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TSRI scientists to study structural rules that govern nuclear receptors

A consortium of scientists from both campuses of The Scripps Research Institute (TSRI) has been awarded $2.7 million from the National Institute of General Medical Sciences of the National Institutes of Health to study the structural rules that govern a large superfamily of proteins that help regulate critical functions such as reproduction, development and metabolism.

24 Oct 2012

Kessler Foundation to study role of environmental factors in rehabilitation outcomes in SCI

Amanda Botticello, PhD, MPH, research scientist in Outcomes & Assessment Research at Kessler Foundation, received a National Institutes of Health (NIH) grant to study the role of environmental factors in rehabilitation outcomes in spinal cord injury.

24 Oct 2012

World-renowned cardiac researchers to speak at SDSU-hosted symposium

Prominent cardiac researchers will meet at San Diego State University in November to explore bold new approaches to treating the number one threat to U.S. adults - heart disease.

24 Oct 2012

Vascular cell generation could be used to treat vascular disorders

A study in mice has shown that large numbers of vascular endothelial cells can be generated from human amniotic fluid-derived cells.

23 Oct 2012

Researchers increase potency of a compound that reactivates antibiotics against MRSA

Researchers from North Carolina State University have increased the potency of a compound that reactivates antibiotics against methicillin-resistant Staphylococcus aureus (MRSA), an antibiotic-resistant form of Staphylococcus that is notoriously difficult to treat. Their improved compound removes the bacteria's antibiotic resistance and allows the antibiotic to once again become effective at normal dosage levels.

23 Oct 2012

KIF3A protein ferries HIV to the plasma membrane

A study in The Journal of Cell Biology identifies a motor protein that ferries HIV to the plasma membrane, helping the virus escape from macrophages.

23 Oct 2012

Genzyme, Alnylam partner to develop and commercialize RNAi therapeutics against ATTR

Alnylam Pharmaceuticals, Inc. and Genzyme, a Sanofi company, announced today that they have formed an exclusive alliance to develop and commercialize RNAi therapeutics targeting transthyretin (TTR) for the treatment of transthyretin-mediated amyloidosis (ATTR) in Japan and other Asia-Pacific countries.

23 Oct 2012

Most pediatric hospital physicians communicate through cell phone text messaging

More pediatric hospital physicians are communicating through cell phone text messaging, rather than the traditional pager method, according to research presented Oct. 21 at the American Academy of Pediatrics (AAP) National Conference and Exhibition in New Orleans.

23 Oct 2012

Abbott announces results from HUMIRA clinical studies on ulcerative colitis

Abbott (NYSE: ABT) today announced results from an analysis of three-year long-term data from an ongoing open-label extension of the HUMIRA (adalimumab) ULTRA 1 and ULTRA 2 studies.

23 Oct 2012

Study looks at DNA sequences for receptors in T lymphocytes

Our immune system must be tremendously complex to respond to the unending assault of viruses, bacteria and cancerous cells. One of the mechanisms used by the immune system to cope with the huge variety of possible threats is to randomly combine DNA segments for the production of receptors on lymphocytes - a type of white blood cell.

23 Oct 2012

Blood-circulating monocytes can replace brain resident microglia

The immune system is comprised of multiple cell types each capable of specialized functions to protect the body from invading pathogens and promote tissue repair after injury. One cell type, known as monocytes, circulates throughout the organism in the blood and enters tissues to actively phagocytose (eat!) foreign cells and assist in tissue healing.

23 Oct 2012

Bodyguard macrophages protect stem cells from over-differentiation

Hiding deep inside the bone marrow are special cells. They wait patiently for the hour of need, at which point these blood forming stem cells can proliferate and differentiate into billions of mature blood immune cells to help the body cope with infection, for example, or extra red blood cells for low oxygen levels at high altitudes. Even in emergencies, however, the body keeps to a long-term plan: It maintains a reserve of undifferentiated stem cells for future needs and crises.

23 Oct 2012

Advances in endoscopic technologies and techniques to be highlighted at ACG annual meeting

Advances in endoscopic technologies and techniques will be highlighted in clinical research presented at the 77th Annual Scientific Meeting of the American College of Gastroenterology in Las Vegas, NV.

23 Oct 2012

Protective association between statin use and esophageal cancer

Statins, a cholesterol lowering drug may lower the risk of esophageal cancer, especially in patients with Barrett's esophagus, Mayo Clinic researchers report in a study being presented at the American College of Gastroenterology annual meeting.

23 Oct 2012

Sickle cell disease treatments: An interview with Dr Niihara, CEO of Emmaus Medical

Sickle cell disease is a devastating hereditary condition that affects millions of people, particularly those in West and Central Africa as well as people of African descent in the United States, Europe and South America.

23 Oct 2012

Breast cancer spread dependent on both environment and genetic changes

A new study from Johns Hopkins researchers suggests that the lethal spread of breast cancer is as dependent on a tumor’s protein-rich environment as on genetic changes inside tumor cells.

23 Oct 2012

Exercise may protect the brain from age-related changes

People who exercise later in life may better protect their brain from age-related changes than those who do not, a study suggests.

23 Oct 2012

Glioblastoma multiforme can originate from cortical neurons

Scientists have long believed that glioblastoma multiforme (GBM), the most aggressive type of primary brain tumor, begins in glial cells that make up supportive tissue in the brain or in neural stem cells. In a paper published October 18 in Science Express, however, researchers at the Salk Institute for Biological Studies have found that the tumors can originate from other types of differentiated cells in the nervous system, including cortical neurons.

23 Oct 2012

CSF biomarkers can differentiate patients with Alzheimer's or Parkinson disease

Analysis of specific biomarkers in a cerebrospinal fluid sample can differentiate patients with Alzheimer's disease from those with other types of dementia. The method, which is being studied by researchers at Sahlgrenska Academy, may eventually permit earlier detection of Alzheimer's disease.

23 Oct 2012

Methylation provides clues to gastric cancer subtypes

Research published in Science Translational Medicine shows that many gastric cancers are associated with significant epigenetic alterations along the DNA triggered by methylation.

22 Oct 2012