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Researchers one step closer to development of drug-eluting contact lens for glaucoma treatment

For nearly half a century, contact lenses have been proposed as a means of ocular drug delivery that may someday replace eye drops, but achieving controlled drug release has been a significant challenge. Researchers at Massachusetts Eye and Ear/Harvard Medical School Department of Ophthalmology, Boston Children's Hospital, and the Massachusetts Institute of Technology are one step closer to an eye drop-free reality with the development of a drug-eluting contact lens designed for prolonged delivery of latanoprost, a common drug used for the treatment of glaucoma, the leading cause of irreversible blindness worldwide.

9 Dec 2013

Gecko Biomedical announces closing of Series A financing round

Gecko Biomedical, a privately owned medical device company based in Paris that is developing novel biodegradable surgical wound closure solutions, announced the closing of a €8 million ($11m) Series A financing round. The financing was co-led by Omnes Capital and CM-CIC Capital Finance, and joined by CapDecisif Management.

9 Dec 2013

New form of gene therapy shows promising outcomes for "bubble boy" disease

Researchers reported promising outcomes data for the first group of boys with X-linked severe combined immunodeficiency syndrome (SCID-X1), a fatal genetic immunodeficiency also known as "bubble boy" disease, who were treated as part of an international clinical study of a new form of gene therapy. The mechanism used to deliver the gene therapy is designed to prevent the serious complication of leukemia that arose a decade ago in a similar trial in Europe, when one-quarter of boys treated developed the blood cancer.

9 Dec 2013

Genetically engineered cell therapies demonstrate early efficacy, safety in patients with blood disorders

A series of advancements in genetically engineered cell therapies demonstrate early efficacy and safety in patients with blood disorders for whom standard treatments have been unsuccessful, according to data showcased today during the 55th American Society of Hematology (ASH) Annual Meeting and Exposition in New Orleans.

9 Dec 2013

State highlights: N.C. panel finds Medicaid costs may not stabilize until 2020; Va. readies new mental health changes

State health policy stories from North Carolina and Virginia.

9 Dec 2013

Every hour, every day a child is taken to a hospital as injuries surge 22 percent

High chairs and booster seats are commonly used to help make feeding young children easier. Although most parents assume these products are safe, millions have been recalled in recent years, and injuries associated with their use continue to occur.

9 Dec 2013

Viewpoints: Health law is here to stay; problems for Obamacare go beyond website; future 'doc shock'

For almost two months, the debacle of healthcare.gov allowed conservatives to live the life they always wanted. Health reform was a dismal failure; Obama would go down in history as a laughingstock; government can't do anything; viva Ayn Rand! ... while things are far from completely fixed, the crisis is clearly over. Obamacare will have millions of beneficiaries by the time open enrollment ends; it will add many more in the 2015 cycle. Health reform is pretty much irreversible at this point (Paul Krugman, 12/5).

9 Dec 2013

$Management of refractory convulsive status epilepticus varies at different medical centers$

Management of refractory convulsive status epilepticus varies at different medical centers

The management of refractory convulsive status epilepticus varies at different medical centers and from patient to patient. Rapid success in aborting these non-stop seizures is crucial as the risk of neurological damage is high and, though rare, may result in death depending on seizure duration. By pooling data and analyzing current RCSE management practices, researchers representing a multicenter network of tertiary referral hospitals in the U.S. conducted a study that could lead to improved treatment outcomes for potentially life-threatening seizures.

9 Dec 2013

MRI-guided SLA surgery proves safe and shows adequate efficacy for seizure control

MRI-Guided Stereotactic Laser Ablation of the hippocampus to control seizures in people with temporal lobe epilepsy may result in seizure control that approaches that from anterior temporal lobectory or selective amygdalohippocampectomy and better cognitive outcomes than any of the standard open resections, according to a study presented at the American Epilepsy Society's 67th Annual Meeting in Washington DC.

9 Dec 2013

Majority of epilepsy surgery patients satisfied with results in improving psychological and social well-being

The majority of epilepsy patients who have brain surgery to treat their disorder are satisfied with the results in reducing epilepsy-related seizures and improving their psychological and social well-being.

9 Dec 2013

Research roundup: 'Substantial' Medicare savings from avoiding ERs; new ways for primary care; trends in kids' fast food consumption

Some Medicare beneficiaries who place 911 calls to request an ambulance might safely be cared for in settings other than the emergency department at lower cost. Using 2005–09 Medicare claims data and a validated algorithm, we estimated that 12.9–16.2 percent of Medicare-covered 911 emergency medical services transports involved conditions that were probably nonemergent or primary care treatable.

9 Dec 2013

Study: Uncontrolled epilepsy associated with higher healthcare utilization

Seizures in people with epilepsy are commonly treated with anti-epileptic drugs (AEDs) but 30-40 percent do not achieve adequate seizure control, predisposing them to severe health risks, impaired quality of life and higher healthcare costs.

9 Dec 2013

Low-income women less likely to receive breast cancer treatment

Women with interruptions in health insurance coverage or with low income levels had a significantly increased likelihood of failing to receive breast cancer care that is in concordance with recommended treatment guidelines, according to results presented here at the Sixth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held Dec. 6-9.

9 Dec 2013

Researchers investigate effect of epilepsy surgery on patients lives

Resective surgery is an effective treatment for dug-resistant epilepsy. To investigate the effect of epilepsy surgery on patients lives, researchers from the Comprehensive Epilepsy Program at the Henry Ford Hospital in Detroit conducted a long-term retrospective follow up of surgical patients and correlated post-surgical psychosocial outcomes with seizure outcome and brain area surgically treated.

9 Dec 2013

Nurses bring fresh perspective to caring for troubled teens, Saint Louis U researcher finds

Psychiatric nurses offer a missing and critical point of view in treating adolescents in foster care who have mental health issues, an instructor at Saint Louis University School of Nursing found.

9 Dec 2013

Study helps explain why survival gap persists for African-Americans with head and neck cancer

A team of scientists at Johns Hopkins and in Texas has identified a handful of genetic mutations in black Americans, in addition to some chemical alterations affecting gene activity, which may help explain why the death rate among African-Americans from the most common form of head and neck cancer continues to hover some 18 percent higher above the death rate of whites with the same cancer.

9 Dec 2013

Increased levels of protein HSET linked with worse breast cancer outcomes in African-Americans

Among African-American women with breast cancer, increased levels of the protein HSET were associated with worse breast cancer outcomes, according to results presented here at the Sixth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held Dec. 6-9.

9 Dec 2013

UCSF awarded $9.45M federal grant to transform, revolutionize treatment of prostate cancer

UC San Francisco has been awarded a major federal grant to "transform and revolutionize" the treatment of prostate cancer, the second most common form of cancer among American men.

9 Dec 2013

Downregulation of caveolin-1 contributes to synaptic plasticity deficit in hippocampus of aged rats

Caveolin-1 may be a new target for interfering with age-dependent decline in synaptic plasticity. To explore the relationship between synaptic plasticity in the aging process and changes in learning and memory, Dr. Yang Liu and coworkers from the First Affiliated Hospital, Dalian Medical University, China examined synaptophysin expression in the hippocampus, cortex and cerebellum of rats at different ages, and analyzed the association between synaptophysin expression and cognition and behaviors.

9 Dec 2013

Gemtuzumab with standard chemotherapy can reduce risk of relapse in pediatric patients with AML

The addition of a monoclonal antibody called gemtuzumab combined with standard chemotherapy has been shown to significantly reduce the risk of relapse and increase rates of disease-free survival in pediatric patients with acute myeloid leukemia (AML).

9 Dec 2013

Hospital News and Research

Researchers one step closer to development of drug-eluting contact lens for glaucoma treatment

Gecko Biomedical announces closing of Series A financing round

New form of gene therapy shows promising outcomes for "bubble boy" disease

Genetically engineered cell therapies demonstrate early efficacy, safety in patients with blood disorders

State highlights: N.C. panel finds Medicaid costs may not stabilize until 2020; Va. readies new mental health changes

Every hour, every day a child is taken to a hospital as injuries surge 22 percent

Viewpoints: Health law is here to stay; problems for Obamacare go beyond website; future 'doc shock'

Management of refractory convulsive status epilepticus varies at different medical centers

MRI-guided SLA surgery proves safe and shows adequate efficacy for seizure control

Majority of epilepsy surgery patients satisfied with results in improving psychological and social well-being

Research roundup: 'Substantial' Medicare savings from avoiding ERs; new ways for primary care; trends in kids' fast food consumption

Study: Uncontrolled epilepsy associated with higher healthcare utilization

Low-income women less likely to receive breast cancer treatment

Researchers investigate effect of epilepsy surgery on patients lives

Nurses bring fresh perspective to caring for troubled teens, Saint Louis U researcher finds

Study helps explain why survival gap persists for African-Americans with head and neck cancer

Increased levels of protein HSET linked with worse breast cancer outcomes in African-Americans

UCSF awarded $9.45M federal grant to transform, revolutionize treatment of prostate cancer

Downregulation of caveolin-1 contributes to synaptic plasticity deficit in hippocampus of aged rats

Gemtuzumab with standard chemotherapy can reduce risk of relapse in pediatric patients with AML

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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