Angiotensin Converting Enzyme 2 News and Research

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Interferon response induced by Omicron BA.1 and BA.5 prevents influenza A infection

In a recent study posted to the bioRxiv* preprint server, researchers in Germany and the United Kingdom investigated the interferon responses induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant and SARS-CoV-2 Omicron sub-variants BA.1 and BA.5, and their efficacy in protecting cells from influenza A virus super-infection.

12 Sep 2022

Discovery of antibodies that may eliminate the need for COVID vaccines

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11 Sep 2022

All SARS-CoV-2 variants neutralized by a potent new antibody

Researchers describe a mouse model used to generate a VH1-2 heavy chain (HC)- and Vκ1-33 light chain (LC)-based recombinant antibody that broadly neutralized all severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, including the newly emergent Omicron sub-variant BA.5.

9 Sep 2022

Can preclinical COVID-19 models help unlock mystery of long-COVID?

In a recently published article in the journal PLOS PATHOGENS, scientists have summarized acute and prolonged clinical manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The review also provides an overview of the potency and utility of preclinical animal models to understand the mechanistic details of acute and long coronavirus disease 2019 (COVID-19).

8 Sep 2022

Licorice compounds proposed as effective candidates for treatment of COVID-19

Researchers describe the different mechanisms by which licorice active ingredients target SARS-CoV-2.

8 Sep 2022

Biosynthetic proteins show promise as SARS-CoV-2 antivirals targeting spike protein

Researchers developed an αRep series specific to the RBD of the SARS-CoV-2 S, which could easily adapt to work stably against SARS-CoV-2 variants at a low cost.

8 Sep 2022

The role of some important antioxidants in major clinical outcomes of subjects with COVID-19

Researchers investigated the role of antioxidants such as selenium, zinc, α-lipoic acid, and vitamins A, E, D, and C in improving the clinical outcomes of COVID-19.

8 Sep 2022

How does SARS-CoV-2 infection and vaccination impact human immune memory?

Researchers review current knowledge regarding the generation of immune memory responses and their durability post-infection and vaccination.

7 Sep 2022

How does SARS-CoV-2 affect the male genitourinary system?

In a recent paper published in the American Journal of Clinical and Experimental Urology, researchers reviewed existing data on the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on the male genitourinary (GU) tract.

7 Sep 2022

How does SARS-CoV-2 infection impact fertility in men?

In a recent review published in the journal Endocrines, researchers summarized existing literature findings on the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on the male reproductive system and fertility.

7 Sep 2022

Plant production of nanobodies that neutralize the interaction between ACE2 receptor and SARS-CoV-2 spike protein

Researchers demonstrated the production of nanobodies against SARS-CoV-2 spike protein.

7 Sep 2022

Photocatalyst-based ViraMap platform maps SARS-CoV-2 spike protein interactions on the cell surface

Researchers performed the photocatalytic mapping of the SARS-CoV-2 spike protein-host cell membrane interactions.

7 Sep 2022

Study suggests entry of SARS-CoV-2 requires an acidic pH

Researchers carried out real-time single-virion tracking in three dimensions to study the mechanisms and requirements of membrane attachment and fusion of SARS-CoV-2 with the host cell.

6 Sep 2022

The possible association between SARS-CoV-2, ACE2, TMPRSS2, and skin manifestations

A new study analyzed the possibility of penetration of SARS-CoV-2 into the skin.

5 Sep 2022

How does ACE2 expression in target cells affect neutralization by antibodies to different spike epitopes?

Researchers evaluated how ACE2 expression in target cells impacts neutralization.

2 Sep 2022

A rapid and efficient method of identifying neutralizing nanobodies directed against SARS-CoV-2

A recent PLoS ONE study detected neutralizing nanobodies against SARS-CoV-2 from nanobody phage display libraries and via in vitro and ex vivo high-throughput screenings.

2 Sep 2022

N501Y mutation and SARS-CoV-2 spike protein-angiotensin-converting enzyme-2 binding

In a new study, researchers assessed the effects of N501Y mutation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein on binding to angiotensin-converting enzyme-2 (ACE-2).

1 Sep 2022

How effective was the Shanghai lockdown policy compared with that of other countries?

A recent study aimed to fill this gap in research by evaluating the impact of strict lockdown measures on SARS-CoV-2 Omicron transmission in Shanghai between March and April 2022.

31 Aug 2022

What is the infectivity of SARS-CoV-2 Omicron BA.2.75 variant?

Researchers recently assessed the infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.2.75 variant compared to preexisting variants.

30 Aug 2022

SARS-CoV-2 Omicron BA.2.75 replicates more efficiently than BA.2 or BA.5 sub-variants

In a new study, researchers characterized the clinical isolates of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.2.75 sub-variant.

30 Aug 2022

Angiotensin Converting Enzyme 2 News and Research

Interferon response induced by Omicron BA.1 and BA.5 prevents influenza A infection

Discovery of antibodies that may eliminate the need for COVID vaccines

All SARS-CoV-2 variants neutralized by a potent new antibody

Can preclinical COVID-19 models help unlock mystery of long-COVID?

Licorice compounds proposed as effective candidates for treatment of COVID-19

Biosynthetic proteins show promise as SARS-CoV-2 antivirals targeting spike protein

The role of some important antioxidants in major clinical outcomes of subjects with COVID-19

How does SARS-CoV-2 infection and vaccination impact human immune memory?

How does SARS-CoV-2 affect the male genitourinary system?

How does SARS-CoV-2 infection impact fertility in men?

Plant production of nanobodies that neutralize the interaction between ACE2 receptor and SARS-CoV-2 spike protein

Photocatalyst-based ViraMap platform maps SARS-CoV-2 spike protein interactions on the cell surface

Study suggests entry of SARS-CoV-2 requires an acidic pH

The possible association between SARS-CoV-2, ACE2, TMPRSS2, and skin manifestations

How does ACE2 expression in target cells affect neutralization by antibodies to different spike epitopes?

A rapid and efficient method of identifying neutralizing nanobodies directed against SARS-CoV-2

N501Y mutation and SARS-CoV-2 spike protein-angiotensin-converting enzyme-2 binding

How effective was the Shanghai lockdown policy compared with that of other countries?

What is the infectivity of SARS-CoV-2 Omicron BA.2.75 variant?

SARS-CoV-2 Omicron BA.2.75 replicates more efficiently than BA.2 or BA.5 sub-variants

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Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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