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Psychedelics may offer anxiety relief through specific brain circuits

New research suggests that it could be possible to separate treatment from hallucinations when developing new drugs based on psychedelics.

15 Nov 2024

New drug strategy reverses resistance to immunotherapy in pancreatic cancer

A new drug strategy that regulates the tumor immune microenvironment may transform a tumor that resists immunotherapy into a susceptible one, according to a study by researchers from the Johns Hopkins Kimmel Cancer Center and Oregon Health & Science University.

14 Nov 2024

Interactive atlas unveils immune changes in multiple myeloma

Multiple Myeloma (MM) is an incurable blood cancer, leading to weakened immunity, bone damage, and other serious health issues.

14 Nov 2024

Innovative urine test could improve pancreatic cancer survival rates

Innovative urinary miRNA profiling shows potential for early pancreatic cancer detection, with high accuracy and sensitivity, transforming screening practices.

14 Nov 2024

Rutgers study sheds light on how bedaquiline fights drug-resistant tuberculosis

Rutgers Health research has uncovered why a relatively new antibiotic for tuberculosis (TB) works against multidrug-resistant strains, potentially inspiring improved treatments and drug development strategies.

13 Nov 2024

Neuropeptides influence T cell differentiation during viral infections

T helper (TH) cells are essential immune cells that help other immune cells function effectively. When activated in response to environmental stimuli, these cells can differentiate into either TH1 cells, which fight against viruses and intracellular pathogens, or TH2 cells, which fight against extracellular pathogens like bacteria and parasites.

12 Nov 2024

Studies link gut dysbiosis to pancreatic cancer, offering pathways for early detection

The gut microbiome's impact on pancreatic cancer highlights potential for early screening and fecal microbiota transplantation in improving treatment efficacy.

11 Nov 2024

How gut bacteria regulate stress and sleep cycles

This study reveals that gut microbiota, particularly Lactobacillus species, regulate the daily rhythm of stress hormones like corticosterone, influencing stress responses and brain function at different times of the day. Disruptions in gut bacteria lead to altered stress responses and increased susceptibility to disorders like depression.

10 Nov 2024

Spatial transcriptomics uncovers tissue niches in multiple sclerosis

Mapping cell types in MS lesions reveals unique tissue niches and interactions, offering insights into the molecular drivers of multiple sclerosis progression.

8 Nov 2024

New biomarker could predict response to IBD treatment

Not everyone responds equally well to treatments for inflammatory bowel disease (IBD). What will work for individual patients involves trial and error during the treatment process.

7 Nov 2024

Copper accumulation linked to aggressive growth of kidney cancer

A new study led by University of Cincinnati Cancer Center researchers details how the accumulation of copper helps clear cell renal cell carcinoma (ccRCC) - the most common kidney cancer - grow and advance in stage.

7 Nov 2024

Researchers uncover immune mechanism behind myocarditis from cancer immunotherapy

Some patients being treated with immune checkpoint inhibitors, a type of cancer immunotherapy, develop a dangerous form of heart inflammation called myocarditis.

6 Nov 2024

New model sheds light on APOE4's role in Alzheimer's pathology

In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the presence of the APOE4 protein - the most important genetic risk factor for Alzheimer's disease - the same cells cause harmful inflammation and clumps of misfolded proteins, according to a new study by scientists at Gladstone Institutes.

4 Nov 2024

Scientists identify 16 types of nerve cells in human sense of touch

No less than 16 different types of nerve cells have been identified by scientists in a new study on the human sense of touch.

4 Nov 2024

New insights into early Huntington's disease mechanisms

Researchers uncover a link between impaired glutathione–ascorbate metabolism and early dopamine increases in Huntington's disease, suggesting GSTO2 as a potential therapeutic target to manage motor dysfunction.

4 Nov 2024

Exercise temporarily improves muscle insulin resistance linked to genetic risk for type 2 diabetes

The study uncovers how acute exercise alleviates insulin resistance in TBC1D4 variant carriers, underscoring the need for personalized diabetes interventions.

4 Nov 2024

Single-cell study identifies pro-metastatic cell subpopulations

Neuroblastoma (NB), the most prevalent extracranial solid tumor in children, poses a significant therapeutic challenge due to its metastasis and high heterogeneity. A recent study leveraging single-cell RNA sequencing (scRNA-seq) has uncovered vital molecular mechanisms underlying NB's progression and metastasis, shedding light on potential therapeutic targets.

3 Nov 2024