRNA vaccine-elicited response to SARS-CoV-2 variants

A new study has been published on the bioRxiv preprint server which focuses on the correlation between the vaccine-triggered Immunoglobulin G (IgG) levels and neutralization titers against SARS-CoV-2 variants. Further, neutralization activities against the variants (B.1.1.7, B.1.525, and B.1.351), using Pfizer or Moderna vaccine, sera were assessed.

3 Jun 2021

SARS-CoV-2 exploits metal-dependent mechanism to evade immune surveillance

Scientists from The University of Texas Health Science Center at San Antonio have discovered a mechanism by which SARS-CoV-2 exploits changes in metal ion concentrations to disguise itself in the body. Varying concentrations of metal ions -- positively charged atoms such as magnesium, manganese and calcium -- are observed in hospitalized COVID-19 patients.

3 Jun 2021

Tiny implant reverses diabetes in mice without requiring drugs

A team of researchers led by diabetes specialists and biomedical engineers at Washington University School of Medicine in St. Louis and Cornell University has demonstrated that, using a miniscule device, they can implant insulin-secreting cells into diabetic mice.

3 Jun 2021

People taking anti-inflammatory drug mount a weaker immune response to COVID-19 vaccine

One-quarter of people who take the drug methotrexate for common immune system disorders -- from rheumatoid arthritis to multiple sclerosis -- mount a weaker immune response to a COVID-19 vaccine, a new study shows.

2 Jun 2021

E484K mutation may confer immune evasion capability on UK variant of SARS-CoV-2

A new medRxiv* preprint reports the immunomodulatory effect of the E484K mutation newly acquired by the United Kingdom (U.K.) variant.

2 Jun 2021

Large-scale expansion of spike-reactive T cells feasible after COVID-19 vaccination

A new bioRxiv* preprint reports on the successful use of a protocol to expand SARS-CoV-2-reactive T-cells a thousand-fold.

2 Jun 2021

New study sheds light on why many COVID-19 patients suffer from hypoxia

A new study published in the journal Stem Cell Reports by University of Alberta researchers is shedding light on why many COVID-19 patients, even those not in hospital, are suffering from hypoxia--a potentially dangerous condition in which there is decreased oxygenation in the body's tissues.

2 Jun 2021

Could higher carnitine levels in the blood protect against severe COVID-19?

Researchers at the MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK, found that carnitine and its derivative acetyl-carnitine provide a protective effect against severe COVID-19. Doubling of carnitine or acetyl-carnitine is tied to a 40-percent reduction risk of disease progression.

2 Jun 2021

BMI may not be best obesity indicator to evaluate lung cancer risk, study suggests

New research published in the Journal of Thoracic Oncology suggests the method used to calculate how obesity is measured may affect whether it is considered a risk factor for lung cancer.

2 Jun 2021

How antibody production in the lungs can determine severe respiratory infections

Recent findings describe how the presence of certain antibodies within the lungs can induce an immune response to minimize the effects of these infections.

2 Jun 2021

Immune Response News and Research

Potential transmission for Kawasaki disease unexpectedly uncovered due to COVID-19

How mass screening efforts have helped identify more cases of celiac disease in children

Methotrexate users fail to achieve adequate immune response to mRNA COVID-19 vaccines

Novel insights can open doors to combating clotting-related problems in COVID-19

New biomaterial for pancreatic islet transplants does not trigger the body's immune response

Secondary infections amplify the brain's immune response and affect memory in Alzheimer's disease

Alzheimer's disease increases a threefold risk of contracting severe COVID-19 and death

Heterologous AstraZeneca and Pfizer vaccines induce strong immune response and T cell reactivity against multiple SARS-CoV-2 variants

Study: Some Type 2 diabetes patients can benefit from bone marrow stem cell transplants

Researchers develop rapid antibody screening method for novel COVID-19 therapeutics development

Study compares Pfizer and Moderna mRNA vaccine-elicited response to SARS-CoV-2 variants

SARS-CoV-2 exploits metal-dependent mechanism to evade immune surveillance

Tiny implant reverses diabetes in mice without requiring drugs

People taking anti-inflammatory drug mount a weaker immune response to COVID-19 vaccine

E484K mutation may confer immune evasion capability on UK variant of SARS-CoV-2

Large-scale expansion of spike-reactive T cells feasible after COVID-19 vaccination

New study sheds light on why many COVID-19 patients suffer from hypoxia

Could higher carnitine levels in the blood protect against severe COVID-19?

BMI may not be best obesity indicator to evaluate lung cancer risk, study suggests

How antibody production in the lungs can determine severe respiratory infections

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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