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Study generates a picture of the myocardial transcriptional landscape of COVID-19

Researchers profiled cardiac tissue transcriptomes of COVID-19 patients.

5 Apr 2022

Key protein could be a novel target for treatment of patients with B cell signaling deficiencies

The rules to the kids' game "red light, green light" are easy to follow: red always means stop, and green always means go. But now, researchers from Japan have found that a key protein involved in B cell signaling acts as both a red light to signaling in healthy cells and a green light to signaling in immune-deficient cells.

4 Apr 2022

Natural compound found in cardamom shows promise for treating triple-negative breast cancer

Cardamonin - a natural compound found in the spice cardamom and other plants - could have therapeutic potential for triple-negative breast cancer, according to a new study using human cancer cells.

3 Apr 2022

An in-depth analysis of pathogenesis of SARS-CoV-2 and therapeutic options for COVID-19

Scientists discuss the pathogenic characteristics of SARS-CoV-2 and available therapeutic interventions for treating COVID-19.

3 Apr 2022

Role of SARS-CoV-2 S1 subunit in severe COVID-19

A new study aimed to determine whether portions of the SARS-CoV-2 spike protein are capable of activating innate immune cells like Gal-3.

30 Mar 2022

Study shows potential inhibition of SARS-CoV-2 main protease by natural phytochemicals

A new study assessed the molecular dynamics of potentially active natural phytochemicals to target the SARS-CoV-2 main protease.

29 Mar 2022

Examining differences in neurological manifestations induced by SARS-CoV-2 variants in hamsters

Researchers evaluated the neurological complications due to SARS-CoV-2 D614G strain, and variants of concern, Delta and Omicron in a hamster model.

28 Mar 2022

Study explores macrophage susceptibility to SARS-CoV-2 virions

A new study investigated the susceptibility of macrophages to SARS-CoV-2 virions.

25 Mar 2022

Non-hormonal male contraceptive effectively prevents pregnancy in mice

Women have many choices for birth control, ranging from pills to patches to intrauterine devices, and partly as a result, they bear most of the burden of preventing pregnancy.

24 Mar 2022

Study reveals new opportunities for using small molecule drugs to target KRAS mutants

Research published today in Nature Chemical Biology reveals new opportunities for using small molecule drugs to target KRAS, the most commonly mutated protein in cancer.

23 Mar 2022

CD63-expressing extracellular vesicles neutralize SARS-CoV-2 variants of concern

Researchers evaluate antiviral effects of CD63 tetraspanin extracellular vesicles against SARS-CoV-2 and HIV-1.

22 Mar 2022

The effect of SARS-CoV-2 on the expression of CD48 in the lungs and in the peripheral blood of COVID-19 patients

Researchers performed an in situ analysis to evaluate the correlation between CD48 expression and COVID-19.

22 Mar 2022

Angiotensin-converting enzyme 2 allosteric binders found to be effective against SARS-CoV-2

Researchers reported a hybrid approach comprising computational models and high throughput screening to discover allosteric ACE2 binders inhibiting viral replication without interrupting ACE2 renal, pulmonary, immune, and cardiovascular functions.

22 Mar 2022

Glycogen synthase kinase-3 inhibitors found to attenuate COVID-19-associated cytokine storm

In a new study, researchers investigated whether the SARS-CoV-2 spike protein and its S2 subunit induced the expression of C–X–C motif chemokine 10, a subset of cytokine.

21 Mar 2022

Biomarkers to identify SARS-CoV-2 patients requiring invasive mechanical ventilation

Researchers evaluated biomarkers that could help identify COVID-19 patients needing invasive mechanical ventilation.

17 Mar 2022

Yale researchers uncover how to control the blood-brain barrier with a molecule

The brain is composed of billions of neurons - vulnerable cells that require a protective environment to function properly.

16 Mar 2022

In silico identification of novel curcumin derivatives as potential inhibitors against SARS-CoV-2 enzymes

Researchers identified curcumin derivatives as potential inhibitors of SARS-CoV-2 enzymes.

16 Mar 2022

New insight into SARS-CoV-2 nsp14 protein opens door to new drugs

In a recent research paper currently available on bioRxiv* preprint server, scientists from the University of Oxford in the United Kingdom and the University of Auckland in New Zealand identified several structural specificities of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that may serve as viable starting points for the development and optimization of viral inhibitors against coronavirus disease 2019 (COVID-19) and other future threats.

16 Mar 2022

Acacetin shows potency against SARS-CoV-2 spike protein

Researchers use molecular docking to screen phytocompounds and evaluate their binding affinity with SARS-CoV-2.

15 Mar 2022

Sustainable material-based biosensors for SARS-CoV-2 detection

Researchers conducted a brief review on biosensors based on sustainable materials for SARS-CoV-2 detection.

15 Mar 2022

Ligand News and Research

Study generates a picture of the myocardial transcriptional landscape of COVID-19

Key protein could be a novel target for treatment of patients with B cell signaling deficiencies

Natural compound found in cardamom shows promise for treating triple-negative breast cancer

An in-depth analysis of pathogenesis of SARS-CoV-2 and therapeutic options for COVID-19

Role of SARS-CoV-2 S1 subunit in severe COVID-19

Study shows potential inhibition of SARS-CoV-2 main protease by natural phytochemicals

Examining differences in neurological manifestations induced by SARS-CoV-2 variants in hamsters

Study explores macrophage susceptibility to SARS-CoV-2 virions

Non-hormonal male contraceptive effectively prevents pregnancy in mice

Study reveals new opportunities for using small molecule drugs to target KRAS mutants

CD63-expressing extracellular vesicles neutralize SARS-CoV-2 variants of concern

The effect of SARS-CoV-2 on the expression of CD48 in the lungs and in the peripheral blood of COVID-19 patients

Angiotensin-converting enzyme 2 allosteric binders found to be effective against SARS-CoV-2

Glycogen synthase kinase-3 inhibitors found to attenuate COVID-19-associated cytokine storm

Biomarkers to identify SARS-CoV-2 patients requiring invasive mechanical ventilation

Yale researchers uncover how to control the blood-brain barrier with a molecule

In silico identification of novel curcumin derivatives as potential inhibitors against SARS-CoV-2 enzymes

New insight into SARS-CoV-2 nsp14 protein opens door to new drugs

Acacetin shows potency against SARS-CoV-2 spike protein

Sustainable material-based biosensors for SARS-CoV-2 detection

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