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Advanced melanoma treatments: an interview with Dr. James Larkin, Consultant Medical Oncologist, The Royal Marsden

Advanced melanoma affects around 2,000 people per year in the UK. Advanced melanoma describes a melanoma that has spread from its site of origin to other areas of the body.

22 Jan 2014

Scientists identify specific enzyme essential for brain development

Scientists from the Max F. Perutz Laboratories (MFPL) of the University of Vienna and the Medical University of Vienna have identified a specific enzyme, histone deacetylase 2 (HDAC2), as essential for brain development. The findings published in Development are important to advance the development of new drugs to treat neurological diseases.

22 Jan 2014

CytRx receives FDA approval to continue dosing aldoxorubicin for patients with soft tissue sarcomas

CytRx Corporation (NASDAQ:CYTR), a biopharmaceutical research and development company specializing in oncology, today announced it has received approval from the U.S. Food and Drug Administration (FDA) to continue dosing patients with aldoxorubicin until disease progression in a planned pivotal, global Phase 3 clinical trial with aldoxorubicin as a second-line treatment for soft tissue sarcomas.

22 Jan 2014

UT Southwestern' faculty receives Stanley J. Korsmeyer Award for contributions to understanding of autophagy

Dr. Beth Levine, a Howard Hughes Medical Institute Investigator and Director of the Center for Autophagy Research at UT Southwestern Medical Center, has received the 2014 Stanley J. Korsmeyer Award from the American Society for Clinical Investigation.

22 Jan 2014

Italian biochemist receives Louis-Jeantet Prize for Medicine for the year 2014

The 2014 LOUIS-JEANTET PRIZE FOR MEDICINE is awarded to the Italian biochemist Elena Conti, Director of the Department of Structural Cell Biology at the Max-Planck Institute of Biochemistry in Munich (Germany) and to Denis Le Bihan, the French medical doctor, physicist and Director of NeuroSpin, an institute at the French Nuclear and Renewable Energy Commission (CEA) at Saclay near Paris.

22 Jan 2014

Parkin and PINK1 function in vesicular trafficking pathway regulates mitochon-drial quality control

Scientists from the Montreal Neurological Institute and Hospital in Canada have discovered that two genes linked to hereditary Parkinson's disease are involved in the early-stage quality control of mitochondria.

22 Jan 2014

Researchers suggest new targets may provide druggable alternatives to Ewing's Sarcoma

Ewing's Sarcoma is an aggressive pediatric cancer, most commonly caused by the improper fusion of the gene EWS with the gene FLI1. Though the cause has long been known, therapeutic targeting of this fusion has to date proven very difficult.

22 Jan 2014

Scientists showcase HDL nanotherapy that may provide solution to repeat heart attacks

Up to 30 percent of heart attack patients suffer a new heart attack because cardiologists are unable to control inflammation inside heart arteries - the process that leads to clots rupturing and causing myocardial infarction or stroke.

22 Jan 2014

Scientists identify channel that acts as 'brake', limiting spontaneous pain

Scientists have identified a channel present in many pain detecting sensory neurons that acts as a 'brake', limiting spontaneous pain. It is hoped that the new research, published today [22 January] in the Journal of Neuroscience, will ultimately contribute to new pain relief treatments.

22 Jan 2014

Magnetoencephalography can be used to control and train specific targeted brain regions

A new brain-imaging technique enables people to 'watch' their own brain activity in real time and to control or adjust function in pre-determined brain regions. The study from the Montreal Neurological Institute and Hospital - The Neuro, McGill University and the McGill University Health Centre, published in NeuroImage, is the first to demonstrate that magnetoencephalography can be used as a potential therapeutic tool to control and train specific targeted brain regions.

21 Jan 2014

New guidance recommends prevention of healthcare-associated infections transmitted through HCP attire

New guidance from the Society for Healthcare Epidemiology of America provides recommendations to prevent transmission of healthcare-associated infections through healthcare personnel attire in non-operating room settings.

21 Jan 2014

Mutation in bone cells may cause acute myeloid leukemia: Study

Acute myeloid leukemia is a blood cancer, but for many patients the cancer may originate from an unusual source: a mutation in their bone cells.

21 Jan 2014

Damon Runyon Cancer Research Foundation awards $2.25M to six innovative young scientists

The Damon Runyon Cancer Research Foundation announced that six scientists with novel approaches to fighting cancer have been named 2014 recipients of the Damon Runyon-Rachleff Innovation Award. The grant of $450,000 over three years is awarded each year to early career scientists whose projects have the potential to significantly impact the prevention, diagnosis and treatment of cancer.

21 Jan 2014

Fluxion Biosciences announces release of IsoFlux Rare Cell Enrichment Kit

Fluxion Biosciences, Inc. announced the release of a new reagent kit for the IsoFlux System designed to provide more options for circulating tumor cell and other rare cell capture from biological samples. The IsoFlux Rare Cell Enrichment (Streptavidin) Kit incorporates streptavidin-coated magnetic beads that can bind with one or more biotinylated antibodies targeted towards cell-surface markers on the cells of interest.

From Fluxion Biosciences 21 Jan 2014

HUB Foundation for Organoid Technology signs licensing agreement with STEMCELL Technologies

The HUB Foundation for Organoid Technology announced today that it has signed a licensing agreement with STEMCELL Technologies Inc. for the manufacturing and worldwide distribution of cell culture media for growing Organoids. Organoids are mini-organs grown in tissue culture from small pieces of tissue derived from patients with cancer and other diseases, and represent an exciting new tool for scientific research and drug discovery and validation.

21 Jan 2014

First patient dosed in ADXS-HPV Phase 1/2 study for HPV-associated head and neck cancer

Advaxis, Inc., a leader in developing the next generation of cancer immunotherapies, announced that the first patient has been dosed in a Phase 1/2 "window of opportunity" study being conducted by the Icahn School of Medicine at Mount Sinai. Patients diagnosed with HPV-associated head and neck cancer will receive ADXS-HPV immunotherapy during the "window" of time between initial diagnosis and minimally invasive transoral robotic surgery to remove their tumors.

21 Jan 2014

Affymetrix gets FDA clearance to market CytoScan Dx Assay

Affymetrix, Inc. today announced that it has received 510(k) clearance from the U.S. Food and Drug Administration to market its CytoScan Dx Assay. This assay is intended for the postnatal detection of DNA copy number variants in patients referred for chromosomal testing. CytoScan Dx Assay is designed to help physicians diagnose children's developmental and intellectual disabilities more comprehensively by enabling a high-resolution genome-wide analysis of genetic aberrations. High resolution analysis can reveal small aberrations not readily seen using traditional techniques.

21 Jan 2014

Synthelis secures initial funding to accelerate commercial development of membrane proteins

Synthelis, a company specializing in the production and characterization of therapeutic targets and antigens, announces today that it has secured initial backing of EUR 610,000 from a group of French investors comprising Rhone-Alpes Creation, Alpes Developpement Durable Investissement (A2D-Invest), Sud Rhone-Alpes Capital, Viaduc and the Savoy and Grenoble Business Angels networks.

21 Jan 2014

Splicing factor SRSF6 promotes hyperplasia of sensitized skin

Normally, tissue injury triggers a mechanism in cells that tries to repair damaged tissue and restore the skin to a normal, or homeostatic state. Errors in this process can give rise to various problems, such as chronic inflammation, which is a known cause of certain cancers.

21 Jan 2014

Scientists discover novel mechanism that influences GAS virulence at early steps of necrotizing fasciitis

How does Streptococcus pyogenes, or Group A streptococcus (GAS) — a bacterial pathogen that can colonize humans without causing symptoms or can lead to mild infections — also cause life-threatening diseases such as necrotizing fasciitis (commonly known as flesh-eating disease) and streptococcal toxic shock syndrome?

21 Jan 2014

Cell News and Research

Advanced melanoma treatments: an interview with Dr. James Larkin, Consultant Medical Oncologist, The Royal Marsden

Scientists identify specific enzyme essential for brain development

CytRx receives FDA approval to continue dosing aldoxorubicin for patients with soft tissue sarcomas

UT Southwestern' faculty receives Stanley J. Korsmeyer Award for contributions to understanding of autophagy

Italian biochemist receives Louis-Jeantet Prize for Medicine for the year 2014

Parkin and PINK1 function in vesicular trafficking pathway regulates mitochon-drial quality control

Researchers suggest new targets may provide druggable alternatives to Ewing's Sarcoma

Scientists showcase HDL nanotherapy that may provide solution to repeat heart attacks

Scientists identify channel that acts as 'brake', limiting spontaneous pain

Magnetoencephalography can be used to control and train specific targeted brain regions

New guidance recommends prevention of healthcare-associated infections transmitted through HCP attire

Mutation in bone cells may cause acute myeloid leukemia: Study

Damon Runyon Cancer Research Foundation awards $2.25M to six innovative young scientists

Fluxion Biosciences announces release of IsoFlux Rare Cell Enrichment Kit

HUB Foundation for Organoid Technology signs licensing agreement with STEMCELL Technologies

First patient dosed in ADXS-HPV Phase 1/2 study for HPV-associated head and neck cancer

Affymetrix gets FDA clearance to market CytoScan Dx Assay

Synthelis secures initial funding to accelerate commercial development of membrane proteins

Splicing factor SRSF6 promotes hyperplasia of sensitized skin

Scientists discover novel mechanism that influences GAS virulence at early steps of necrotizing fasciitis

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