Immune Response News and Research

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Study uncovers role for STING in regulating tumor response to DNA-damaging treatments

In a study by Yale Cancer Center, researchers report on the discovery of a new role for STimulator of INterferon Genes or STING.

19 Apr 2021

Just one mRNA vaccine dose sufficient for people with prior SARS-CoV-2 infection

A small study, previously posted to the medRiv preprint server in early March, was recently published in the journal Science Immunology. The now peer-reviewed research led by E. John Wherry of the University of Pennsylvania Perelman School of Medicine finds people previously exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produced a more robust immune response after receiving the first — but not the second mRNA vaccine.

19 Apr 2021

One dose of mRNA vaccine may be sufficient for individuals previously infected with SARS-CoV-2

A recent scientific report from Israel shows how healthcare workers previously infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) present with higher Immunoglobulin G (IgG) titers after receiving one dose of Pfizer–BioNTech COVID-19 vaccine in comparison to their fully vaccinated, never-infected counterparts. Conversely, the occurrence of post-vaccination infection does not increase IgG titers.

19 Apr 2021

New COVID-19 vaccine could provide protection against existing and future strains of coronaviruses

A COVID-19 vaccine that could provide protection against existing and future strains of the COVID-19 coronavirus, and other coronaviruses, and cost about $1 a dose has shown promising results in early animal testing.

19 Apr 2021

Researchers develop computational model to predict changes in SARS-CoV-2’s viral fitness

Two researchers from the Université Libre de Bruxelles in Belgium, Fabrizio Pucci and Marianne Rooman, recently built a simplified computational model, called SpikePro, to predict the SARS-CoV-2 fitness from the amino acid sequence and structure of the spike protein. This study focuses on the spike protein’s stability and the binding affinity to the host receptor.

19 Apr 2021

Study assess prevalence of SARS-CoV-2 in England after third national lockdown

In a new study, the REACT-1 research group offer their findings on the rate of SARS-CoV-2 infection in England after the country went into a third national lockdown. Their findings show a 60% reduction of incidence from their previous round of surveillance.

19 Apr 2021

Global scarcity of novel antibiotics drives the emergence and spread of antimicrobial resistance

The world is still failing to develop desperately needed antibacterial treatments, despite growing awareness of the urgent threat of antibiotic resistance, according to report by the World Health Organization. WHO reveals that none of the 43 antibiotics that are currently in clinical development sufficiently address the problem of drug resistance in the world's most dangerous bacteria.

19 Apr 2021

Obesity, hypertension and smoking linked to lower vaccine-induced antibody production against SARS-CoV-2

In a recent study posted to the medRxiv preprint server, a research group from Italy has demonstrated that the antibody response can be blunted in subjects with certain risk factors shortly after the second dose of mRNA vaccine against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

18 Apr 2021

Studies suggest mRNA COVID-19 vaccine may have reduced efficacy in patients with blood cancer

Two new studies published in Blood suggest that the mRNA COVID-19 vaccine may have reduced efficacy in individuals with chronic lymphocytic leukemia (CLL) and multiple myeloma, two types of blood cancer.

17 Apr 2021

Candidate coronavirus vaccines show promising results in early animal testing

A candidate vaccine that could provide protection against the COVID-19 virus and other coronaviruses has shown promising results in early animal testing.

17 Apr 2021

Ask KHN-Politifact: I’ve recovered from Covid. Why do i still have to mask up?

More than 120 million Americans have joined arguably the most sought-after club on Earth: those immunized against the coronavirus.

16 Apr 2021

Mysterious ailment, mysterious relief: Vaccines help some Covid long haulers

An estimated 10% to 30% of people who get Covid-19 suffer from lingering symptoms of the disease, or what’s known as “long Covid.”

16 Apr 2021

Numerous agents with anti-SARS-CoV-2 potential discovered with crystallographic screening

An international team of researchers focused on the macrodomain part of the non-structural protein 3 (Nsp3) gene product that SARS-CoV-2 uses to overturn the host cell’s natural antiviral response. The team provided a template that can help develop novel antivirals that are direct-acting and can combat the current pandemic.

16 Apr 2021

COVID-19 vaccination of lactating mothers elicits specific IgA antibodies in breast milk

A new study, released on the medRxiv* preprint server, examines the presence of SARS-CoV-2-specific IgA in human milk and its association with the protection of breastfed infants against the disease.

16 Apr 2021

Recovered COVID-19 patients may need only a single vaccine dose, suggests study

People who have recovered from COVID-19 had a robust antibody response after the first mRNA vaccine dose, but little immune benefit after the second dose, according to new research from the Penn Institute of Immunology. The findings, published today in Science Immunology, suggest only a single vaccine dose may be needed to produce a sufficient antibody response.

16 Apr 2021

Immune Response News and Research

Study uncovers role for STING in regulating tumor response to DNA-damaging treatments

Just one mRNA vaccine dose sufficient for people with prior SARS-CoV-2 infection

One dose of mRNA vaccine may be sufficient for individuals previously infected with SARS-CoV-2

New COVID-19 vaccine could provide protection against existing and future strains of coronaviruses

Researchers develop computational model to predict changes in SARS-CoV-2’s viral fitness

Study assess prevalence of SARS-CoV-2 in England after third national lockdown

Global scarcity of novel antibiotics drives the emergence and spread of antimicrobial resistance

Obesity, hypertension and smoking linked to lower vaccine-induced antibody production against SARS-CoV-2

Studies suggest mRNA COVID-19 vaccine may have reduced efficacy in patients with blood cancer

Candidate coronavirus vaccines show promising results in early animal testing

Ask KHN-Politifact: I’ve recovered from Covid. Why do i still have to mask up?

Mysterious ailment, mysterious relief: Vaccines help some Covid long haulers

Numerous agents with anti-SARS-CoV-2 potential discovered with crystallographic screening

COVID-19 vaccination of lactating mothers elicits specific IgA antibodies in breast milk

Recovered COVID-19 patients may need only a single vaccine dose, suggests study

Intestinal worm infection can cause severe sexually transmitted viral diseases

Study reveals new genes that program stem cells to make dendritic cells

COVID-19 vaccine INO-4800 shows efficacy against SARS-CoV-2 variants

Feline model of SARS-CoV-2 infection imitates COVID-19 in humans

New machine learning method for designing more effective antibody drugs

Understanding the DNA Damage Response in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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