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Study investigates how breast cancer cells migrate to bone

Breast cancer cells frequently move from their primary site and invade bone, decreasing a patient's chance of survival. This process of metastasis is complex, and factors both within the breast cancer cells and within the new bone environment play a role. In next week's Journal of Biological Chemistry "Paper of the Week," Roger Gomis and colleagues at the Institute for Research in Biomedicine in Spain investigated how breast cancer cells migrate to bone.

14 Jun 2012

Azaya announces final results from ATI-1123 Phase I study on cancers

Azaya Therapeutics, Inc. announced final results from the Phase I study of its anti-cancer drug, ATI-1123 (liposomal docetaxel), today.

14 Jun 2012

Human-derived stem cells can spontaneously form optic cups and retina

Human-derived stem cells can spontaneously form the tissue that develops into the part of the eye that allows us to see, according to a study published by Cell Press in the 5th anniversary issue of the journal Cell Stem Cell.

14 Jun 2012

ChromaDex’s pTeroPure safe for human consumption

ChromaDex Corporation, an innovative natural products company that provides proprietary, science-based solutions and ingredients to the dietary supplement, food & beverage, animal health, cosmetic and pharmaceutical industries announced today its patented pTeroPure (pterostilbene) was shown to be safe for human consumption according to data from the first clinical trial of the substance.

13 Jun 2012

Fluidigm unveils details of new C1 Single-Cell AutoPrep System at ISSCR meeting

Fluidigm today unveiled the details of its new C1 Single-Cell AutoPrep System to attendees at the International Society for Stem Cell Research (ISSCR) meeting in Yokohama, Japan.

13 Jun 2012

New study on motor chunking

You pick up your cell phone and dial the new number of a friend. Ten numbers. One. Number. At. A. Time. Because you haven't actually typed the number before, your brain handles each button press separately, as a sequence of distinct movements.

13 Jun 2012

Scientists decipher and block a molecular message that prompts unbridled cellular growth

What's good news in one setting might spell disaster in another. In cancer for instance, when a certain cell is commanded to grow and divide without restraint, it's a welcome message for the cell itself but a tragedy for the person who harbors this cell in his or her body. Weizmann Institute scientists have managed to decipher and block one type of molecular message that prompts unbridled cellular growth.

13 Jun 2012

HLA B-27 protein appears to confer ability to suppress HIV viral replication

The rare ability of some individuals to control HIV infection with their immune system alone appears to depend - at least partially - on specific qualities of the immune system's killer T cells and not on how many of those cells are produced.

13 Jun 2012

Caspase-11 enzyme plays an important role in Legionella infection

New research shows that an enzyme that has long been considered relatively useless to the immune response instead has an important role in setting up immune cells to kill infection-causing bacteria.

13 Jun 2012

New tool should serve as cellular equivalent for children with CDG syndromes

Just as Gotham City uses the Bat Signal to call for Batman's aid, a new tool developed by scientists from the Sanford-Burnham Medical Research Institute in La Jolla, California, should serve as the cellular equivalent for children with glycosylation disorders, sometimes called "CDG syndromes."

13 Jun 2012

Acute and chronic elevation of EPO in the brain improve motivation for exercise

As science rushes to develop safe weight loss drugs, a new research report approaches this problem from an entirely new angle: What if there were a pill that would make you want to exercise harder? It may sound strange, but a new research report appearing online in The FASEB Journal suggests that it might be possible.

13 Jun 2012

Georgia Institute of Technology launches HomeLab

Baby boomers have witnessed many technological innovations, and they expect technology to provide them with solutions to help maintain their independence for as long as possible. They are outfitting their homes with products to help them live healthy lifestyles, manage chronic conditions, remember to take medications and remain connected with their caregivers.

13 Jun 2012

Genetic variability in the embryo may predispose to cancer in adult life

A study recently published in Nature Genetics provides new evidence that the genetic makeup of the embryo may cause the appearance of tumors in adult life. These results bear out the growing theory that some tumors may have an extremely early origin, tracing to the individual's embryonic development, while offering new clues to understand the genetic causes of certain kinds of cancer, and their prevention and treatment.

13 Jun 2012

Ischemic stroke on the rise among N.J. children

Stroke is one of the top 10 causes of death among children according to the National Stroke Association. A new study published today shows that in New Jersey, the diagnosis of ischemic stroke in children, resulting from a loss or obstruction of blood to the brain, is on the rise.

13 Jun 2012

Hepatocytes can create new liver system in mouse models

Researchers in Japan have found that hepatocytes, cells comprising the main tissue of the liver and involved in protein synthesis and storage, can assist in tissue engineering and create a "new liver system" in mouse models when donor mouse liver hepatocytes are isolated and propagated for transplantation.

12 Jun 2012

New approach can design antibiotics that kill even 'superbugs'

The world needs new antibiotics to overcome the ever increasing resistance of disease-causing bacteria - but it doesn't need the side effect that comes with some of the most powerful ones now available: hearing loss. Today, researchers report they have developed a new approach to designing antibiotics that kill even "superbugs" but spare the delicate sensory cells of the inner ear.

12 Jun 2012

Normal p53 gene makes breast cancer chemotherapy with doxorubicin less effective

Presence of normal p53, a tumor suppressor gene, instead of a mutated version, makes breast cancer chemotherapy with doxorubicin less effective. The preclinical study led by MD Anderson scientists was published today in the journal Cancer Cell.

12 Jun 2012

Researchers identify two proteins that are required to maintain kidney stem cells

Studying mice and humans, researchers at Washington University School of Medicine in St. Louis and their collaborators in Paris have identified two proteins that are required to maintain a supply of stem cells in the developing kidney.

12 Jun 2012

Researchers find pathway for origin and growth of the most common form of brain and spinal cord tumor – meningioma

Johns Hopkins researchers say they have discovered one of the most important cellular mechanisms driving the growth and progression of meningioma, the most common form of brain and spinal cord tumor.

12 Jun 2012

Promising preliminary data for axitinib in metastatic kidney cancer

Preliminary study data show that axitinib may be an effective first-line treatment for metastatic renal cell carcinoma, particularly in patients with high therapeutic drug exposure and a rise in blood pressure during the first 2 weeks of treatment, researchers report.

12 Jun 2012