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Advanced age should not preclude sunitinib use for mRCC

Elderly kidney cancer patients benefit from sunitinib therapy just as much as their younger counterparts, a retrospective analysis of six clinical trials shows.

21 Feb 2014

Researchers develop new method to obtain three chemically different patches on same microparticle

Micromachines, nanorobots, multifunctional drug transporters, and matrices for tissue growth – these and many other applications would benefit from three-dimensional microstructures that present different (bio)chemical ligands that offer control over directionality. In the journal Angewandte Chemie, a team of German and American researchers has now reported the production of microparticles whose surface consists of three separate areas (“patches”) that can be decorated with three different (bio)molecules.

21 Feb 2014

Chewable drug candidate BTI320 can potentially prevent added sugar intake

It's official: sugar is not so sweet—for our health, that is. The new study "Added Sugar Intake and Cardiovascular Diseases Mortality Among US Adults," published in JAMA Internal Medicine, examines the intake of "added sugars," and the results suggest that sugar is now an independent risk factor for heart disease and other chronic diseases.

21 Feb 2014

Study: Recurrence of SCCOP may differ in HPV-positive and HPV-negative patients

Patients with HPV-positive squamous cell carcinoma of the oropharynx (SCCOP) had a longer time to development of distant metastasis (DM) after initial treatment, and had more metastatic sites in more atypical locations compared to HPV-negative patients, according to research presented today at the 2014 Multidisciplinary Head and Neck Cancer Symposium.

21 Feb 2014

MATH biomarker with HPV status may provide improved outcomes in HNSCC patients

Evaluating next-generation sequencing (NGS) data and associated clinical records of head and neck squamous cell carcinoma (HNSCC) patients from several institutions, made available through The Cancer Genome Atlas (TCGA), showed that combining Mutant-Allele Tumor Heterogeneity (MATH) as a biomarker with the patient's HPV status provides an effective indicator of improved patient outcome, according to research presented today at the 2014 Multidisciplinary Head and Neck Cancer Symposium.

21 Feb 2014

Lone star tick bites are likely the cause of severe red meat allergies

Lone star tick bites are likely the cause of thousands of cases of severe red meat allergies that are plaguing patients in Southeastern states including Tennessee, North Carolina and Virginia and spreading up the Eastern Seaboard along with the deer population.

21 Feb 2014

Study determines effectiveness of gabapentin for treatment of vulvodynia in women

A chronic syndrome called vulvodynia that affects from four to seven percent of women is being studied by physicians at The Women's Health Institute at Robert Wood Johnson Medical School, part of Rutgers, The State University of New Jersey, in hopes of alleviating sometimes excruciating pain.

21 Feb 2014

Epidemiological studies demonstrate that diseases of central nervous system protect against cancer

Epidemiological studies demonstrate that diseases of the central nervous system such as Alzheimer, Parkinson and schizophrenia protect against cancer. The most remarkable example is Alzheimer's disease, which can reduce the risk of suffering from cancer by up to 50%.

21 Feb 2014

HPV-positive patients with OPSCC show higher overall survival rate than HPV-negative patients

A retrospective analysis of oropharyngeal patients with recurrence of disease after primary therapy in the Radiation Therapy Oncology Group (RTOG) studies 0129 or 0522 found that HPV-positive patients had a higher overall survival (OS) rate than HPV-negative patients (at two years post-treatment, 54.6 percent vs. 27.6 percent, respectively), according to research presented today at the 2014 Multidisciplinary Head and Neck Cancer Symposium.

20 Feb 2014

Pharmacyclics total revenue for fourth quarter 2013 increases 113% to $123.6 million

Pharmacyclics, Inc. today reported financial results and recent developments for the quarter and year ended December 31, 2013.

20 Feb 2014

Predictors of bone metastasis, skeletal events in lung cancer identified

Researchers have identified a range of factors that are associated with the likelihood that a patient with advanced lung cancer will develop bone metastases or skeletal-related events.

20 Feb 2014

Lung cancer patients with Del19 mutation benefit most from afatinib

Afatinib has been approved in Germany since September 2013 for the treatment of adult patients with locally advanced or metastatic non-small cell lung cancer with activating EGF receptor mutations who have not been treated with an EGF receptor tyrosine-kinase inhibitor (EGFR TKI).

20 Feb 2014

Newly developed compound may allow blind see light

Progressive degeneration of photoreceptors-the rods and cones of the eyes-causes blinding diseases such as retinitis pigmentosa and age-related macular degeneration. While there are currently no available treatments to reverse this degeneration, a newly developed compound allows other cells in the eye to act like photoreceptors. As described in a study appearing in the February 19 issue of the Cell Press journal Neuron, the compound may be a potential drug candidate for treating patients suffering from degenerative retinal disorders.

20 Feb 2014

Pediatric Cancer Genome Project identifies genetic alteration in brain tumor ependymoma

The St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project has identified the most common genetic alteration ever reported in the brain tumor ependymoma and evidence that the alteration drives tumor development. The research appears February 19 as an advanced online publication in the scientific journal Nature.

20 Feb 2014

Certain fragments of DNA shed by tumors can be used to non-invasively screen for early-stage cancers

Certain fragments of DNA shed by tumors into the bloodstream can potentially be used to non-invasively screen for early-stage cancers, monitor responses to treatment and help explain why some cancers are resistant to therapies, according to results of an international study led by Johns Hopkins Kimmel Cancer Center investigators.

20 Feb 2014

UPV/EHU researchers develop method for diagnosis, prognosis of cutaneous melanoma

UPV/EHU researchers have developed a method for the diagnosis and prognosis of cutaneous melanoma, the type of skin cancer with the highest mortality rate.This method will help not only in the more effective early detection of this cancer, but also in the development of more personalised treatments.

20 Feb 2014

Mauna Kea installs flagship Cellvizio system at Apollo Gleneagles Hospital in Kolkata

Mauna Kea Technologies (Paris:MKEA) (Euronext: MKEA, FR0010609263), leader in the optical biopsy market, announced today it has installed its flagship Cellvizio system at the Apollo Gleneagles Hospital in Kolkata, a leading center of excellence in Gastroenterology in India, part of the Apollo Hospitals Group.

20 Feb 2014

Cell News and Research

Advanced age should not preclude sunitinib use for mRCC

Researchers develop new method to obtain three chemically different patches on same microparticle

Chewable drug candidate BTI320 can potentially prevent added sugar intake

Study: Recurrence of SCCOP may differ in HPV-positive and HPV-negative patients

MATH biomarker with HPV status may provide improved outcomes in HNSCC patients

Lone star tick bites are likely the cause of severe red meat allergies

Study determines effectiveness of gabapentin for treatment of vulvodynia in women

Epidemiological studies demonstrate that diseases of central nervous system protect against cancer

HPV-positive patients with OPSCC show higher overall survival rate than HPV-negative patients

Pharmacyclics total revenue for fourth quarter 2013 increases 113% to $123.6 million

Predictors of bone metastasis, skeletal events in lung cancer identified

Lung cancer patients with Del19 mutation benefit most from afatinib

Newly developed compound may allow blind see light

Pediatric Cancer Genome Project identifies genetic alteration in brain tumor ependymoma

Certain fragments of DNA shed by tumors can be used to non-invasively screen for early-stage cancers

UPV/EHU researchers develop method for diagnosis, prognosis of cutaneous melanoma

Mauna Kea installs flagship Cellvizio system at Apollo Gleneagles Hospital in Kolkata

Purdue’s new innovation improves drug therapies by making real-time decisions about treatment options

Vaccine-based clinical trial to improve survival outcomes of kidney cancer patients

NIH-funded session in Bethesda to heighten awareness of underactive bladder

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