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Extracts from birch tree helps damaged skin around wounds to regenerate more quickly

Extracts from the birch tree have served for centuries as a traditional means of helping the damaged skin around wounds to regenerate more quickly. Prof. Dr. Irmgard Merfort from the Institute of Pharmaceutical Sciences of the University of Freiburg and her team have now explained the molecular mechanism behind the wound-healing effect of an extract from the outer white layer of the tree's bark.

24 Jan 2014

Salmonella infections can reduce incidence of asthma, say researchers

Researchers from Germany have identified the mechanism by which Salmonella infections can reduce the incidence of asthma in mice. The research, which appears ahead of print in the journal Infection and Immunity, opens up new avenues of research that could lead to treatments.

24 Jan 2014

Rival proteins’ relative expression levels in cancer cells could be biomarkers for prognosis, treatment

Consider two drivers, each with a key that fits the same car. Driver 1 wants simply to turn on the ignition and leave the vehicle idling, ready and waiting to roll. Driver 2 wants to take it on a destructive joy ride.

24 Jan 2014

Statistical methods improve biological single-cell analyses

Each cell in our body is unique. Even cells of the same tissue type that look identical under the microscope differ slightly from each other.

24 Jan 2014

Use of twice-daily pill could turn deadly blood cancer into highly treatable disease

Use of a twice-daily pill could turn a deadly blood cancer into a highly treatable disease, according to scientists at Weill Cornell Medical College who led a multinational research team.

24 Jan 2014

Investigators develop human iPSCs capable of repairing damaged retinal vascular tissue in mice

Investigators at Johns Hopkins report they have developed human induced-pluripotent stem cells (iPSCs) capable of repairing damaged retinal vascular tissue in mice. The stem cells, derived from human umbilical cord-blood and coaxed into an embryonic-like state, were grown without the conventional use of viruses, which can mutate genes and initiate cancers, according to the scientists.

24 Jan 2014

Scientists develop mathematical model to predict tumor behavior and personalized therapies

Dana-Farber Cancer Institute scientists have developed a mathematical model to predict how a patient's tumor is likely to behave and which of several possible treatments is most likely to be effective.

24 Jan 2014

Johns Hopkins researchers reveal how calcium is controlled in the body

Scientists at Johns Hopkins report they have figured out a key step in how “free” calcium — the kind not contained in bones — is managed in the body, a finding that could aid in the development of new treatments for a variety of neurological disorders that include Parkinson’s disease.

24 Jan 2014

New technique detects bacterium that causes Legionnaires’ disease

The bacterium that causes Legionnaires’ disease remains difficult to track. French researchers have now developed a new technique that should allow living representatives of this dangerous pathogen to be detected much more quickly than with conventional methods. As they report in the journal Angewandte Chemie, samples are exposed to an azide-modified compound that the pathogen specifically incorporates into its shell, which is made of saccharide units. A fluorescent marker attached to the azide groups is used to identify the pathogen.

24 Jan 2014

Scientists map genetic changes that drive tumors pediatric soft-tissue cancer

Scientists have mapped the genetic changes that drive tumors in rhabdomyosarcoma, a pediatric soft-tissue cancer, and found that the disease is characterized by two distinct genotypes.

24 Jan 2014

USF Health receives $2.1M grant to study on new factors required for growth of malaria-related parasites

Animal cells similar to those of humans contain a "control room," called the centrosome, which regulates cell replication. Disrupt this core hub and you kill cell division.

24 Jan 2014

Etoposide plus cisplatin remains best for limited-stage SCLC

Etoposide plus cisplatin, given alongside accelerated hyperfractionated thoracic radiotherapy, remains the gold standard regimen for patients with limited-stage small-cell lung cancer, Japanese researchers say.

23 Jan 2014

CUMC researchers identify gene that appears to play major role in motor neuron degeneration in ALS

Columbia University Medical Center researchers have identified a gene, called matrix metalloproteinase-9 (MMP-9), that appears to play a major role in motor neuron degeneration in amyotrophic lateral sclerosis, also known as Lou Gehrig's disease. The findings, made in mice, explain why most but not all motor neurons are affected by the disease and identify a potential therapeutic target for this still-incurable neurodegenerative disease. The study was published today in the online edition of the journal Neuron.

23 Jan 2014

CytRx initiates aldoxorubicin Phase 2 trial in HIV-infected patients with Kaposi's sarcoma

CytRx Corporation, a biopharmaceutical research and development company specializing in oncology, today announced it has initiated a Phase 2 clinical trial to determine preliminary efficacy and safety of aldoxorubicin for HIV-infected patients with Kaposi's sarcoma.

23 Jan 2014

BioLineRx's BL-8040 gets FDA Orphan Drug Designation for stem cell mobilization treatment

BioLineRx, a clinical-stage biopharmaceutical company dedicated to identifying, in-licensing and developing promising therapeutic candidates, announced today that it has received notice from the U.S. Food & Drug Administration confirming an Orphan Drug Designation of BL-8040 as a treatment for stem cell mobilization, in addition to the Orphan Drug Designation previously granted to BL-8040 as a treatment for Acute Myeloid Leukemia.

23 Jan 2014

Next-generation high content screening system launched by PerkinElmer

PerkinElmer Inc., a global leader focused on the health and safety of people and the environment, has announced the launch of the Opera Phenix™, a next-generation, confocal, high-content screening system that will enable scientists to perform the most challenging applications with greater speed and sensitivity, accelerating the understanding of disease and discovery of new and more effective treatments.

23 Jan 2014

Inovio Pharmaceuticals unveils new DNA-based cytokine immune activator

Inovio Pharmaceuticals, Inc. today unveiled that the company has developed a new DNA-based cytokine immune activator, interleukin -33 (IL-33), that in combination with optimized DNA vaccines delivered by electroporation increased the potency and efficacy of the therapeutic response to the DNA vaccines in a preclinical study.

23 Jan 2014

CWRU researchers receive NIAID grant to conduct HIV research and clinical trials

AIDS researchers from Case Western Reserve University and University Hospitals Case Medical Center have received a seven-year funding award from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

23 Jan 2014

Rice University-based research develops fast biosensor for pathogens in food

An array of tiny diving boards can perform the Olympian feat of identifying many strains of salmonella at once.

23 Jan 2014

Latinos see diabetes as the biggest health problem for their families, new poll finds

A new NPR/Robert Wood Johnson Foundation/Harvard School of Public Health poll was released today on the views of Latinos in America about their health and health care, communities, financial situation, and discrimination in their lives. The poll found that Latinos see diabetes as the biggest health problem for their own families.

23 Jan 2014

Cell News and Research

Extracts from birch tree helps damaged skin around wounds to regenerate more quickly

Salmonella infections can reduce incidence of asthma, say researchers

Rival proteins’ relative expression levels in cancer cells could be biomarkers for prognosis, treatment

Statistical methods improve biological single-cell analyses

Use of twice-daily pill could turn deadly blood cancer into highly treatable disease

Investigators develop human iPSCs capable of repairing damaged retinal vascular tissue in mice

Scientists develop mathematical model to predict tumor behavior and personalized therapies

Johns Hopkins researchers reveal how calcium is controlled in the body

New technique detects bacterium that causes Legionnaires’ disease

Scientists map genetic changes that drive tumors pediatric soft-tissue cancer

USF Health receives $2.1M grant to study on new factors required for growth of malaria-related parasites

Etoposide plus cisplatin remains best for limited-stage SCLC

CUMC researchers identify gene that appears to play major role in motor neuron degeneration in ALS

CytRx initiates aldoxorubicin Phase 2 trial in HIV-infected patients with Kaposi's sarcoma

BioLineRx's BL-8040 gets FDA Orphan Drug Designation for stem cell mobilization treatment

Next-generation high content screening system launched by PerkinElmer

Inovio Pharmaceuticals unveils new DNA-based cytokine immune activator

CWRU researchers receive NIAID grant to conduct HIV research and clinical trials

Rice University-based research develops fast biosensor for pathogens in food

Latinos see diabetes as the biggest health problem for their families, new poll finds

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