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Researchers find that protein serves as on-off switch for "beigeing" of fat

Scientists this week reported that a molecular pathway called mTORC1 controls the conversion of unhealthy white fat into beige fat, an appealing target for increasing energy expenditure and reducing obesity.

6 Jun 2014

Lack of O2 in fat cells triggers inflammation and insulin resistance in obesity

Researchers at the University of California, San Diego School of Medicine have, for the first time, described the sequence of early cellular responses to a high-fat diet, one that can result in obesity-induced insulin resistance and diabetes.

6 Jun 2014

Chemist’s work could impact treatment of cancer and malaria

A University of Houston (UH) chemist hopes his work will one day impact the treatment of such diseases as cancer and malaria by better understanding how molecules react and how atoms come together to form bonds.

6 Jun 2014

Discovery may lead to relief for victims of range of neurological disorders

University of Toronto biologists leading an investigation into the cells that regulate proper brain function, have identified and located the key players whose actions contribute to afflictions such as epilepsy and schizophrenia.

6 Jun 2014

Device used in physics and chemistry reveals dynamics of pervasive pathogen

If you have it, you probably don't know it. Cytomegalovirus, or CMV, is perhaps one of the biggest pathogens you've never heard of-big, both proportionately and epidemiologically.

6 Jun 2014

Researchers take step toward restoring natural, high-fidelity vision to blind people

In laboratory tests, researchers have used electrical stimulation of retinal cells to produce the same patterns of activity that occur when the retina sees a moving object. Although more work remains, this is a step toward restoring natural, high-fidelity vision to blind people, the researchers say.

6 Jun 2014

Biomarkers help resolve differential diagnosis between MPM and non-cancerous pleural tissue

Scientists have identified four biomarkers that may help resolve the difficult differential diagnosis between malignant pleural mesothelioma (MPM) and non-cancerous pleural tissue with reactive mesothelial proliferations (RMPs).

6 Jun 2014

ImStem successfully treats animal model of multiple sclerosis using hESC

ImStem Biotechnology, Inc. (ImStem) announced today it has successfully treated an animal model of multiple sclerosis (MS) using human embryonic stem cells (hESC) derived mesenchymal stem cells (MSCs), called hES-MSCs.

6 Jun 2014

Ocugen's OCU100 gets FDA orphan drug designation for treatment of retinitis pigmentosa

Ocugen, Inc. and the University of Colorado today announced exclusive license agreements that allow for Ocugen to continue developing two drug candidates for the treatment for ophthalmology indications, and that one of the assets, OCU100, recombinant lens epithelium derived growth factor 1-326 (LEDGF1-326), received orphan-drug status from the U.S. Food and Drug Administration for treatment of retinitis pigmentosa (RP), a rare eye disease.

6 Jun 2014

Tolero Pharmaceuticals reports positive interim results from alvocidib Phase 2 trial for AML treatment

Tolero Pharmaceuticals, Inc., a late clinical-stage biopharmaceutical company developing treatments for oncology and blood disorders, reported positive interim results from an ongoing, randomized Phase 2 clinical trial of its lead drug candidate, alvocidib, in combination with cytarabine plus mitoxantrone for previously untreated acute myeloid leukemia (AML) patients.

6 Jun 2014

Immune Design begins treatment in LV305 Phase 1 clinical trial for cancer

Immune Design, a clinical-stage immunotherapy company focused on the development of novel immune-based therapies for cancer and other chronic conditions, today announced treatment of the first patient in a Phase 1 clinical trial of LV305, an immuno-oncology investigational agent from the company's DCVexTM lentiviral vector platform.

5 Jun 2014

INTEGRA's VIAFLO 96 handheld multichannel pipette improves efficiency of genetic screening

The Institute of Genetics and Development of Rennes, France reports on how, using a VIAFLO 96 handheld multichannel pipette from INTEGRA, they have been able to improve the efficiency and speed with which they replicate yeast strain collections and perform genetic screens in 96 well plates.

From INTEGRA Biosciences 5 Jun 2014

Biosafe launches SepaMax multiprocessing device for high throughput cell processing

In line with its mission of market innovator, Biosafe is proud to announce the launch of the SepaMax multiprocessing device, on the occasion of the International Cord Blood Symposium in San Francisco.

5 Jun 2014

RPB grants $500,000 to accelerate treatments for Retinitis Pigmentosa

Research to Prevent Blindness (RPB), the leading eye research foundation, is providing $500,000 to accelerate the development of treatments for Retinitis Pigmentosa (RP) -- a family of retinal diseases that progressively create extreme tunnel vision, loss of night vision and leave affected patients legally blind by the age of 40.

5 Jun 2014

Affymetrix, BioDiscovery launch new analysis software for cancer research

Affymetrix and BioDiscovery, Inc. today announced the launch of a new analysis software, Nexus Copy Number for Affymetrix, which is specifically for data generated by Affymetrix' genetic analysis platforms in cancer research, including CytoScan Cytogenetics Suite and OncoScan FFPE Assay Kit.

5 Jun 2014

Variety of lifestyle and health factors increase memory complaints among young adults

If you're depressed, don't get enough exercise or have high blood pressure, you may find yourself complaining more about memory problems, even if you're a young adult, according to a new UCLA study.

5 Jun 2014

Study reveals molecular mechanism of cell death

Researchers at VIB and Ghent University have unraveled the mechanism of necroptosis. This is a type of cell death that plays a crucial role in numerous diseases, from viral infections and loss of auditory nerve cells to multiple sclerosis, acute heart failure and organ transplantation.

5 Jun 2014

Geoff Keller Group of MHAUS hosts fundraising event to promote MH awareness

The Geoffrey Keller Memorial Open Water Swim held in honor of the late son of Curt and Kathy Keller to raise funds to research better ways of managing Malignant Hyperthermia during surgery, to improve methods of detecting MH, and for MH awareness.

5 Jun 2014

Thermo Fisher, Cellectis sign agreements on TALEN gene editing technology

Cellectis, a leader of engineered CART cell therapies, and Thermo Fisher Scientific announced today that they have entered into a series of agreements covering the uses of TAL nucleases under the brand name TALEN™.

5 Jun 2014

Scientists reproduce chromosomal modifications in human cells that cause certain cancer

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and the Centro Nacional de Investigaciones Oncol-gicas (CNIO) have succeeded in reproducing, in human cells, the chromosomal translocations that cause two types of cancer: acute myeloid leukemia and Ewing's sarcoma.

5 Jun 2014

Cell News and Research

Researchers find that protein serves as on-off switch for "beigeing" of fat

Lack of O2 in fat cells triggers inflammation and insulin resistance in obesity

Chemist’s work could impact treatment of cancer and malaria

Discovery may lead to relief for victims of range of neurological disorders

Device used in physics and chemistry reveals dynamics of pervasive pathogen

Researchers take step toward restoring natural, high-fidelity vision to blind people

Biomarkers help resolve differential diagnosis between MPM and non-cancerous pleural tissue

ImStem successfully treats animal model of multiple sclerosis using hESC

Ocugen's OCU100 gets FDA orphan drug designation for treatment of retinitis pigmentosa

Tolero Pharmaceuticals reports positive interim results from alvocidib Phase 2 trial for AML treatment

Immune Design begins treatment in LV305 Phase 1 clinical trial for cancer

INTEGRA's VIAFLO 96 handheld multichannel pipette improves efficiency of genetic screening

Biosafe launches SepaMax multiprocessing device for high throughput cell processing

RPB grants $500,000 to accelerate treatments for Retinitis Pigmentosa

Affymetrix, BioDiscovery launch new analysis software for cancer research

Variety of lifestyle and health factors increase memory complaints among young adults

Study reveals molecular mechanism of cell death

Geoff Keller Group of MHAUS hosts fundraising event to promote MH awareness

Thermo Fisher, Cellectis sign agreements on TALEN gene editing technology

Scientists reproduce chromosomal modifications in human cells that cause certain cancer

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