Heart Failure News and Research

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Heart failure (HF) is a condition in which a problem with the structure or function of the heart impairs its ability to supply sufficient blood flow to meet the body's needs. It should not be confused with cardiac arrest or myocardial infarction.

Researchers study safety of transendocardial stem cell injection in patients with ischemic cardiomyopathy

Alan W. Heldman, M.D., of the University of Miami Miller School of Medicine, and colleagues conducted a study to examine the safety of transendocardial stem cell injection with autologous mesenchymal stem cells and bone marrow mononuclear cells in patients with ischemic cardiomyopathy.

19 Nov 2013

Long-term use of PDE3 inhibitors can lead to increased risk for sudden cardiac death

Drugs known as PDE3 inhibitors save many lives by helping failing hearts do a better job of pumping blood. But those same medications come with a sometimes deadly cost when taken for long periods: an increased risk for sudden cardiac death.

19 Nov 2013

Researchers discover association between RDW levels and depression in heart disease patients

Researchers at the Intermountain Medical Center Heart Institute have discovered a link between elevated red cell distribution width levels and depression in patients being treated for heart disease.

19 Nov 2013

TOPCAT trial results of spironolactone presented at AHA Scientific Sessions

A late-breaking clinical trial, known as the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist trial, to be presented at the American Heart Association Scientific Sessions, November 18, 2013, demonstrates that spironolactone did not reduce the primary outcome of cardiovascular death, heart failure hospitalization, nor surviving a cardiac arrest in patients with heart failure and preserved ejection fraction (pump function). However, spironolactone did reduce the major burden faced by these patients-the risk of repeated hospitalizations for heart failure.

19 Nov 2013

Two drugs tested in larger trial fail to improve kidney function in patients with acute heart failure

Two drugs tested in a larger trial did not improve kidney function in acute heart failure patients, contrary to results of smaller studies. The results were presented today at the American Heart Association's Scientific Sessions 2013 in Dallas and simultaneously published in the Journal of the American Medical Association. Previous smaller studies showed that low-dose dopamine or low-dose nesiritide could improve kidney function and reduce fluid overload that is often present in hospitalized acute heart failure patients by increasing urine production.

19 Nov 2013

Paragonix files second 510(k) with FDA for Sherpa Pak Cardiac Transport System

Paragonix Technologies, Inc. today announced that it has successfully completed filing of a second Pre-Marketing Notification Application (510(k)) with the US Food and Drug Administration (FDA) for its Paragonix Sherpa Pak Cardiac Transport System(CTS).

18 Nov 2013

Experts develop new working formulation for reporting of cardiac antibody-mediated rejection

Antibody-mediated rejection of the transplanted heart is a recognized clinical complication and a major limitation to survival of patients who have undergone heart transplantation. Experts have now developed a new working formulation for the pathologic diagnosis, grading, and reporting of cardiac antibody-mediated rejection.

18 Nov 2013

Heart disease: The leading cause of deaths related to pregnancy in California

Heart disease is the leading cause of women's pregnancy-related deaths in California - but nearly one-third could be prevented, according to research presented at the American Heart Association's Scientific Sessions 2013.

18 Nov 2013

New procedure repairs the mitral valve in patients at high risk for open heart surgery

A minimally invasive procedure is the first effective treatment for patients who are high risk for standard open heart surgery for a leaking heart valve, a study led by a University of Virginia School of Medicine researcher has found.

14 Nov 2013

Mount Sinai researchers successfully test SUMO-1 gene therapy to reverse heart failure

Researchers at the Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai have successfully tested a powerful gene therapy, delivered directly into the heart, to reverse heart failure in large animal models.

14 Nov 2013

Neovasc's Tiara transcatheter mitral valve replacement technology gets US patent

Neovasc Inc. today announced that the first patent covering the company's innovative Tiara transcatheter mitral valve replacement technology has been issued by the US Patent and Trademark Office.

13 Nov 2013

Latest techniques for diagnosing, treating heart failure to be presented at EuroEcho-Imaging 2013

The latest science on the role of imaging in diagnosing and treating heart failure will be presented at EuroEcho-Imaging 2013, the official annual meeting of the European Association of Cardiovascular Imaging (EACVI), a registered branch of the European Society of Cardiology (ESC). It takes place during 11-14 December in Istanbul, Turkey, at the Istanbul Lutfi Kirdar Convention & Exhibition Centre (ICEC).

13 Nov 2013

Findings raise prospects for new therapies to protect heart from progressive disease

Some of the most commonly prescribed drugs for the treatment of heart failure are beta-blockers and nitrates, which help to relax blood vessels and decrease the heart's workload. The drugs were thought to produce those effects through distinct molecular pathways, but according to a new study led by scientists at Temple University School of Medicine, both types of drugs may help the failing heart by counteracting the effects of an enzyme known as GRK2.

8 Nov 2013

Landmark clinical trial of artificial aortic heart valve shows positive results

Loyola University Medical Center is the only Chicago hospital participating in a landmark clinical trial of an artificial aortic heart valve that does not require open heart surgery.

From Medtronic 8 Nov 2013

Oral allergy syndrome sufferers with hypertension may be at increased risk for severe reaction

Oral allergy syndrome sufferers that take high blood pressure medications may experience extreme facial swelling and difficulty breathing the next time they bite into a juicy apple.

8 Nov 2013

New coverage gaps, cost issues spur health law worries

News outlets look at the nuts and bolts of the health law's implementation, including a worry that coverage gaps will persist for some vulnerable people, as well as how the government pays for insurance subsidies and why some premium costs increase under the health law.

8 Nov 2013

Inhibition of heart protein reduces damage from heart attack, say researchers

The stop and start of blood flow to the heart during and after a heart attack causes severe damage to heart cells, reducing their capacity to function and potentially causing their death.

7 Nov 2013

Simple urine test can help identify disease risks in young type 1 diabetes patients

Using a simple urine test, researchers can now identify young people with type 1 diabetes at risk of heart and kidney disease. The new research, funded by JDRF, Diabetes UK, and the British Heart Foundation, was published today, 06 November, in the journal Diabetes Care.

7 Nov 2013

New study could help lead to prevention and treatment of heart failure in diabetics

Researchers from the University of Texas Medical Branch at Galveston have discovered one of the pathogenic components of diabetes in the heart, as published in the Journal of Biological Chemistry.

7 Nov 2013

SDSU receives $8.5M NIH grant to develop new heart treatments using stem cells

The National Institutes of Health has awarded a prestigious Program Project Grant totaling more than $8.5 million over five-years to San Diego State University to better understand how the heart heals and ways stem cells can help the heart repair itself.

6 Nov 2013

Heart Failure News and Research

Further Reading

Researchers study safety of transendocardial stem cell injection in patients with ischemic cardiomyopathy

Long-term use of PDE3 inhibitors can lead to increased risk for sudden cardiac death

Researchers discover association between RDW levels and depression in heart disease patients

TOPCAT trial results of spironolactone presented at AHA Scientific Sessions

Two drugs tested in larger trial fail to improve kidney function in patients with acute heart failure

Paragonix files second 510(k) with FDA for Sherpa Pak Cardiac Transport System

Experts develop new working formulation for reporting of cardiac antibody-mediated rejection

Heart disease: The leading cause of deaths related to pregnancy in California

New procedure repairs the mitral valve in patients at high risk for open heart surgery

Mount Sinai researchers successfully test SUMO-1 gene therapy to reverse heart failure

Neovasc's Tiara transcatheter mitral valve replacement technology gets US patent

Latest techniques for diagnosing, treating heart failure to be presented at EuroEcho-Imaging 2013

Findings raise prospects for new therapies to protect heart from progressive disease

Landmark clinical trial of artificial aortic heart valve shows positive results

Oral allergy syndrome sufferers with hypertension may be at increased risk for severe reaction

New coverage gaps, cost issues spur health law worries

Inhibition of heart protein reduces damage from heart attack, say researchers

Simple urine test can help identify disease risks in young type 1 diabetes patients

New study could help lead to prevention and treatment of heart failure in diabetics

SDSU receives $8.5M NIH grant to develop new heart treatments using stem cells

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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