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Scientists throw light on genetic mutation that causes particularly severe genetic disease ARVC5

The genetic disease ARVC leads to sudden cardiac death and is more common than it has been hitherto assumed. This is reported by an international team of researchers headed by Prof Dr Hendrik Milting from the Heart and Diabetes Center NRW in the "European Heart Journal".

7 Mar 2014

TAZ gene represents potential target for drug therapies to treat aggressive types of breast cancer

Significance: Understanding more about how the different types of cells in breast tissue develop improves our knowledge of breast cancer. TAZ represents a potential new target for drug therapies to treat aggressive types of breast cancer.

7 Mar 2014

Incyte Corporation publishes results of Phase III trial of ruxolitinib in patients with polycythemia vera

Incyte Corporation (Nasdaq: INCY) today announced that a pivotal Phase III trial of ruxolitinib compared to best available therapy in patients with polycythemia vera who are resistant to or intolerant of hydroxyurea has met its primary endpoint of achieving phlebotomy independence and reducing spleen size by 35 percent or more.

7 Mar 2014

Vitamin D boosts survival of breast cancer patients

Breast cancer patients with high levels of vitamin D in their blood are twice as likely to survive the disease as women with low levels of this nutrient, report University of California, San Diego School of Medicine researchers in the March issue of Anticancer Research.

7 Mar 2014

Researchers examine association between diabetes and obesity

It's by now well established that obesity is a major risk factor for diabetes. But what exactly is it about extra body fat that leads to insulin resistance and blood glucose elevation, the hallmarks of diabetes?

7 Mar 2014

Research reveals 2 key mechanisms of oxidative stress regulation

Regulation of oxidative stress is critical to cell survival. New preclinical research from Roswell Park Cancer Institute (RPCI) has revealed two key mechanisms by which oxidative stress is regulated in normal and cancerous cells.

7 Mar 2014

Ludwig, Agenus to advance three monoclonal antibody checkpoint modulators into preclinical development

Ludwig Cancer Research and Agenus Inc. today announced the selection of three monoclonal antibody checkpoint modulators (CPMs) that Agenus is advancing into preclinical development.

7 Mar 2014

UH physicist to develop new therapies targeting cancer and Alzheimer's

Working toward new therapies to target cancer and Alzheimer's, University of Houston (UH) physicist Margaret Cheung strives to understand the physics that govern how ordinary matter becomes life-like.

7 Mar 2014

Study to understand how bisphenol-A may promote breast cancer growth

UT Arlington biochemists say their newly published study brings researchers a step closer to understanding how the commonly used synthetic compound bisphenol-A, or BPA, may promote breast cancer growth.

6 Mar 2014

New findings shed light on how gene mutation causes motor neurone disease

Researchers have discovered a mechanism that may explain how a recently discovered mutation causes two devastating neurological diseases.

6 Mar 2014

Inflammation and stress combine in bipolar and schizophrenia subtypes

Researchers have found that some individuals with bipolar disorder or schizophrenia have combined stress response and immune dysfunctions.

6 Mar 2014

Study links association between eating red, processed meat and risk of developing cancer in gut

Recent reports warn about a link between eating red and processed meat and the risk of developing cancer in the gut. These reports have resulted in new nutritional recommendations that advise people to limit their intake of red and processed meats.

6 Mar 2014

Study shows how changes in organized cell membrane network of heart muscle leads to heart failure

Colchicine, a drug that's used to treat gout, has the beneficial side effect of lowering the risk of heart attack in patients taking it. Conversely, taxol, a drug for treating cancer, has the opposite effect; raising the risk of heart failure.

6 Mar 2014

Elsevier launches medical reference and learning platforms for clinicians, students

Elsevier, a world-leading provider of scientific, technical and medical information products and services, today announced the launch of the fully redesigned Expert Consult and Student Consult, its two medical reference and learning platforms, now powered by Inkling, the creator of engaging, intuitive digital books for some of the world's most respected publishers.

6 Mar 2014

Researchers identify high-speed cellular transport mechanism

Our DNA and its architecture are duplicated every time our cells divide. Histone proteins are key building blocks of this architecture and contain crucial information that regulates our genes. Danish researchers show how an enzyme controls reliable and high-speed delivery of histones to DNA copying hubs in our cells. This shuttling mechanism is crucial to maintain normal function of our genes and prevent disease. The results are published in the journal Nature Communications.

6 Mar 2014

Scientists describes new advantageous way to detect different immune cells in the blood

When a person becomes sick or is exposed to an unwelcome substance, the body mobilizes specific proportions of different immune cells in the blood. Methods of discovering and detecting those profiles are therefore useful both clinically and in research. In a new paper in the journal Genome Biology, a team of scientists describes a new and uniquely advantageous way to detect them.

6 Mar 2014

New drug is effective against superbug MRSA

"I routinely call hospitals and request their yearly antibiotic susceptibility testing data," said Washington University in St. Louis' Timothy Wencewicz. "The log might say, for example, that they've treated hundreds of patients for Acinetobacter baumanni, a bacterium brought into U.S. hospitals by soldiers wounded in the Iraq war, with 30 different antibiotics.

6 Mar 2014

Cell News and Research

Scientists throw light on genetic mutation that causes particularly severe genetic disease ARVC5

TAZ gene represents potential target for drug therapies to treat aggressive types of breast cancer

Incyte Corporation publishes results of Phase III trial of ruxolitinib in patients with polycythemia vera

Vitamin D boosts survival of breast cancer patients

Researchers examine association between diabetes and obesity

Research reveals 2 key mechanisms of oxidative stress regulation

Ludwig, Agenus to advance three monoclonal antibody checkpoint modulators into preclinical development

UH physicist to develop new therapies targeting cancer and Alzheimer's

Study to understand how bisphenol-A may promote breast cancer growth

New findings shed light on how gene mutation causes motor neurone disease

Inflammation and stress combine in bipolar and schizophrenia subtypes

Study links association between eating red, processed meat and risk of developing cancer in gut

Study shows how changes in organized cell membrane network of heart muscle leads to heart failure

Elsevier launches medical reference and learning platforms for clinicians, students

Researchers identify high-speed cellular transport mechanism

Scientists describes new advantageous way to detect different immune cells in the blood

New drug is effective against superbug MRSA

Scientists reveal how a genetic code variation results in devastating brain diseases

New bioinspired gel material could help repair damaged teeth and bone

Novel cancer immunotherapy approach may provide new weapon against most deadly tumors

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