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Trial of three vaccines for Zaire Ebola virus disease

Researchers perform two randomized controlled trials to determine immunogenicity and safety of three Ebola vaccines.

20 Dec 2022

Seroprevalence measurements reveal a higher incidence of asymptomatic SARS-CoV-2 infections among residents of three federal German states

Researchers measured the seroprevalence against SARS-CoV-2 in blood donors from the states of Hesse, Lower Saxony, and North Rhine-Westphalia in Germany to determine the incidence of undetected asymptomatic SARS-CoV-2 infections.

20 Dec 2022

Study identifies four new monoclonal antibodies with broad neutralizing potencies that target conserved SARS-CoV-2 epitopes

Researchers described four novel monoclonal antibodies with potent and broad neutralization activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, including the current globally dominant Omicron BA.4/BA.5.

20 Dec 2022

Nasal antibodies decline nine months after COVID-19 infection, study finds

A new study finds that antibodies produced in the nose decline nine months after COVID-19 infection, while antibodies found in the blood last at least a year.

20 Dec 2022

Milk antibodies against SARS-CoV-2 after booster vaccination and breakthrough infection

Researchers longitudinally evaluated the antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in lactating individuals.

19 Dec 2022

Exploring microstructural brain abnormalities after mild COVID-19

Researchers assessed the functional and microstructural brain abnormalities, tiredness, and cognitive impairment after mild coronavirus disease 2019 (COVID-19).

19 Dec 2022

Study demonstrates robust antibody response elicited by trivalent protein subunit vaccine against SARS-CoV-2

Researchers demonstrated that a trivalent vaccine against SARS-CoV-2 improved the breadth of humoral immune responses in mice.

19 Dec 2022

Rise and waning of SARS-CoV-2 antibody responses induced by mRNA vaccine booster in a healthcare worker population

Researchers reported the waning of antibodies against SARS-CoV-2 in the six months following a booster dose of the mRNA COVID-19 vaccine.

19 Dec 2022

Exploring taste and smell dysfunction as strong predictors of SARS-CoV-2 infections

Researchers investigated whether coronavirus disease 2019 (COVID-19)-associated chemosensory alterations were predictive of serological responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among United States (US) residents.

16 Dec 2022

Researchers report the development of robust candidate single immunization PNP hydrogel COVID vaccines

Researchers developed a one-dose subunit vaccine for the induction of durable, potent, and broad immunity against SARS-CoV-2.

16 Dec 2022

Data mining approaches for the detection of signals associated with pediatric post-acute sequelae of COVID-19

Researchers described tree-based scan statistics for pediatric long COVID-19.

16 Dec 2022

Scientists identify a novel epitope at the SARS-CoV-2 spike furin cleavage site

Scientists identify an immunogenic epitope at the furin cleavage site of the SARS-CoV-2 spike protein.

15 Dec 2022

Protein expression signature distinguishes early from late stage diffuse alveolar damage

Researchers identified a protein expression signature that can distinguish early diffuse alveolar damage (DAD) from late DAD in coronavirus disease 2019 (COVID-19) patients.

15 Dec 2022

Polymorphisms in human immunoglobulin heavy chain genes can influence the function of SARS-CoV-2 neutralizing antibodies

Researchers isolated SARS-CoV-2 spike protein-targeted mAbs from convalescent healthcare workers, emphasizing the IGHV1-69 gene, the gene with the greatest structural and allelic variation.

14 Dec 2022

Study indicates need for developing mucosal vaccines to induce potent immune responses at sites where SARS-CoV-2 infection occurs

Researchers measured the antibodies against SARS-CoV-2 from nasal fluid, saliva, and plasma to compare the antibody levels between blood and mucosal fluids.

14 Dec 2022

Characterization of immune evasion and cell entry for new variants: BQ.1.1, XBB.1, and BR.2.1

In a recent study posted to the medRxiv* preprint server, researchers in Australia and Switzerland evaluated the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in community-based settings of the United States (US).

13 Dec 2022

Obesity and type 2 diabetes impair mRNA COVID vaccine efficacy in mouse model

In a recent study posted to bioRxiv*, researchers in the United States assessed the impact of metabolic diseases on coronavirus disease 2019 (COVID-19) vaccine immunogenicity in a mouse model.

13 Dec 2022

Researchers identify molecular determinants of post-infection long-COVID

In a recent study published in the journal Nature Medicine, researchers presented a transcriptome-wide assessment of blood gene expression changes that occur in acute COVID-19 (coronavirus disease 2019) and are associated with PASC (post-acute sequelae of COVID-19), commonly known as long-COVID.

13 Dec 2022

Immunogenicity of SARS-CoV-2 antibody response in immune naïve children and adults

Researchers compare the contribution of antibodies against the SARS-CoV-2 receptor binding domain in vaccinated and naturally infected adults and children.

12 Dec 2022

Study shows potential benefits of efgartigimod as a treatment for immune thrombocytopenia

Patients taking efgartigimod, a drug being studied for use to treat chronic primary immune thrombocytopenia (ITP), exhibited a significantly greater improvement in platelet counts which are essential to clotting and stopping bleeding, compared to those taking a placebo, according to results reported from the ADVANCE IV clinical trial, which was conducted globally, including at Georgetown University Medical Center.

12 Dec 2022

Immunoglobulin News and Research

Trial of three vaccines for Zaire Ebola virus disease

Seroprevalence measurements reveal a higher incidence of asymptomatic SARS-CoV-2 infections among residents of three federal German states

Study identifies four new monoclonal antibodies with broad neutralizing potencies that target conserved SARS-CoV-2 epitopes

Nasal antibodies decline nine months after COVID-19 infection, study finds

Milk antibodies against SARS-CoV-2 after booster vaccination and breakthrough infection

Exploring microstructural brain abnormalities after mild COVID-19

Study demonstrates robust antibody response elicited by trivalent protein subunit vaccine against SARS-CoV-2

Rise and waning of SARS-CoV-2 antibody responses induced by mRNA vaccine booster in a healthcare worker population

Exploring taste and smell dysfunction as strong predictors of SARS-CoV-2 infections

Researchers report the development of robust candidate single immunization PNP hydrogel COVID vaccines

Data mining approaches for the detection of signals associated with pediatric post-acute sequelae of COVID-19

Scientists identify a novel epitope at the SARS-CoV-2 spike furin cleavage site

Protein expression signature distinguishes early from late stage diffuse alveolar damage

Polymorphisms in human immunoglobulin heavy chain genes can influence the function of SARS-CoV-2 neutralizing antibodies

Study indicates need for developing mucosal vaccines to induce potent immune responses at sites where SARS-CoV-2 infection occurs

Characterization of immune evasion and cell entry for new variants: BQ.1.1, XBB.1, and BR.2.1

Obesity and type 2 diabetes impair mRNA COVID vaccine efficacy in mouse model

Researchers identify molecular determinants of post-infection long-COVID

Immunogenicity of SARS-CoV-2 antibody response in immune naïve children and adults

Study shows potential benefits of efgartigimod as a treatment for immune thrombocytopenia

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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