Antifungal News and Research

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The genetics of Candida albicans to be explored

A University of Arkansas postdoctoral researcher has received funding from the American Heart Association to study the genetics of a fungus that has the potential to kill people when they are most vulnerable - after organ transplants.

1 Nov 2007

Discovery of cause of Job's syndrome

The rare immunodeficiency disorder known as Job's syndrome is caused by a specific genetic mutation that both overstimulates and understimulates the human immune system, leading to harmful bacterial and fungal infections and the physical features characteristic of the syndrome, according to two independent groups of scientists, one from the National Institutes of Health (NIH) and the other from the Tokyo Medical and Dental University.

20 Sep 2007

Most chronic sinusitis cases are from fungal-induced inflamma

Accentia Biopharmaceuticals announces evidence that most, if not all cases of chronic sinusitis (CS), are due to a fungal-induced inflammation as originally proposed by investigators at the Mayo Clinic.

11 Sep 2007

White blood cells are picky about sugar

Biology textbooks are blunt - neutrophils are mindless killers. These white blood cells patrol the body and guard against infection by bacteria and fungi, identifying and destroying any invaders that cross their path. But new evidence, which may lead to better drugs to fight deadly pathogens, indicates that neutrophils might actually distinguish among their targets.

11 Jul 2007

Congress urged to cover home infusion therapy for Medicare beneficiaries

The Infectious Diseases Society of America (IDSA) is urging Congress to support the Medicare Home Infusion Therapy Coverage Act of 2007 (H.R. 2567), bipartisan legislation introduced yesterday by Reps.

8 Jun 2007

Drug for toenail fungus also blocks angiogenesis

Researchers at Johns Hopkins have discovered to their surprise that a drug commonly used to treat toenail fungus can also block angiogenesis, the growth of new blood vessels commonly seen in cancers.

30 Apr 2007

Antifungal drug kills tuberculosis bug

Scientists hoping to find new treatments for one of the world's most deadly infectious diseases say drugs used to treat common fungal infections may provide the answer.

From The University of Manchester 12 Mar 2007

New drug delivery method incorporates drug molecules in fat

Devastating blood-borne fungal infections that can be lethal for HIV/AIDS, cancer, and organ transplant patients may be treated more successfully, thanks to a new drug delivery method developed by researchers at the University of British Columbia in Vancouver.

5 Mar 2007

Determinants of disease presentation and outcome during cryptococcosis

CRNS and the Institut Pasteur conducted research in France on patients diagnosed with cryptococcosis which ranks second among fatal opportunistic infections in patients infected by HIV and who are profoundly immunosuppressed.

12 Feb 2007

FDA approves Noxafil (posaconazole) to prevent invasive fungal infections

The U.S. Food and Drug Administration has approved Noxafil (posaconazole) to prevent fungal infections caused by certain molds and yeast-like fungus called Aspergillus and Candida.

19 Sep 2006

Genetic key to treating deadly fungal infections

University of Minnesota researchers have discovered how a prevalent fungal pathogen that causes 10,000 deaths per year in the United States overcomes the effects of antifungal drugs by duplicating a section of one of its chromosomes.

24 Jul 2006

Scientists learn valuable lesson from nature - secret behind nature's medicines

After years of wondering how organisms managed to create self-medications, such as anti-fungal agents, chemists have discovered the simple secret.

3 May 2006

Pfizer receives FDA approval for Eraxis to treat candidemia

Pfizer said today that Eraxis (anidulafungin) has been approved by the U.S. Food and Drug Administration to treat candidemia, a potentially life-threatening bloodstream infection. Candidemia is the most deadly of the common hospital-acquired bloodstream infections, with a mortality rate of approximately 40 percent.

21 Feb 2006

New method to find new metabolites

Ever since penicillin, a byproduct of a fungal mold, was discovered in 1929, scientists have scrutinized fungi for other breakthrough drugs. As reported Jan. 20 in the Journal of Chemistry and Biology, a team led by a University of Wisconsin-Madison researcher has developed a new method that may speed the ongoing quest for medically useful compounds in fungi.

23 Jan 2006

Study proves the effectiveness of Vfend for the treatment of candidemia

Using Vfend (voriconazole) for the treatment of nonneutropenic patients with candidemia, an often-fatal hospital-acquired bloodstream infection, is as effective as a regimen of two older antifungals and carries fewer serious side effects than that regimen.

7 Nov 2005

Study suggests that sinusitis is more common than previously thought in people with chronic cough

In a new Mayo Clinic study, researchers found that more than one-third of chronic cough patients given a CT scan had sinusitis, inflammation of the sinuses. Findings will be presented at the American College of Chest Physicians CHEST 2005 meeting in Montreal.

3 Nov 2005

Wound dressing to stop antibiotic-resistant bacteria from spreading

University of Florida researchers have led the development of a new type of wound dressing that could keep dangerous antibiotic-resistant bacteria from spreading in hospitals, a problem that leads to thousands of deaths in the United States each year.

27 Sep 2005

Carbon nanotubes as transport agents for antimycotics (antifungal agents)

Putting pharmaceutical agents into the body isn't hard, but getting them into targeted areas can be problematic. If drugs aren't taken up by a large enough proportion of cells, a suitable "transport agent" must be used.

19 Sep 2005

Old skin fungus drug has been found to be a possible cancer treatment

A drug that has been used for 40 years for the treatment of skin fungus has been found to be a possible cancer treatment, according to an international team of scientists. Leslie Wilson, professor of biochemistry and pharmacology at the University of California, Santa Barbara, said that the antifungal drug, griseofulvin, has been shown to inhibit the growth of cancer cells in his laboratory.

30 Jun 2005