Cell Migration News and Research

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New cell and animal model of IBC

Inflammatory breast cancer (IBC) is a very aggressive, often misunderstood type of cancer that is diagnosed more frequently in younger women compared with other types of breast cancer. The five-year survival rate is between 25 and 50 percent-significantly lower than the survival rate for other types of breast cancer. The reason for the poor prognosis is that IBC usually grows rapidly and often spreads quickly to other parts of the body, including the brain, bone and lymph nodes.

5 Apr 2012

Pfizer to present data on ADCs at AACR 2012

Pfizer Oncology will present data from a variety of preclinical and clinical studies of Pfizer's early-stage compounds, including data from Pfizer's investigational antibody-drug conjugate (ADC) portfolio and research evaluating several molecules targeting novel pathways that play a crucial role in basic cellular functions, at the American Association for Cancer Research (AACR) Annual Meeting 2012 in Chicago, IL, from March 31-April 4.

27 Mar 2012

Study provides insight into developing new treatment strategies for triple-negative breast cancer

A new study by University of Kentucky researchers provides insight into developing new treatment strategies for basal-like breast cancer, commonly known as triple-negative breast cancer. This cancer is associated with early metastasis and resistance to chemotherapy and occurs at women at a younger age.

15 Mar 2012

RhoGDI2 protein helps prevent bladder cancer metastasis to the lungs

The diagnosis of localized bladder cancer carries an 80 percent five-year survival rate, but once the cancer spreads, the survival rate at even three years is only 20 percent. A major study published today in the Journal of Clinical Investigation not only shows how bladder cancer metastasizes to the lungs but pinpoints a method for stopping this spread.

13 Mar 2012

External cues affect cell's ability to migrate

In a paper published today in the journal, Cell, a team from the University of North Carolina at Chapel Hill has explained for the first time how a long-studied protein complex affects cell migration and how external cues affect cell's ability to migrate.

2 Mar 2012

p14 ARF protein also regulates tumor-induced angiogenesis

Researchers at Winship Cancer Institute of Emory University have identified a new function for a gene that normally prevents the development of cancer.

2 Mar 2012

Combined bioactive peptides successfully stimulate wound healing

Researchers have combined bioactive peptides to successfully stimulate wound healing. The in vitro and in vivo study, published today in PLoS ONE, demonstrates that the combination of two peptides stimulates the growth of blood vessels and promotes re-growth of tissue. Further development of these peptides could lead to a new treatment for chronic and acute wounds.

24 Feb 2012

New 3D computer model to understand cancer development

Observing that certain cancer cells may exhibit greater flexibility than normal cells, some scientists believe that this capability promotes rapid tumor growth. Now computer simulations developed by Boston University Biomedical Engineering Assistant Professor Muhammad Zaman and collaborators at the University of Texas at Austin appear to support this view.

10 Feb 2012

Study shows how to stop brain cancer cell proliferation and migration

Brain cancer is hard to treat: it's not only strong enough to resist most chemotherapies, but also nimble enough to migrate away from radiation or surgery to regrow elsewhere. New research at the University of Colorado Cancer Center shows how to stop both.

18 Jan 2012

Elevated ISG15 pathway may provide therapeutic targets for breast cancer

Interferon-stimulated gene 15 (ISG15), a ubiquitin like protein, is highly elevated in a variety of cancers including breast cancer. How the elevated ISG15 pathway contributes to tumorigenic phenotypes remains unclear and is the subject of a study published in the January 2012 issue of Experimental Biology and Medicine.

12 Jan 2012

PCI-32765 produces durable remissions in Phase I/II CLL clinical trial

A new, targeted approach to treating chronic lymphocytic leukemia has produced durable remissions in a Phase I/II clinical trial for patients with relapsed or resistant disease, investigators report at the 53rd Annual Meeting of the American Society of Hematology.

12 Dec 2011

Researchers uncover binding pocket of 'functional significance' in Ras oncoprotein

A drug discovery team at Genentech, Inc., has uncovered a chink in the molecular armor of Ras, the most commonly occurring oncogene, which is a gene that when mutated has the potential of causing cancer in humans.

5 Dec 2011

World Cell Race pulls 70 entries for title of world's fastest cell

A "team" of fast-moving, bone marrow stem cells from a research laboratory in Singapore has run away with the first World Cell Race, finishing first with a cellular speed record of 5.2 microns per minute (or 0.000204 inches per minute) in results announced today at the 51st Annual Meeting of the American Society for Cell Biology (ASCB).

3 Dec 2011

Specific electromagnetic fields can block cancer cell growth

New evidence by University of Alabama at Birmingham researchers that specific electromagnetic fields can safely block the proliferation of cancer cells and tumor growth may help refine a new, targeted therapy without any collateral damage.

2 Dec 2011

Fascin protein may play a critical transformation role in TGF beta mediated tumor metastasis

A protein called "fascin" appears to play a critical transformation role in TGF beta mediated tumor metastasis, say researchers at Moffitt Cancer Center in Tampa, Fla., who published a study in a recent issue of the Journal of Biological Chemistry.

10 Nov 2011

Einstein scientists receive two NCI grants to study cancer metastasis

The National Cancer Institute (NCI) has awarded Albert Einstein College of Medicine of Yeshiva University two grants totaling $8 million to study the microenvironments that drive the spread of cancer from the primary tumor to other parts of the body in the process known as metastasis.

4 Nov 2011

SCP acts as an important inhibitor of cancer cell migration and growth

A revolutionary discovery regarding motile cancer cells made by research scientists at VTT Technical Research Centre of Finland and the University of Turku is challenging previous conceptions.

22 Oct 2011

Scientists identify stress receptor that stimulates growth and migration of cancer cells

It's a common belief that there's a link between chronic stress and an increased risk of cancer. In new research published online by the International Journal of Cancer, scientists at The University of Western Ontario have taken a step toward confirming that belief.

22 Sep 2011

New imaging device enables scientists to see tumor cells traveling in the brain

For the first time, scientists can see pathways to stop a deadly brain cancer in its tracks. Researchers at Case Western Reserve University School of Medicine have imaged individual cancer cells and the routes they travel as the tumor spreads.

26 Aug 2011

Femtosecond-laser ablation of Xenopus melanocytes for studies of cell migration, wound repair

Using an ultrafast femtosecond laser, researchers at Tufts University in Medford, Mass., were able to label, draw patterns on, and remove individual melanocytes cells from a species of frog tadpole (Xenopus) without damaging surrounding cells and tissues.

19 Aug 2011