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Study reveals a mechanism for mitochondrial activation via nucleoid dynamics

Mitochondria, famously known as the powerhouse of the cell, are important cellular structures that are vital for their role of generating energy. Mitochondria are "dynamic", meaning they constantly fuse together and split apart. They contain a small amount of genetic information known as mitochondrial DNA (mtDNA).

17 Nov 2022

Extensive time in early center-based child care does not cause behavior problems, study finds

Previous research indicates that extensive time in early center-based day care is correlated with high levels of behavior problems in young children. However, the validity of this work has been controversial and its relevance outside of the United States has been called into question.

17 Nov 2022

Potential effects of nonoral versus oral gender-affirming estrogen therapy

A comprehensive review of research into the delivery method of estrogen treatment (e.g., oral, intramuscular injection, transdermal patch, etc.) and cardiovascular risk in transgender women and gender-diverse people found that treatment route may affect heart health, but there is not enough available data for metanalysis. The study is published ahead of print in the American Journal of Physiology-Heart and Circulatory Physiology. It was chosen as an APSselect article for November.

17 Nov 2022

National Institutes of Health funds a five-year, $11 million initiative

The conversations between our bone and muscle change as we age, and both are the weaker for it, Medical College of Georgia scientists say.

17 Nov 2022

Augmented drug preferentially eliminates cancer cells but does not harm healthy cells

Johns Hopkins Medicine researchers have revamped an anti-cancer drug to better target cancer cells and leave healthy tissues unharmed. Scientists have dubbed this type of targeted approach a "prodrug" - a medicine designed to release its payload in a particular area of the body and in no other areas.

17 Nov 2022

Research highlights an understudied aspect of Alzheimer’s disease

Memory loss is often the first sign of Alzheimer's disease, followed by confusion and difficulty thinking. These symptoms reflect the typical pattern of worsening damage to brain tissues. Toxic clusters of proteins first concentrate in the temporal lobes of the brain - the memory area - before spreading to parts of the brain important for thinking and planning.

17 Nov 2022

Study finds a lower compliance rate with recently released guidelines for COVID-19 care

Uptake of national guidelines for the treatment of children hospitalized with COVID-19 fell well below what would typically be expected, report researchers at the Medical University of South Carolina (MUSC) and elsewhere in Pediatrics.

17 Nov 2022

Inhibitory neuron dysfunction emerges as a modulable mechanism of hyperexcitability

A small group of brain cells linked in a circuit is responsible for setting off whole-brain seizures in a rare form of epilepsy affected by blood sugar levels, a study led by UT Southwestern researchers suggests. The finding, published in Science Translational Medicine, could lead to new treatments for other metabolic disorders in the brain, the authors said.

17 Nov 2022

Jynneos vaccine for Monkeypox not linked to hospitalization, serious cardiac events

In a recent study posted to the medRxiv* preprint server, researchers investigated the incidence of cardiac AESIs (adverse events of special interest) among Kaiser Permanente Northwest (KPNW) members who had received JYNNEOS vaccinations against the monkeypox (MPX) virus.

16 Nov 2022

Mothers of younger or multiple children may engage in lower amounts of physical activity

A new study exploring physical activity patterns among mothers in Britain suggests that mothers of young children and mothers of multiple children may engage in lower amounts of moderate or vigorous physical activity.

16 Nov 2022

Modified CEUS criteria using perfluorobutane can help diagnose high-risk hepatocellular carcinoma

According to an accepted manuscript published in ARRS' American Journal of Roentgenology (AJR), diagnostic performance of LR-5 for hepatocellular carcinoma (HCC) diagnosis was not significantly different between modified contrast-enhanced ultrasound (CEUS) using perfluorobutane and CT/MRI LI-RADS version 2018.

16 Nov 2022

Whole genome sequencing could help to reduce the spread of drug-resistant bacteria in hospitals

The spread of antibiotic-resistant bacteria in hospitals could be greatly reduced thanks to research by The University of Queensland and Queensland Health.

16 Nov 2022

Researchers discover the mechanism for heart complications from immune checkpoint inhibitors

Myocarditis is a complication that can occur in cancer patients treated with immune checkpoint inhibitors.

16 Nov 2022

Key Alzheimer’s gene alters the way cholesterol moves around the brain, research finds

A gene recognized as the strongest risk factor for Alzheimer's disease (AD) alters the way cholesterol moves around the brain and as we age, this altered movement likely contributes to loss of learning and memory, a team of researchers from the Icahn School of Medicine at Mount Sinai and the Massachusetts Institute of Technology reports.

16 Nov 2022

ADHD drug associated with lowest risk of amphetamine-related hospitalizations and death

The ADHD medication lisdexamfetamine was associated with the lowest risk of hospitalization and death in people with amphetamine addiction, when medications generally used among persons with substance use disorders were compared.

16 Nov 2022

Study explores how corporal punishment may impact neural systems to produce adverse effects

Don't spank your kids. That's the conventional wisdom that has emerged from decades of research linking corporal punishment to a decline in adolescent health and negative effects on behavior, including an increased risk for anxiety and depression.

16 Nov 2022

Amyloid-PET scanning has misled the FDA into granting approval for Aduhelm

Last year, the FDA gave accelerated approval of the antibody aducanumab (marketed as Aduhelm by Biogen) for the treatment of Alzheimer's disease.

16 Nov 2022

Antibiotic-resistant, opportunistic pathogen enhances the pathogenesis of C. difficile

Clostridioides difficile, often referred to as C. difficile or C. diff, is a bacterium that causes severe intestinal illness and, as its name suggests, can be difficult to study and treat.

16 Nov 2022

Collaborative project focuses on improving access to breast cancer care in Argentina

The National Comprehensive Cancer Network- a non-profit alliance of leading cancer centers across the United States - is launching a collaborative project with the Latin American and Caribbean Society of Medical Oncology in Buenos Aires, Argentina, today.

16 Nov 2022

Colleagues can encourage employees' healthy eating behavior

Scientists from Cologne and Utrecht have found that employees are more likely to eat fruit and vegetables as well as engage in physical activity when their colleagues encourage a healthy lifestyle.

16 Nov 2022

Research News and Research

Study reveals a mechanism for mitochondrial activation via nucleoid dynamics

Extensive time in early center-based child care does not cause behavior problems, study finds

Potential effects of nonoral versus oral gender-affirming estrogen therapy

National Institutes of Health funds a five-year, $11 million initiative

Augmented drug preferentially eliminates cancer cells but does not harm healthy cells

Research highlights an understudied aspect of Alzheimer’s disease

Study finds a lower compliance rate with recently released guidelines for COVID-19 care

Inhibitory neuron dysfunction emerges as a modulable mechanism of hyperexcitability

Jynneos vaccine for Monkeypox not linked to hospitalization, serious cardiac events

Mothers of younger or multiple children may engage in lower amounts of physical activity

Modified CEUS criteria using perfluorobutane can help diagnose high-risk hepatocellular carcinoma

Whole genome sequencing could help to reduce the spread of drug-resistant bacteria in hospitals

Researchers discover the mechanism for heart complications from immune checkpoint inhibitors

Key Alzheimer’s gene alters the way cholesterol moves around the brain, research finds

ADHD drug associated with lowest risk of amphetamine-related hospitalizations and death

Study explores how corporal punishment may impact neural systems to produce adverse effects

Amyloid-PET scanning has misled the FDA into granting approval for Aduhelm

Antibiotic-resistant, opportunistic pathogen enhances the pathogenesis of C. difficile

Collaborative project focuses on improving access to breast cancer care in Argentina

Colleagues can encourage employees' healthy eating behavior

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