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Study on molnupiravir precursor NHC antiviral activity against SARS-CoV-2 variants of concern

In a new study, published on the bioRxiv* preprint server, scientists aimed to determine the reaction of the molnupiravir parent drug (NHC) to different SARS-CoV-2 Variants of Concern (VoCs). They also sought to establish the therapeutic window in a human lung cell model.

29 Nov 2021

Research provides key insights into how the brain processes borders

In the classic "Rubin's vase" optical illusion, you can see either an elaborate, curvy vase or two faces, noses nearly touching. At any given moment, which scene you perceive depends on whether your brain is viewing the central vase shape to be the foreground or background of the picture.

29 Nov 2021

Smart sutureless dressing binds the wound together and wards off infection

It is a staple of science fiction to mock sutures as outdated. The technique has, after all, been in use for at least 5,000 years. Surely medicine should have advanced since ancient Egypt.

29 Nov 2021

Many long-haul COVID-19 patients may experience breathing issues, chronic fatigue syndrome

Many long-haul COVID-19 patients have chronic fatigue syndrome and other breathing issues months after their initial COVID-19 diagnosis, according to study in JACC: Heart Failure, which is the first of its kind to identify a correlation between long-haul COVID-19 and chronic fatigue syndrome.

29 Nov 2021

New phenotype of LRP6 mutation reported for the first time in patients with tooth agenesis

A group led by Prof. Han Dong of Peking University School of Stomatology reported for the first time hand preaxial polydactyly in patients with tooth agenesis carrying a previously unknown mutation of low-density lipoprotein receptor-related protein 6 (LRP6).

29 Nov 2021

$Phase I trial evaluates safety, efficacy of astatine for use in alpha therapy for refractory thyroid cancer patients$

Phase I trial evaluates safety, efficacy of astatine for use in alpha therapy for refractory thyroid cancer patients

A research team from the Graduate School of Medicine at Osaka University has started an investigator-initiated clinical trial of sodium astatine ([211At]NaAt) injection for refractory differentiated thyroid cancer patients.

29 Nov 2021

Cytomegalovirus herpesvirus can accelerate the decline of the immune system, study finds

A research team at the University of Córdoba is studying the alterations that occur in the immune system's T lymphocytes with respect to age and in relation to the cytomegalovirus herpesvirus.

29 Nov 2021

Error rate of bacterial DNA polymerase is consistently higher under microgravity, study shows

On 22 May 2019, scientists from Queen's University boarded a modified Falcon 20 aircraft at Ottawa airport. Scheduled was a 'vomit comet' flight, where the plane repeatedly climbs to 8km in a steep parabola, alternating with a descent in freefall.

29 Nov 2021

The mode of action of essential proteins involved in cancer and Alzheimer´s deciphered

The proteins that belong to the HAT family are essential for life as they transport amino acids across the cell membrane. Although the members of this family are practically identical, some transport certain amino acids and not others.

29 Nov 2021

Rare variants in high-risk autism gene can alter architecture and organization of neurons, study finds

Scientists at the University of North Carolina at Chapel Hill School of Medicine and colleagues have demonstrated that rare variants in the ANK2 gene, consistently found in individuals with autism spectrum disorder (ASD), can alter architecture and organization of neurons, potentially contributing to autism and neurodevelopmental comorbidities.

29 Nov 2021

Researchers develop novel system for rapid and non-invasive detection of skin cholesterol

Cardiovascular diseases (CVDs) are the leading cause of death globally. Monitoring of lipid in patients with coronary heart disease (CHD) is important for decreasing the incidence of cardiovascular events.

29 Nov 2021

Clinical drug research for the treatment of CNS and neurological disorders

Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders.

29 Nov 2021

Saliva samples are effective and much friendlier way to measure SARS-CoV-2-specific antibodies

Saliva samples are easy to obtain and useful for measuring antibodies to SARS-CoV-2 in children, which could facilitate epidemiological surveillance in school settings.

29 Nov 2021

Childhood cancer diagnosis not delayed in Canada during the pandemic, study says

During the first 9 months of the COVID-19 pandemic, researchers did not find a significant difference in the number of new cancer diagnoses in Canadian children compared with before the pandemic, according to a study published in CMAJ.

29 Nov 2021

New discovery about tendon and bone attachment reveals strategies for attaching dissimilar materials

Engineers often use nature to inspire new materials and designs. A discovery by a multi-institutional team of researchers and engineers about how tendon and bone attach in the shoulder joint has uncovered previously unsuspected engineering strategies for attaching dissimilar materials.

29 Nov 2021

Researchers outline how advances in neuroscience demand high-performance computing technology

In the latest issue of Science, Katrin Amunts and Thomas Lippert explain how advances in neuroscience demand high-performance computing technology and will ultimately need exascale computing power.

29 Nov 2021

Biologists discover how a protein in our body works

It's an old needlework trick, and a protein in our body knows it: Instead of threading yarn into the eye from the end, it can be easier to pass a loop through it.

29 Nov 2021

SPORE-funded Kidney Cancer Program at UT Southwestern reports wide array of tumor models to date

Funded by a Specialized Program of Research Excellence award from the National Cancer Institute (NCI), the Kidney Cancer Program at UT Southwestern's Harold C. Simmons Comprehensive Cancer Center reports the largest and most diverse catalog of kidney cancer tumor models to date.

29 Nov 2021

European study endorses dashboards for public reporting during the COVID-19 pandemic

Researchers explore the development of COVID-19 dashboards during the first year of the pandemic.

29 Nov 2021

Simple change can maximize a single cell's production of extracellular vesicles

A simple change in the way donor cells are processed can maximize a single cell's production of extracellular vesicles, which are small nanoparticles naturally secreted by cells, according to new research from researchers at the University of Illinois Chicago.

29 Nov 2021

Research News and Research

Study on molnupiravir precursor NHC antiviral activity against SARS-CoV-2 variants of concern

Research provides key insights into how the brain processes borders

Smart sutureless dressing binds the wound together and wards off infection

Many long-haul COVID-19 patients may experience breathing issues, chronic fatigue syndrome

New phenotype of LRP6 mutation reported for the first time in patients with tooth agenesis

Phase I trial evaluates safety, efficacy of astatine for use in alpha therapy for refractory thyroid cancer patients

Cytomegalovirus herpesvirus can accelerate the decline of the immune system, study finds

Error rate of bacterial DNA polymerase is consistently higher under microgravity, study shows

The mode of action of essential proteins involved in cancer and Alzheimer´s deciphered

Rare variants in high-risk autism gene can alter architecture and organization of neurons, study finds

Researchers develop novel system for rapid and non-invasive detection of skin cholesterol

Clinical drug research for the treatment of CNS and neurological disorders

Saliva samples are effective and much friendlier way to measure SARS-CoV-2-specific antibodies

Childhood cancer diagnosis not delayed in Canada during the pandemic, study says

New discovery about tendon and bone attachment reveals strategies for attaching dissimilar materials

Researchers outline how advances in neuroscience demand high-performance computing technology

Biologists discover how a protein in our body works

SPORE-funded Kidney Cancer Program at UT Southwestern reports wide array of tumor models to date

European study endorses dashboards for public reporting during the COVID-19 pandemic

Simple change can maximize a single cell's production of extracellular vesicles

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