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Researchers managed to replicate human pancreatic beta cells in mouse model

Klaus Kaestner, PhD, professor of Genetics and postdoctoral fellow Dana Avrahami, PhD, from the Perelman School of Medicine, University of Pennsylvania, published a study this week in the Journal of Clinical Investigation, with colleague Benjamin Glaser, MD, from the Hadassah-Hebrew University Medical Center, Jerusalem, and colleagues. In this study, they were able to replicate human pancreatic beta cells - the cells in our body that produce the critical hormone insulin - in a mouse model in which donor cells were transplanted. The newly replicated cells retained features of mature beta cells and showed a physiological response to glucose.

17 Jan 2014

Single stem cell injection after meniscus knee surgery may provide pain relief, aid in meniscus regrowth

A single stem cell injection following meniscus knee surgery may provide pain relief and aid in meniscus regrowth, according to a novel study appearing in the January issue of the Journal of Bone and Joint Surgery (JBJS).

17 Jan 2014

Gene therapies correct three forms of retinal degenerative diseases

Gene therapies developed by University of Pennsylvania School of Veterinary Medicine researchers have worked to correct different forms of blindness. While effective, the downside to these approaches to vision rescue is that each disease requires its own form of gene therapy to correct the particular genetic mutation involved, a time consuming and complex process.

17 Jan 2014

Hope in sight for sufferers of chronic renal disease

Miss M. spends around 15 hours a week in hospital. Her renal functions are limited, and her kidneys are no longer able to filter toxins from her blood. She is a dialysis patient, forced to rely on this artificial blood purification treatment that, although essential, greatly impairs her quality of life. She has to make three trips a week to the dialysis clinic and going away for longer than a few days is almost out of the question. And Miss M. is no exception: In Germany alone, over six million people suffer from some form of chronic renal disease.

17 Jan 2014

Research uncovers new mechanism in brain cells that may help keep deadly neurological diseases in check

New research from David Westaway, PhD, of the University of Alberta and Jiri Safar, MD, Case Western Reserve University School of Medicine has uncovered a quality control mechanism in brain cells that may help keep deadly neurological diseases in check for months or years.

17 Jan 2014

IRCM researchers show importance of DNA architecture in controlling activity of genes

A study conducted by Marie Kmita's team at the IRCM, in collaboration with Jos-e Dostie at McGill University, shows the importance of the chromatin architecture in controlling the activity of genes, especially those required for proper embryonic development.

17 Jan 2014

CSHL professor identifies two proteins that control structure of chandelier cells

Chandelier cells are neurons that use their unique shape to act like master circuit breakers in the brain's cerebral cortex. These cells have dozens, often hundreds, of branching axonal projections - output channels from the cell body of the neuron - that lend the full structure of a chandelier-like appearance.

17 Jan 2014

Professor wins NSF CAREER grant to develop 5-D in vivo image of atherosclerotic plaques

Currently, the medical community has limited ability in clinically assessing blockages called atherosclerotic plaques in the human body. These dangerous blockages that can lead to heart attacks and strokes are not easily diagnosed due to "the lack of noninvasive imaging techniques to accurately model atherosclerotic plaques in vivo," said Guohua Cao, assistant professor of biomedical engineering at Virginia Tech.

17 Jan 2014

Three new spin-offs emerged from Helmholtz Zentrum München

Three new spin-offs emerged from Helmholtz Zentrum München (HMGU) in 2013: SurgVision, Trianta Immunotherapies and Dosimetrics. Thanks to successful innovation management, the Center has transformed excellent research findings into practical applications and given new impulses to the areas of clinical imaging, immunotherapy and radiation dosimetry.

17 Jan 2014

Research opens way to possible new treatments for bacterial infections

How does Streptococcus pyogenes, or Group A streptococcus (GAS) - a bacterial pathogen that can colonize humans without causing symptoms or can lead to mild infections - also cause life-threatening diseases such as necrotizing fasciitis (commonly known as flesh-eating disease) and streptococcal toxic shock syndrome?

17 Jan 2014

Study: Pro-inflammatory molecules linked with early death in HIV patients who abuse alcohol

A study led by researchers at Boston University School of Medicine (BUSM) provides new insight into the impact that pro-inflammatory molecules have on early death in HIV patients who abuse alcohol.

17 Jan 2014

Immune system plays important role in heart's response to injury

The immune system plays an important role in the heart's response to injury. But until recently, confusing data made it difficult to distinguish the immune factors that encourage the heart to heal following a heart attack, for example, from those that lead to further damage.

16 Jan 2014

Study explores the role of DNA in predisposing individuals to diseases

A group of international researchers, led by a research fellow in the Harvard Medical School-affiliated Institute for Aging Research at Hebrew SeniorLife, published a paper today in Cell describing a study aimed at better understanding how inherited genetic differences, or variants, predispose certain individuals to develop diseases such as type 2 diabetes.

16 Jan 2014

New dye more effective in detecting, measuring cardiolipin in cell membranes

A team that includes Dartmouth College researchers has discovered a new way to detect cardiolipin, a key indicator of heart diseases and some genetic disorders.

16 Jan 2014

Research findings may offer new way to treat prion diseases

New research from David Westaway, PhD, of the University of Alberta and Jiri Safar, PhD, Case Western Reserve University School of Medicine has uncovered a quality control mechanism in brain cells that may help keep deadly neurological diseases in check for months or years.

16 Jan 2014

Cedars-Sinai researcher to receive 2014 Troland Research Award

Ueli Rutishauser, PhD, assistant professor of neurosurgery and director of human neurophysiology research in the Department of Neurosurgery and the Department of Neurology at Cedars-Sinai, will receive a 2014 Troland Research Award at the National Academy of Sciences annual meeting April 27.

16 Jan 2014

HDAC2 inhibitor could improve post-traumatic stress disorder treatment: Study

Nearly 8 million Americans suffer from posttraumatic stress disorder, a condition marked by severe anxiety stemming from a traumatic event such as a battle or violent attack.

16 Jan 2014

FDA-regulated study investigates use of child's stem cells for acquired sensorineural hearing loss

Cord Blood Registry, the world's largest and most experienced newborn stem cell company, announces the start of a U.S. Food and Drug-regulated study being conducted at Florida Hospital for Children in Orlando to investigate the use of a child's stem cells from their own stored umbilical cord blood as a treatment for acquired sensorineural hearing loss.

16 Jan 2014

Biothera enhances innate immune responses to Imprime PGG drug candidate

Biothera has enhanced innate immune responses to its cancer immunotherapy drug candidate Imprime PGG in subjects regardless of biomarker status, demonstrating the opportunity to treat a larger patient population. The in vitro research will be presented today at the Cambridge Healthtech Institute's Antibody-Drug Conjugates/Engineering Targeted Therapeutics conference in Palm Springs, CA.

16 Jan 2014

Prostate cancer vaccines receive a boost in funding

The development of two innovative new vaccines that are hoped to offer an alternative to castration therapy for men with recurring prostate cancer, is due for an $8 million boost in funding.

16 Jan 2014

Cell News and Research

Researchers managed to replicate human pancreatic beta cells in mouse model

Single stem cell injection after meniscus knee surgery may provide pain relief, aid in meniscus regrowth

Gene therapies correct three forms of retinal degenerative diseases

Hope in sight for sufferers of chronic renal disease

Research uncovers new mechanism in brain cells that may help keep deadly neurological diseases in check

IRCM researchers show importance of DNA architecture in controlling activity of genes

CSHL professor identifies two proteins that control structure of chandelier cells

Professor wins NSF CAREER grant to develop 5-D in vivo image of atherosclerotic plaques

Three new spin-offs emerged from Helmholtz Zentrum München

Research opens way to possible new treatments for bacterial infections

Study: Pro-inflammatory molecules linked with early death in HIV patients who abuse alcohol

Immune system plays important role in heart's response to injury

Study explores the role of DNA in predisposing individuals to diseases

New dye more effective in detecting, measuring cardiolipin in cell membranes

Research findings may offer new way to treat prion diseases

Cedars-Sinai researcher to receive 2014 Troland Research Award

HDAC2 inhibitor could improve post-traumatic stress disorder treatment: Study

FDA-regulated study investigates use of child's stem cells for acquired sensorineural hearing loss

Biothera enhances innate immune responses to Imprime PGG drug candidate

Prostate cancer vaccines receive a boost in funding

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