Immune Response News and Research

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SARS-CoV-2 viral load in saliva may be linked to COVID-19 disease severity

Researchers at Yale University School of Medicine found that SARS-CoV-2 viral loads in saliva are higher for patients with associated risk factors and underlying conditions that lead to severe COVID-19 and death. Thus, saliva viral loads could be used to predict disease severity.

7 Jan 2021

Severe COVID-19 recovered patients do not display long-lasting adaptive immune responses, finds study

A team of scientists from the University of Valencia and INCLIVA Health Research Institute, Spain, has recently investigated the durability of immune responses specifically developed against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of coronavirus disease 2019 (COVID-19).

7 Jan 2021

MD Anderson and Xencor to develop novel antibody therapeutics to treat cancer patients

The University of Texas MD Anderson Cancer Center and Xencor, Inc. today announced a strategic research collaboration and commercialization agreement to develop novel CD3 bispecific antibody therapeutics for the potential treatment of patients with cancer.

7 Jan 2021

Researchers examine the role of Shiga toxin in the immune system

E. coli food poisoning is one of the worst food poisonings, causing bloody diarrhea and kidney damage. But all the carnage might be just an unintended side effect, researchers from UConn Health report in the 27 November issue of Science Immunology.

7 Jan 2021

Study: Durable immunity against secondary COVID-19 disease is possible in most individuals

Researchers who studied antibody and immune cell responses in more than 180 men and women who had recovered from COVID-19 report these patients' immune memory to the virus - across all immune cell types studied - was measurable for up to 8 months after symptoms appeared.

7 Jan 2021

ACE2 receptor is responsible for the wide host range of SARS-CoV-2

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is thought to have a zoonotic origin, perhaps originating in a bat coronavirus with an unknown intermediate host. It is not only very infectious but has been found to infect a wide range of mammals, including dogs, cats, ferrets, hamsters, and minks, besides non-human primates. This range may be still higher, claims a recent preprint that appeared in January 2021 on the bioRxiv server.

6 Jan 2021

Adaptive immune system against COVID-19 can last for at least eight months

New data suggest that nearly all COVID-19 survivors have the immune cells necessary to fight re-infection.

6 Jan 2021

In-silico modeling provides new understanding of immune response to SARS-CoV-2

The COVID-19 pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has crippled global healthcare systems and triggered an economic crisis in many countries. The pandemic is not showing signs of a slowdown even in 2021 with a new and more infectious variant of the virus wreaking havoc in the UK and many other parts of the world.

6 Jan 2021

Study shows durable specific humoral immunity against SARS-CoV-2 after mild or asymptomatic infection

As a part of the COMMUNITY (COVID-19 Immunity) study, researchers from Sweden reveal long-lasting IgG neutralizing antibody response against spike glycoprotein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the vast majority of convalescent individuals – even after asymptomatic or mild infection. Their results are currently available on medRxiv* preprint server.

6 Jan 2021

Researchers receive £230,000 to develop world's first smart vaccine device

Researchers at Swansea University have received £230,000 to develop the world's first smart vaccine device that will both deliver the COVID-19 vaccine and measure its efficacy through monitoring the body's associated response.

6 Jan 2021

Scientists develop a new method to study the molecular characteristics of T cells

UT Southwestern scientists have developed a new method to study the molecular characteristics of T cells, critical immune cells that recognize and attack invaders in the body such as viruses, bacteria, and cancer.

6 Jan 2021

Vitamin D supplementation found to reduce COVID-19-related mortality, says study

Researchers have shown that prescribing vitamin D supplementation to COVID-19 patients seems to decrease the mortality rate, the severity of the disease, and serum levels of inflammatory markers.

6 Jan 2021

Modified Vaccinia Ankara model vaccine prevents COVID-19 in transgenic mice study

A new study shows the effectiveness of a novel recombinant vaccinia virus that expresses modified SARS-CoV-2 spike antigen, in preventing the replication of the virus in the respiratory tract of transgenic mice, and to prevent lethal disease.

6 Jan 2021

New mathematical model proposes optimal treatment strategies for COVID-19

Getting control of COVID-19 will take more than widespread vaccination; it will also require a better understanding of why the disease causes no apparent symptoms in some people but leads to rapid multi-organ failure and death in others, as well as better insight into what treatments work best and for which patients.

5 Jan 2021

UC-MSC infusions reduce risk of death, quicken recovery time in severe COVID-19 cases

Dr. Camilo Ricordi, director of the Diabetes Research Institute and Cell Transplant Center at the University of Miami Miller School of Medicine, and his team of international collaborators are reporting the results of a groundbreaking randomized controlled trial showing umbilical cord-derived mesenchymal stem cell (UC-MSC) infusions safely reduce risk of death and quicken time to recovery for the most severe COVID-19 patients.

5 Jan 2021

Researchers discover protein crucial to T cell metabolism and anti-tumor immune response

Researchers at The University of Texas MD Anderson Cancer Center have discovered that a protein called NF-kappa B-inducing kinase (NIK) is essential for the shift in metabolic activity that occurs with T cell activation, making it a critical factor in regulating the anti-tumor immune response.

4 Jan 2021

Research offers clues on why pregnancy may raise risk of organ transplant rejection

A research study at the University of Chicago has found that in pregnancy, while the T cell response to a fetus becomes tolerant to allow for successful pregnancy, the part of the immune system that produces antibodies (known as the humoral response) becomes sensitized, creating memory B cells that can later contribute to the rejection of a transplanted organ.

4 Jan 2021

Study uncovers why cancer patients with liver metastases have poor outcomes

Michael Green, M.D., Ph.D., noticed that when his patients had cancer that spread to the liver, they fared poorly – more so than when cancer spread to other parts of the body. Not only that, but transformative immunotherapy treatments had little impact for these patients.

4 Jan 2021

New cell therapy can boost immunotherapy against breast cancer

Boosting immune system T cells to effectively attack solid tumors, such as breast cancers, can be done by adding a small molecule to a treatment procedure called chimeric antigen receptor-T (CAR-T) cell therapy, according to a study by researchers at the UNC Lineberger Comprehensive Cancer Center.

4 Jan 2021

Brain damage is not caused by direct COVID-19 attack, indicates study

n an in-depth study of how COVID-19 affects a patient's brain, National Institutes of Health researchers consistently spotted hallmarks of damage caused by thinning and leaky brain blood vessels in tissue samples from patients who died shortly after contracting the disease.

3 Jan 2021

Immune Response News and Research

SARS-CoV-2 viral load in saliva may be linked to COVID-19 disease severity

Severe COVID-19 recovered patients do not display long-lasting adaptive immune responses, finds study

MD Anderson and Xencor to develop novel antibody therapeutics to treat cancer patients

Researchers examine the role of Shiga toxin in the immune system

Study: Durable immunity against secondary COVID-19 disease is possible in most individuals

ACE2 receptor is responsible for the wide host range of SARS-CoV-2

Adaptive immune system against COVID-19 can last for at least eight months

In-silico modeling provides new understanding of immune response to SARS-CoV-2

Study shows durable specific humoral immunity against SARS-CoV-2 after mild or asymptomatic infection

Researchers receive £230,000 to develop world's first smart vaccine device

Scientists develop a new method to study the molecular characteristics of T cells

Vitamin D supplementation found to reduce COVID-19-related mortality, says study

Modified Vaccinia Ankara model vaccine prevents COVID-19 in transgenic mice study

New mathematical model proposes optimal treatment strategies for COVID-19

UC-MSC infusions reduce risk of death, quicken recovery time in severe COVID-19 cases

Researchers discover protein crucial to T cell metabolism and anti-tumor immune response

Research offers clues on why pregnancy may raise risk of organ transplant rejection

Study uncovers why cancer patients with liver metastases have poor outcomes

New cell therapy can boost immunotherapy against breast cancer

Brain damage is not caused by direct COVID-19 attack, indicates study

Understanding the DNA Damage Response in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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