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UH scientists working to develop next generation of prostate cancer therapies

A University of Houston scientist and his team are working to develop the next generation of prostate cancer therapies, which are targeted at metabolism.

27 Feb 2014

H4 receptor activation plays part in NSCLC progression

Histamine H4 receptor activation decreases epithelial-to-mesenchymal transmission in non-small-cell lung cancer, Chinese research shows.

27 Feb 2014

Motesanib boosts carboplatin/paclitaxel efficacy in NSCLC

Adding motesanib to carboplatin/paclitaxel significantly improves overall survival in Asian patients with nonsquamous non-small-cell lung cancer compared with carboplatin/paclitaxel alone, researchers report.

27 Feb 2014

Scientists reveal two regulatory mechanisms that keep the body's immune response in check

A Keck Medicine of USC-led team of microbiologists has identified previously unknown interactions between critical proteins in the human immune response system, uncovering two independent regulatory mechanisms that keep the body's immune response in check. Their findings appear in the February 2014 edition of Cell Host & Microbe, the top peer-reviewed scientific journal that focuses on the study of cell-pathogen interaction.

27 Feb 2014

Researchers create new nerve cells in brains and spinal cords of living mammals

UT Southwestern Medical Center researchers created new nerve cells in the brains and spinal cords of living mammals without the need for stem cell transplants to replenish lost cells.

27 Feb 2014

Vitamin A may play key role in combating TB, says study

Tuberculosis is a major global problem, affecting 2 billion people worldwide and causing an estimated 2 million deaths annually. Western countries are once again tackling the disease, with recent outbreaks in Los Angeles and London.

27 Feb 2014

Researchers discover new target for human antibodies that holds key to vaccine for dengue

Creating a vaccine that protects people from all four types of dengue virus has frustrated scientists for decades. But researchers at the University of North Carolina have discovered a new target for human antibodies that could hold the key to a vaccine for the world's most widespread mosquito-borne disease.

27 Feb 2014

cfDNA testing lowers false positive rates and higher predictive values in general obstetric population

A study in this week's New England Journal of Medicine potentially has significant implications for prenatal testing for major fetal chromosome abnormalities. The study found that in a head-to-head comparison of noninvasive prenatal testing using cell free DNA (cfDNA) to standard screening methods, cfDNA testing (verifi- prenatal test, Illumina, Inc.) significantly reduced the rate of false positive results and had significantly higher positive predictive values for the detection of fetal trisomies 21 and 18.

From Illumina, Inc. 27 Feb 2014

Depression and self-awareness affect subjective reports of memory and satisfaction with life

Kessler Foundation researchers have found that among individuals with TBI, depression and self-awareness affect subjective reports of memory, quality of life (QOL), and satisfaction with life.

26 Feb 2014

Researchers create new probe that freezes cells to "see" at greater detail without damaging

It's an odd twist. For scientists to determine if a cell is functioning properly, they must destroy it. This is what happens in X-ray fluorescence microscopy when biological specimens are exposed to ionizing radiation, which provides images with a level of detail that conventional microscopes just can't match.

26 Feb 2014

Elsevier titles recognized in AJN Book of the Year Awards

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26 Feb 2014

Therapeutic hypothermia may not be effective in all patients who suffered heart attack, says study

Whole body cooling in comatose patients who have suffered a heart attack can limit the damage to brain tissue caused by the restoration of blood flow and oxygen.

26 Feb 2014

Study explores influence of reproductive, hormonal factors on overall survival of women with NSCLC

Survival among people with lung cancer has been better for women than men, and the findings of a recent study indicate that female hormones may be a factor in this difference.

26 Feb 2014

Cognitive decline in obese diabetic mice can be reversed with regular exercise, surgical removal of belly fat

Cognitive decline that often accompanies obesity and diabetes can be reversed with regular exercise or surgical removal of belly fat, scientists report.

26 Feb 2014

Novel SCLC tumour suppressor gene discovered

Inactivation of the MYC-associated factor X gene, MAX, may play a significant role in the development of small-cell lung cancer, scientists believe.

26 Feb 2014

Viewpoints: Finding a plan for 'tinkering with DNA'; fact-checking claims of ACA losses; pediatricians' fears of retail clinics

The manipulation of human genes could lead to profound advances in our ability to cure or prevent terrible diseases. But in some cases, it might also mean introducing genetic material that could be passed from one generation to the next, changing the human gene pool in a manner that could inadvertently harm peoples' health.

26 Feb 2014

Prothelia and University of Nevada, Reno enter into agreements with Alexion for development of Laminin-111

Prothelia Incorporated (Prothelia) and University of Nevada, Reno announce that they have entered into strategic agreements with Alexion for the development of Laminin-111, a patented experimental protein replacement therapy for merosin-deficient congenital muscular dystrophy (MDC1A), a life-threatening, ultra-rare disease caused by a genetic deficiency of the Laminin-211 protein.

26 Feb 2014

Study highlights the importance of personalized medicine for treating cancer

If a driver is traveling to New York City, I-95 might be their route of choice. But they could also take I-78, I-87 or any number of alternate routes. Most cancers begin similarly, with many possible routes to the same disease. A new study found evidence that assessing the route to cancer on a case-by-case basis might make more sense than basing a patient's cancer treatment on commonly disrupted genes and pathways.

26 Feb 2014

Protein M: an interview with Rajesh Grover, PhD, senior staff scientist, Lerner laboratory, TSRI

Protein M is a cell surface protein from Mycoplasma Genitalium that binds to all human antibodies.

26 Feb 2014

FDA approves KALYDECO for people with cystic fibrosis

Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced the U.S. Food and Drug Administration (FDA) approved a supplemental New Drug Application (sNDA) for KALYDECOTM (ivacaftor) for people with cystic fibrosis (CF) ages 6 and older who have one of eight additional mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. KALYDECO was first approved in January 2012 for people with CF ages 6 and older who have at least one copy of the G551D mutation.

26 Feb 2014

Cell News and Research

UH scientists working to develop next generation of prostate cancer therapies

H4 receptor activation plays part in NSCLC progression

Motesanib boosts carboplatin/paclitaxel efficacy in NSCLC

Scientists reveal two regulatory mechanisms that keep the body's immune response in check

Researchers create new nerve cells in brains and spinal cords of living mammals

Vitamin A may play key role in combating TB, says study

Researchers discover new target for human antibodies that holds key to vaccine for dengue

cfDNA testing lowers false positive rates and higher predictive values in general obstetric population

Depression and self-awareness affect subjective reports of memory and satisfaction with life

Researchers create new probe that freezes cells to "see" at greater detail without damaging

Elsevier titles recognized in AJN Book of the Year Awards

Therapeutic hypothermia may not be effective in all patients who suffered heart attack, says study

Study explores influence of reproductive, hormonal factors on overall survival of women with NSCLC

Cognitive decline in obese diabetic mice can be reversed with regular exercise, surgical removal of belly fat

Novel SCLC tumour suppressor gene discovered

Viewpoints: Finding a plan for 'tinkering with DNA'; fact-checking claims of ACA losses; pediatricians' fears of retail clinics

Prothelia and University of Nevada, Reno enter into agreements with Alexion for development of Laminin-111

Study highlights the importance of personalized medicine for treating cancer

Protein M: an interview with Rajesh Grover, PhD, senior staff scientist, Lerner laboratory, TSRI

FDA approves KALYDECO for people with cystic fibrosis

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