RNA Sequencing News and Research

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Study may pave the way for mechano-medical approaches to treating abdominal aortic aneurysm

Abdominal aortic aneurysm (AAA) is a complex and life-threatening vascular disease with high incidence worldwide. Termed the silent killer, most AAAs are asymptomatic, often going undetected until rupture, and involve a poorly understood set of mechanical and biochemical events.

28 Jan 2022

Living human breast milk cells offer insight into breast cancer development

Researchers have explored the cellular changes that occur in human mammary tissue in lactating and non-lactating women, offering insight into the relationship between pregnancy, lactation, and breast cancer.

28 Jan 2022

Predicting pregnancy health and preeclampsia risk with blood RNA sequencing

In this interview, News-Medical speaks to Dr. Thomas McElrath about his latest research into a maternal-fetal medicine technique for predicting pregnancy health.

27 Jan 2022

Characterization of unique pathogenesis of SARS-CoV-2 Delta variant in mouse model

Researchers have investigated the pathology and inflammatory response to the Delta variant in mice.

24 Jan 2022

Researchers find ELF5 gene a leading candidate behind severe COVID-19

Are there any risk factors that predispose patients to severe COVID-19 outcomes? A recent study published in the medRxiv* preprint server sheds light on this popular question. Using a combination of population genetics to single-cell RNA sequencing, European researchers identified the respiratory epithelial cell-specific ELF5 gene as a potential mediator for severe COVID-19 cases.

24 Jan 2022

Researchers develop new biological parts to shape the flow of cellular processes along DNA

Scientists at the University of Bristol have developed new biological parts that are able to shape the flow of cellular processes along DNA.

21 Jan 2022

Recombinant bat coronavirus reported in wide-ranging Cambodian bat

A new study reports on the detection of recombinant coronaviruses in several bat species in Cambodia and of a related species in China.

20 Jan 2022

New genomic signature can spot aggressive tumor cells from primary, untreated prostate cancers

Many cases of early prostate cancer are dominated by cells that are slow-growing, often leading to a clinical decision to monitor for progression before initiating treatments that can have adverse side effects.

18 Jan 2022

Direct effect of SARS-CoV-2 on the kidney

Researchers infected human-induced pluripotent-stem-cell (iPSC)-derived kidney organoids with SARS-CoV-2 to study the virus's direct effect on the kidney.

18 Jan 2022

Similarities and dissimilarities in immune responses and metabolism in SARS-CoV-2 and HIV-1 infections

A new study, posted to the bioRxiv* preprint server, has developed a single-cell atlas that presents the shared and distinct immune responses and metabolism following SARS-CoV-2 and HIV-1 infections.

13 Jan 2022

Investigating the presence of human rRNA in the SARS-CoV-2 genome

In a new study, a team of researchers investigated the existence of SARS-CoV-2-host chimeric RNA and described two novel human-derived genomic insertions present in the circulating variants of SARS-CoV-2.

13 Jan 2022

Unraveling the early host-immune response to SARS-CoV-2 in mild COVID-19 infections

In a new study, researchers determined the early immune response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) during mild coronavirus disease 2019 (COVID-19) in rhesus macaques.

11 Jan 2022

Researchers set the framework for improved colorectal cancer surveillance using precision medicine

A team of Vanderbilt researchers has revealed some of the mechanisms by which polyps develop into colorectal cancer, setting the framework for improved surveillance for the cancer utilizing precision medicine.

7 Jan 2022

Researchers investigate SARS-CoV-2 specific inflammatory response

New research can confirm that while some of the response from monocytes to SARS-CoV-2 is generic to virus infection, most of it SARS-CoV-2 specific, especially proinflammatory responses.

7 Jan 2022

Exploring why children have milder COVID-19 infections compared to adults

A new study has revealed that an activated pre-exposure innate interferon response in airways together with significantly reduced systemic interferon-stimulated populations are associated with relatively milder severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children.

23 Dec 2021

Lung memory B-cells provide primary protection against SARS-CoV-2 reinfection

Researchers study influenza and SARS-CoV-2 infection models to identify lung memory B cells during viral infection.

20 Dec 2021

Long-read RNA sequencing identifies important host immune responses during SARS-CoV-2 infection

Researchers conduct a comprehensive in vitro analysis of relatively unexplored host immune responses during SARS-CoV-2 infection.

20 Dec 2021

Impact of acute kidney injury associated gene expression in human kidney cells

A new study attempts to perform a comparative single-cell census of human kidneys employing samples from individuals suffering from acute kidney injury and controls without the condition.

20 Dec 2021

Using fungal vaccine to train stem cells and enhance immune response to infections

The research group Immunology of Fungal Infections at the University of Valencia (UV) has investigated a fungal vaccine with which to train stem cells and hematopoietic progenitors (which produce all the cells of the blood and lifelong immune system) to improve the immune response to infections. The work has been published in the journal Frontiers in Immunology.

16 Dec 2021

Bioinformatics pipeline can be used to quickly identify SARS-CoV-2 therapeutics

In a new study, researchers developed a bioinformatics pipeline that uses RNA sequencing data to identify altered genes and signaling pathways affected by viral infection.

13 Dec 2021

RNA Sequencing News and Research

Study may pave the way for mechano-medical approaches to treating abdominal aortic aneurysm

Living human breast milk cells offer insight into breast cancer development

Predicting pregnancy health and preeclampsia risk with blood RNA sequencing

Characterization of unique pathogenesis of SARS-CoV-2 Delta variant in mouse model

Researchers find ELF5 gene a leading candidate behind severe COVID-19

Researchers develop new biological parts to shape the flow of cellular processes along DNA

Recombinant bat coronavirus reported in wide-ranging Cambodian bat

New genomic signature can spot aggressive tumor cells from primary, untreated prostate cancers

Direct effect of SARS-CoV-2 on the kidney

Similarities and dissimilarities in immune responses and metabolism in SARS-CoV-2 and HIV-1 infections

Investigating the presence of human rRNA in the SARS-CoV-2 genome

Unraveling the early host-immune response to SARS-CoV-2 in mild COVID-19 infections

Researchers set the framework for improved colorectal cancer surveillance using precision medicine

Researchers investigate SARS-CoV-2 specific inflammatory response

Exploring why children have milder COVID-19 infections compared to adults

Lung memory B-cells provide primary protection against SARS-CoV-2 reinfection

Long-read RNA sequencing identifies important host immune responses during SARS-CoV-2 infection

Impact of acute kidney injury associated gene expression in human kidney cells

Using fungal vaccine to train stem cells and enhance immune response to infections

Bioinformatics pipeline can be used to quickly identify SARS-CoV-2 therapeutics

Sequencing & Genomics: Elevating Science and Healthcare eBook

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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